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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2 期刊论文
Science, 2021
作者:  Nir Drayman;  Jennifer K. DeMarco;  Krysten A. Jones;  Saara-Anne Azizi;  Heather M. Froggatt;  Kemin Tan;  Natalia Ivanovna Maltseva;  Siquan Chen;  Vlad Nicolaescu;  Steve Dvorkin;  Kevin Furlong;  Rahul S. Kathayat;  Mason R. Firpo;  Vincent Mastrodomenico;  Emily A. Bruce;  Madaline M. Schmidt;  Robert Jedrzejczak;  Miguel Á. Muñoz-Alía;  Brooke Schuster;  Vishnu Nair;  Kyu-yeon Han;  Amornrat O’Brien;  Anastasia Tomatsidou;  Bjoern Meyer;  Marco Vignuzzi;  Dominique Missiakas;  Jason W. Botten;  Christopher B. Brooke;  Hyun Lee;  Susan C. Baker;  Bryan C. Mounce;  Nicholas S. Heaton;  William E. Severson;  Kenneth E. Palmer;  Bryan C. Dickinson;  Andrzej Joachimiak;  Glenn Randall;  Savaş Tay
收藏  |  浏览/下载：13/0  |  提交时间：2021/08/25
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 期刊论文
Science, 2021
作者:  Tia A. Tummino;  Veronica V. Rezelj;  Benoit Fischer;  Audrey Fischer;  Matthew J. O’Meara;  Blandine Monel;  Thomas Vallet;  Kris M. White;  Ziyang Zhang;  Assaf Alon;  Heiko Schadt;  Henry R. O’Donnell;  Jiankun Lyu;  Romel Rosales;  Briana L. McGovern;  Raveen Rathnasinghe;  Sonia Jangra;  Michael Schotsaert;  Jean-René Galarneau;  Nevan J. Krogan;  Laszlo Urban;  Kevan M. Shokat;  Andrew C. Kruse;  Adolfo García-Sastre;  Olivier Schwartz;  Francesca Moretti;  Marco Vignuzzi;  Francois Pognan;  Brian K. Shoichet
收藏  |  浏览/下载：24/0  |  提交时间：2021/08/10
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A 期刊论文
Science, 2021
作者:  Kris M. White;  Romel Rosales;  Soner Yildiz;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Sonia Jangra;  Melissa B. Uccellini;  Raveen Rathnasinghe;  Lynda Coughlan;  Carles Martinez-Romero;  Jyoti Batra;  Ajda Rojc;  Mehdi Bouhaddou;  Jacqueline M. Fabius;  Kirsten Obernier;  Marion Dejosez;  María José Guillén;  Alejandro Losada;  Pablo Avilés;  Michael Schotsaert;  Thomas Zwaka;  Marco Vignuzzi;  Kevan M. Shokat;  Nevan J. Krogan;  Adolfo García-Sastre
收藏  |  浏览/下载：12/0  |  提交时间：2021/03/02
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike 期刊论文
Science, 2020
作者:  Michael Schoof;  Bryan Faust;  Reuben A. Saunders;  Smriti Sangwan;  Veronica Rezelj;  Nick Hoppe;  Morgane Boone;  Christian B. Billesbølle;  Cristina Puchades;  Caleigh M. Azumaya;  Huong T. Kratochvil;  Marcell Zimanyi;  Ishan Deshpande;  Jiahao Liang;  Sasha Dickinson;  Henry C. Nguyen;  Cynthia M. Chio;  Gregory E. Merz;  Michael C. Thompson;  Devan Diwanji;  Kaitlin Schaefer;  Aditya A. Anand;  Niv Dobzinski;  Beth Shoshana Zha;  Camille R. Simoneau;  Kristoffer Leon;  Kris M. White;  Un Seng Chio;  Meghna Gupta;  Mingliang Jin;  Fei Li;  Yanxin Liu;  Kaihua Zhang;  David Bulkley;  Ming Sun;  Amber M. Smith;  Alexandrea N. Rizo;  Frank Moss;  Axel F. Brilot;  Sergei Pourmal;  Raphael Trenker;  Thomas Pospiech;  Sayan Gupta;  Benjamin Barsi-Rhyne;  Vladislav Belyy;  Andrew W. Barile-Hill;  Silke Nock;  Yuwei Liu;  Nevan J. Krogan;  Corie Y. Ralston;  Danielle L. Swaney;  Adolfo García-Sastre;  Melanie Ott;  Marco Vignuzzi;  QCRG Structural Biology Consortium4‡;  Peter Walter;  Aashish Manglik
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载：23/0  |  提交时间：2020/12/07