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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
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Ecological insights from three decades of animal movement tracking across a changing Arctic 期刊论文
Science, 2020
作者:  Sarah C. Davidson;  Gil Bohrer;  Eliezer Gurarie;  Scott LaPoint;  Peter J. Mahoney;  Natalie T. Boelman;  Jan U. H. Eitel;  Laura R. Prugh;  Lee A. Vierling;  Jyoti Jennewein;  Emma Grier;  Ophélie Couriot;  Allicia P. Kelly;  Arjan J. H. Meddens;  Ruth Y. Oliver;  Roland Kays;  Martin Wikelski;  Tomas Aarvak;  Joshua T. Ackerman;  José A. Alves;  Erin Bayne;  Bryan Bedrosian;  Jerrold L. Belant;  Andrew M. Berdahl;  Alicia M. Berlin;  Dominique Berteaux;  Joël Bêty;  Dmitrijs Boiko;  Travis L. Booms;  Bridget L. Borg;  Stan Boutin;  W. Sean Boyd;  Kane Brides;  Stephen Brown;  Victor N. Bulyuk;  Kurt K. Burnham;  David Cabot;  Michael Casazza;  Katherine Christie;  Erica H. Craig;  Shanti E. Davis;  Tracy Davison;  Dominic Demma;  Christopher R. DeSorbo;  Andrew Dixon;  Robert Domenech;  Götz Eichhorn;  Kyle Elliott;  Joseph R. Evenson;  Klaus-Michael Exo;  Steven H. Ferguson;  Wolfgang Fiedler;  Aaron Fisk;  Jérôme Fort;  Alastair Franke;  Mark R. Fuller;  Stefan Garthe;  Gilles Gauthier;  Grant Gilchrist;  Petr Glazov;  Carrie E. Gray;  David Grémillet;  Larry Griffin;  Michael T. Hallworth;  Autumn-Lynn Harrison;  Holly L. Hennin;  J. Mark Hipfner;  James Hodson;  James A. Johnson;  Kyle Joly;  Kimberly Jones;  Todd E. Katzner;  Jeff W. Kidd;  Elly C. Knight;  Michael N. Kochert;  Andrea Kölzsch;  Helmut Kruckenberg;  Benjamin J. Lagassé;  Sandra Lai;  Jean-François Lamarre;  Richard B. Lanctot;  Nicholas C. Larter;  A. David M. Latham;  Christopher J. Latty;  James P. Lawler;  Don-Jean Léandri-Breton;  Hansoo Lee;  Stephen B. Lewis;  Oliver P. Love;  Jesper Madsen;  Mark Maftei;  Mark L. Mallory;  Buck Mangipane;  Mikhail Y. Markovets;  Peter P. Marra;  Rebecca McGuire;  Carol L. McIntyre;  Emily A. McKinnon;  Tricia A. Miller;  Sander Moonen;  Tong Mu;  Gerhard J. D. M. Müskens;  Janet Ng;  Kerry L. Nicholson;  Ingar Jostein Øien;  Cory Overton;  Patricia A. Owen;  Allison Patterson;  Aevar Petersen;  Ivan Pokrovsky;  Luke L. Powell;  Rui Prieto;  Petra Quillfeldt;  Jennie Rausch;  Kelsey Russell;  Sarah T. Saalfeld;  Hans Schekkerman;  Joel A. Schmutz;  Philipp Schwemmer;  Dale R. Seip;  Adam Shreading;  Mónica A. Silva;  Brian W. Smith;  Fletcher Smith;  Jeff P. Smith;  Katherine R. S. Snell;  Aleksandr Sokolov;  Vasiliy Sokolov;  Diana V Solovyeva;  Mathew S. Sorum;  Grigori Tertitski;  J. F. Therrien;  Kasper Thorup;  T. Lee Tibbitts;  Ingrid Tulp;  Brian D. Uher-Koch;  Rob S. A. van Bemmelen;  Steven Van Wilgenburg;  Andrew L. Von Duyke;  Jesse L. Watson;  Bryan D. Watts;  Judy A. Williams;  Matthew T. Wilson;  James R. Wright;  Michael A. Yates;  David J. Yurkowski;  Ramūnas Žydelis;  Mark Hebblewhite
收藏  |  浏览/下载:19/0  |  提交时间:2020/11/09
The impact of sex on gene expression across human tissues 期刊论文
Science, 2020
作者:  Meritxell Oliva;  Manuel Muñoz-Aguirre;  Sarah Kim-Hellmuth;  Valentin Wucher;  Ariel D. H. Gewirtz;  Daniel J. Cotter;  Princy Parsana;  Silva Kasela;  Brunilda Balliu;  Ana Viñuela;  Stephane E. Castel;  Pejman Mohammadi;  François Aguet;  Yuxin Zou;  Ekaterina A. Khramtsova;  Andrew D. Skol;  Diego Garrido-Martín;  Ferran Reverter;  Andrew Brown;  Patrick Evans;  Eric R. Gamazon;  Anthony Payne;  Rodrigo Bonazzola;  Alvaro N. Barbeira;  Andrew R. Hamel;  Angel Martinez-Perez;  José Manuel Soria;  GTEx Consortium§;  Brandon L. Pierce;  Matthew Stephens;  Eleazar Eskin;  Emmanouil T. Dermitzakis;  Ayellet V. Segrè;  Hae Kyung Im;  Barbara E. Engelhardt;  Kristin G. Ardlie;  Stephen B. Montgomery;  Alexis J. Battle;  Tuuli Lappalainen;  Roderic Guigó;  Barbara E. Stranger
收藏  |  浏览/下载:14/0  |  提交时间:2020/09/14
SARS-CoV-2 infection protects against rechallenge in rhesus macaques 期刊论文
Science, 2020
作者:  Abishek Chandrashekar;  Jinyan Liu;  Amanda J. Martinot;  Katherine McMahan;  Noe B. Mercado;  Lauren Peter;  Lisa H. Tostanoski;  Jingyou Yu;  Zoltan Maliga;  Michael Nekorchuk;  Kathleen Busman-Sahay;  Margaret Terry;  Linda M. Wrijil;  Sarah Ducat;  David R. Martinez;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Laurent Pessaint;  Alex Van Ry;  Jack Greenhouse;  Tammy Taylor;  Kelvin Blade;  Anthony Cook;  Brad Finneyfrock;  Renita Brown;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Peter Abbink;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Nicole Kordana;  Zhenfeng Li;  Michelle A. Lifton;  Shant H. Mahrokhian;  Lori F. Maxfield;  Ramya Nityanandam;  Joseph P. Nkolola;  Aaron G. Schmidt;  Andrew D. Miller;  Ralph S. Baric;  Galit Alter;  Peter K. Sorger;  Jacob D. Estes;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
DNA vaccine protection against SARS-CoV-2 in rhesus macaques 期刊论文
Science, 2020
作者:  Jingyou Yu;  Lisa H. Tostanoski;  Lauren Peter;  Noe B. Mercado;  Katherine McMahan;  Shant H. Mahrokhian;  Joseph P. Nkolola;  Jinyan Liu;  Zhenfeng Li;  Abishek Chandrashekar;  David R. Martinez;  Carolin Loos;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Yuezhou Chen;  Adam Zuiani;  Felipe J. N. Lelis;  Meghan Travers;  Shaghayegh Habibi;  Laurent Pessaint;  Alex Van Ry;  Kelvin Blade;  Renita Brown;  Anthony Cook;  Brad Finneyfrock;  Alan Dodson;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Marinela Kirilova;  Nicole Kordana;  Zijin Lin;  Lori F. Maxfield;  Felix Nampanya;  Ramya Nityanandam;  John D. Ventura;  Huahua Wan;  Yongfei Cai;  Bing Chen;  Aaron G. Schmidt;  Duane R. Wesemann;  Ralph S. Baric;  Galit Alter;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载:18/0  |  提交时间:2020/08/18
Broad neutralization of SARS-related viruses by human monoclonal antibodies 期刊论文
Science, 2020
作者:  Anna Z. Wec;  Daniel Wrapp;  Andrew S. Herbert;  Daniel P. Maurer;  Denise Haslwanter;  Mrunal Sakharkar;  Rohit K. Jangra;  M. Eugenia Dieterle;  Asparouh Lilov;  Deli Huang;  Longping V. Tse;  Nicole V. Johnson;  Ching-Lin Hsieh;  Nianshuang Wang;  Juergen H. Nett;  Elizabeth Champney;  Irina Burnina;  Michael Brown;  Shu Lin;  Melanie Sinclair;  Carl Johnson;  Sarat Pudi;  Robert Bortz;  Ariel S. Wirchnianski;  Ethan Laudermilch;  Catalina Florez;  J. Maximilian Fels;  Cecilia M. O’Brien;  Barney S. Graham;  David Nemazee;  Dennis R. Burton;  Ralph S. Baric;  James E. Voss;  Kartik Chandran;  John M. Dye;  Jason S. McLellan;  Laura M. Walker
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
The nitrogen budget of laboratory-simulated western US wildfires during the FIREX 2016 Fire Lab study 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  James M. Roberts, Chelsea E. Stockwell, Robert J. Yokelson, Joost de Gouw, Yong Liu, Vanessa Selimovic, Abigail R. Koss, Kanako Sekimoto, Matthew M. Coggon, Bin Yuan, Kyle J. Zarzana, Steven S. Brown, Cristina Santin, Stefan H. Doerr, and Carsten Warneke
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/09
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Microbial processing of plant remains is co‐limited by multiple nutrients in global grasslands 期刊论文
Global Change Biology, 2020
作者:  Raú;  l Ochoa‐;  Hueso;  Elizabeth T. Borer;  Eric W. Seabloom;  Sarah E. Hobbie;  Anita C. Risch;  Scott L. Collins;  Juan Alberti;  ;  ctor A. Bahamonde;  Cynthia S. Brown;  Maria C. Caldeira;  Pedro Daleo;  Chris R. Dickman;  Anne Ebeling;  Nico Eisenhauer;  Ellen H. Esch;  Anu Eskelinen;  Victoria Ferná;  ndez;  Sabine Gü;  sewell;  Blanca Gutierrez‐;  Larruga;  Kirsten Hofmockel;  Ramesh Laungani;  Eric Lind;  Andrea Ló;  pez;  Rebecca L. McCulley;  Joslin L. Moore;  Pablo L. Peri;  Sally A. Power;  Jodi N. Price;  Suzanne M. Prober;  Christiane Roscher;  Judith M. Sarneel;  Martin Schü;  tz;  Julia Siebert;  Rachel J. Standish;  Sergio Velasco Ayuso;  Risto Virtanen;  Glenda M. Wardle;  Georg Wiehl;  Laura Yahdjian;  Tara Zamin
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/16
Monumental architecture at Aguada Fenix and the rise of Maya civilization 期刊论文
NATURE, 2020
作者:  Bedding, Timothy R.;  Murphy, Simon J.;  Hey, Daniel R.;  Huber, Daniel;  Li, Tanda;  Smalley, Barry;  Stello, Dennis;  White, Timothy R.;  Ball, Warrick H.;  Chaplin, William J.;  Colman, Isabel L.;  Fuller, Jim;  Gaidos, Eric;  Harbeck, Daniel R.;  Hermes, J. J.;  Holdsworth, Daniel L.;  Li, Gang;  Li, Yaguang;  Mann, Andrew W.;  Reese, Daniel R.;  Sekaran, Sanjay;  Yu, Jie;  Antoci, Victoria;  Bergmann, Christoph;  Brown, Timothy M.;  Howard, Andrew W.;  Ireland, Michael J.;  Isaacson, Howard;  Jenkins, Jon M.;  Kjeldsen, Hans;  McCully, Curtis;  Rabus, Markus;  Rains, Adam D.;  Ricker, George R.;  Tinney, Christopher G.;  Vanderspek, Roland K.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

Archaeologists have traditionally thought that the development of Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclassic period (1000-350 bc  dates are calibrated throughout) along with the use of ceramics and the adoption of sedentism(1). Recent finds of early ceremonial complexes are beginning to challenge this model. Here we describe an airborne lidar survey and excavations of the previously unknown site of Aguada Fenix (Tabasco, Mexico) with an artificial plateau, which measures 1,400 m in length and 10 to 15 m in height and has 9 causeways radiating out from it. We dated this construction to between 1000 and 800 bc using a Bayesian analysis of radiocarbon dates. To our knowledge, this is the oldest monumental construction ever found in the Maya area and the largest in the entire pre-Hispanic history of the region. Although the site exhibits some similarities to the earlier Olmec centre of San Lorenzo, the community of Aguada Fenix probably did not have marked social inequality comparable to that of San Lorenzo. Aguada Fenix and other ceremonial complexes of the same period suggest the importance of communal work in the initial development of Maya civilization.


Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fenix, which dates to around 1000-800 bc and points to the role of communal construction in the development of Maya civilization.