DNA vaccine protection against SARS-CoV-2 in rhesus macaques

doi:10.1126/science.abc6284

GSTDTAP > 气候变化

DOI	10.1126/science.abc6284
	DNA vaccine protection against SARS-CoV-2 in rhesus macaques
	Jingyou Yu; Lisa H. Tostanoski; Lauren Peter; Noe B. Mercado; Katherine McMahan; Shant H. Mahrokhian; Joseph P. Nkolola; Jinyan Liu; Zhenfeng Li; Abishek Chandrashekar; David R. Martinez; Carolin Loos; Caroline Atyeo; Stephanie Fischinger; John S. Burke; Matthew D. Slein; Yuezhou Chen; Adam Zuiani; Felipe J. N. Lelis; Meghan Travers; Shaghayegh Habibi; Laurent Pessaint; Alex Van Ry; Kelvin Blade; Renita Brown; Anthony Cook; Brad Finneyfrock; Alan Dodson; Elyse Teow; Jason Velasco; Roland Zahn; Frank Wegmann; Esther A. Bondzie; Gabriel Dagotto; Makda S. Gebre; Xuan He; Catherine Jacob-Dolan; Marinela Kirilova; Nicole Kordana; Zijin Lin; Lori F. Maxfield; Felix Nampanya; Ramya Nityanandam; John D. Ventura; Huahua Wan; Yongfei Cai; Bing Chen; Aaron G. Schmidt; Duane R. Wesemann; Ralph S. Baric; Galit Alter; Hanne Andersen; Mark G. Lewis; Dan H. Barouch
	2020-08-14
发表期刊	Science
出版年	2020
英文摘要	The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu et al. designed a series of prototype DNA vaccines against the SARS-CoV-2 spike protein, which is used by the virus to bind and invade human cells. Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the virus. Neutralizing antibody titers were also observed at levels similar to those seen in humans who have recovered from SARS-CoV-2 infection. Science , this issue p. [806][1] The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa, respectively, as compared with viral loads in sham controls. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates. [1]: /lookup/doi/10.1126/science.abc6284
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/288083
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jingyou Yu,Lisa H. Tostanoski,Lauren Peter,et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques[J]. Science,2020.
APA	Jingyou Yu.,Lisa H. Tostanoski.,Lauren Peter.,Noe B. Mercado.,Katherine McMahan.,...&Dan H. Barouch.(2020).DNA vaccine protection against SARS-CoV-2 in rhesus macaques.Science.
MLA	Jingyou Yu,et al."DNA vaccine protection against SARS-CoV-2 in rhesus macaques".Science (2020).