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Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载:19/0  |  提交时间:2020/12/22
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Archaeological assessment reveals Earth's early transformation through land use 期刊论文
SCIENCE, 2019, 365 (6456) : 897-+
作者:  Stephens, Lucas;  Fuller, Dorian;  Boivin, Nicole;  Rick, Torben;  Gauthier, Nicolas;  Kay, Andrea;  Marwick, Ben;  Armstrong, Chelsey Geralda Denise;  Barton, C. Michael;  Denham, Tim;  Douglass, Kristina;  Driver, Jonathan;  Janz, Lisa;  Roberts, Patrick;  Rogers, J. Daniel;  Thakar, Heather;  Altaweel, Mark;  Johnson, Amber L.;  Sampietro Vattuone, Maria Marta;  Aldenderfer, Mark;  Archila, Sonia;  Artioli, Gilberto;  Bale, Martin T.;  Beach, Timothy;  Borrell, Ferran;  Braje, Todd;  Buckland, Philip I.;  Jimenez Cano, Nayeli Guadalupe;  Capriles, Jose M.;  Diez Castillo, Agustin;  Cilingiroglu, Ciler;  Cleary, Michelle Negus;  Conolly, James;  Coutros, Peter R.;  Covey, R. Alan;  Cremaschi, Mauro;  Crowther, Alison;  Der, Lindsay;  di Lernia, Savino;  Doershuk, John F.;  Doolittle, William E.;  Edwards, Kevin J.;  Erlandson, Jon M.;  Evans, Damian;  Fairbairn, Andrew;  Faulkner, Patrick;  Feinman, Gary;  Fernandes, Ricardo;  Fitzpatrick, Scott M.;  Fyfe, Ralph;  Garcea, Elena;  Goldstein, Steve;  Goodman, Reed Charles;  Guedes, Jade Dalpoim;  Herrmann, Jason;  Hiscock, Peter;  Hommel, Peter;  Horsburgh, K. Ann;  Hritz, Carrie;  Ives, John W.;  Junno, Aripekka;  Kahn, Jennifer G.;  Kaufman, Brett;  Kearns, Catherine;  Kidder, Tristram R.;  Lanoe, Francois;  Lawrence, Dan;  Lee, Gyoung-Ah;  Levin, Maureece J.;  Lindskoug, Henrik B.;  Antonio Lopez-Saez, Jose;  Macrae, Scott;  Marchant, Rob;  Marston, John M.;  McClure, Sarah;  Mccoy, Mark D.;  Miller, Alicia Ventresca;  Morrison, Michael;  Matuzeviciute, Giedre Motuzaite;  Mueller, Johannes;  Nayak, Ayushi;  Noerwidi, Sofwan;  Peres, Tanya M.;  Peterson, Christian E.;  Proctor, Lucas;  Randall, Asa R.;  Renette, Steve;  Schug, Gwen Robbins;  Ryzewski, Krysta;  Saini, Rakesh;  Scheinsohn, Vivian;  Schmidt, Peter;  Sebillaud, Pauline;  Seitsonen, Oula;  Simpson, Ian A.;  Soltysiak, Arkadiusz;  Speakman, Robert J.;  Spengler, Robert N.;  Steffen, Martina L.;  Storozum, Michael J.;  Strickland, Keir M.;  Thompson, Jessica;  Thurston, T. L.;  Ulm, Sean;  Ustunkaya, M. Cemre;  Welker, Martin H.;  West, Catherine;  Williams, Patrick Ryan;  Wright, David K.;  Wright, Nathan;  Zahir, Muhammad;  Zerboni, Andrea;  Beaudoin, Ella;  Garcia, Santiago Munevar;  Powell, Jeremy;  Thornton, Alexa;  Kaplan, Jed O.;  Gaillard, Marie-Jose;  Goldewijk, Kees Klein;  Ellis, Erle
收藏  |  浏览/下载:55/0  |  提交时间:2019/11/27
Deep magma ocean formation set the oxidation state of Earth's mantle 期刊论文
SCIENCE, 2019, 365 (6456) : 903-+
作者:  Armstrong, Katherine;  Frost, Daniel J.;  McCammon, Catherine A.;  Rubie, David C.;  Ballaran, Tiziana Boffa
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies 期刊论文
SCIENCE, 2019, 365 (6453) : 599-+
作者:  Boettcher, Steffen;  Miller, Peter G.;  Sharma, Rohan;  McConkey, Marie;  Leventhal, Matthew;  Krivtsov, Andrei V.;  Giacomelli, Andrew O.;  Wong, Waihay;  Kim, Jesi;  Chao, Sherry;  Kurppa, Kari J.;  Yang, Xiaoping;  Milenkowic, Kirsten;  Piccioni, Federica;  Root, David E.;  Ruecker, Frank G.;  Flamand, Yael;  Neuberg, Donna;  Lindsley, R. Coleman;  Janne, Pasi A.;  Hahn, William C.;  Jacks, Tyler;  Doehner, Hartmut;  Armstrong, Scott A.;  Ebert, Benjamin L.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
High-resolution comparative analysis of great ape genomes 期刊论文
SCIENCE, 2018, 360 (6393) : 1085-+
作者:  Kronenberg, Zev N.;  Fiddes, Ian T.;  Gordon, David;  Murali, Shwetha;  Cantsilieris, Stuart;  Meyerson, Olivia S.;  Underwood, Jason G.;  Nelson, Bradley J.;  Chaisson, Mark J. P.;  Dougherty, Max L.;  Munson, Katherine M.;  Hastie, Alex R.;  Diekhans, Mark;  Hormozdiari, Fereydoun;  Lorusso, Nicola;  Hoekzema, Kendra;  Qiu, Ruolan;  Clark, Karen;  Raja, Archana;  Welch, AnneMarie E.;  Sorensen, Melanie;  Baker, Carl;  Fulton, Robert S.;  Armstrong, Joel;  Graves-Lindsay, Tina A.;  Denli, Ahmet M.;  Hoppe, Emma R.;  Hsieh, PingHsun;  Hill, Christopher M.;  Pang, Andy Wing Chun;  Lee, Joyce;  Lam, Ernest T.;  Dutcher, Susan K.;  Gage, Fred H.;  Warren, Wesley C.;  Shendure, Jay;  Haussler, David;  Schneider, Valerie A.;  Cao, Han;  Ventura, Mario;  Wilson, Richard K.;  Paten, Benedict;  Pollen, Alex;  Eichler, Evan E.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade 期刊论文
SCIENCE, 2017, 357 (6349) : 409-413
作者:  Le, Dung T.;  Durham, Jennifer N.;  Smith, Kellie N.;  Wang, Hao;  Bartlett, Bjarne R.;  Aulakh, Laveet K.;  Lu, Steve;  Kemberling, Holly;  Wilt, Cara;  Luber, Brandon S.;  Wong, Fay;  Azad, Nilofer S.;  Rucki, Agnieszka A.;  Laheru, Dan;  Donehower, Ross;  Zaheer, Atif;  Fisher, George A.;  Crocenzi, Todd S.;  Lee, James J.;  Greten, Tim F.;  Duffy, Austin G.;  Ciombor, Kristen K.;  Eyring, Aleksandra D.;  Lam, Bao H.;  Joe, Andrew;  Kang, S. Peter;  Holdhoff, Matthias;  Danilova, Ludmila;  Cope, Leslie;  Meyer, Christian;  Zhou, Shibin;  Goldberg, Richard M.;  Armstrong, Deborah K.;  Bever, Katherine M.;  Fader, Amanda N.;  Taube, Janis;  Housseau, Franck;  Spetzler, David;  Xiao, Nianqing;  Pardoll, Drew M.;  Papadopoulos, Nickolas;  Kinzler, Kenneth W.;  Eshleman, James R.;  Vogelstein, Bert;  Anders, Robert A.;  Diaz, Luis A., Jr.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27