SARS-CoV-2 infection protects against rechallenge in rhesus macaques

doi:10.1126/science.abc4776

GSTDTAP > 气候变化

DOI	10.1126/science.abc4776
	SARS-CoV-2 infection protects against rechallenge in rhesus macaques
	Abishek Chandrashekar; Jinyan Liu; Amanda J. Martinot; Katherine McMahan; Noe B. Mercado; Lauren Peter; Lisa H. Tostanoski; Jingyou Yu; Zoltan Maliga; Michael Nekorchuk; Kathleen Busman-Sahay; Margaret Terry; Linda M. Wrijil; Sarah Ducat; David R. Martinez; Caroline Atyeo; Stephanie Fischinger; John S. Burke; Matthew D. Slein; Laurent Pessaint; Alex Van Ry; Jack Greenhouse; Tammy Taylor; Kelvin Blade; Anthony Cook; Brad Finneyfrock; Renita Brown; Elyse Teow; Jason Velasco; Roland Zahn; Frank Wegmann; Peter Abbink; Esther A. Bondzie; Gabriel Dagotto; Makda S. Gebre; Xuan He; Catherine Jacob-Dolan; Nicole Kordana; Zhenfeng Li; Michelle A. Lifton; Shant H. Mahrokhian; Lori F. Maxfield; Ramya Nityanandam; Joseph P. Nkolola; Aaron G. Schmidt; Andrew D. Miller; Ralph S. Baric; Galit Alter; Peter K. Sorger; Jacob D. Estes; Hanne Andersen; Mark G. Lewis; Dan H. Barouch
	2020-08-14
发表期刊	Science
出版年	2020
英文摘要	One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al. and Deng et al. generated rhesus macaque models of SARS-CoV-2 infection and tested whether natural SARS-CoV-2 infection could result in immunity to viral rechallenge. They found that animals indeed developed immune responses that protected against a second infection. Although there are differences between SARS-CoV-2 infection in macaques and in humans, these findings have key implications for public health and economic initiatives if validated in human studies. Science , this issue p. [812][1], p. [818][2] An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global coronavirus disease 2019 (COVID-19) pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against reexposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. After the initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with after the primary infection. Anamnestic immune responses after rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against reexposure in nonhuman primates. [1]: /lookup/doi/10.1126/science.abc4776 [2]: /lookup/doi/10.1126/science.abc5343
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/288084
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Abishek Chandrashekar,Jinyan Liu,Amanda J. Martinot,et al. SARS-CoV-2 infection protects against rechallenge in rhesus macaques[J]. Science,2020.
APA	Abishek Chandrashekar.,Jinyan Liu.,Amanda J. Martinot.,Katherine McMahan.,Noe B. Mercado.,...&Dan H. Barouch.(2020).SARS-CoV-2 infection protects against rechallenge in rhesus macaques.Science.
MLA	Abishek Chandrashekar,et al."SARS-CoV-2 infection protects against rechallenge in rhesus macaques".Science (2020).