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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 期刊论文
Science, 2020
作者:  Thomas W. Linsky;  Renan Vergara;  Nuria Codina;  Jorgen W. Nelson;  Matthew J. Walker;  Wen Su;  Christopher O. Barnes;  Tien-Ying Hsiang;  Katharina Esser-Nobis;  Kevin Yu;  Z. Beau Reneer;  Yixuan J. Hou;  Tanu Priya;  Masaya Mitsumoto;  Avery Pong;  Uland Y. Lau;  Marsha L. Mason;  Jerry Chen;  Alex Chen;  Tania Berrocal;  Hong Peng;  Nicole S. Clairmont;  Javier Castellanos;  Yu-Ru Lin;  Anna Josephson-Day;  Ralph S. Baric;  Deborah H. Fuller;  Carl D. Walkey;  Ted M. Ross;  Ryan Swanson;  Pamela J. Bjorkman;  Michael Gale;  Luis M. Blancas-Mejia;  Hui-Ling Yen;  Daniel-Adriano Silva
收藏  |  浏览/下载:11/0  |  提交时间:2020/12/07
Broad neutralization of SARS-related viruses by human monoclonal antibodies 期刊论文
Science, 2020
作者:  Anna Z. Wec;  Daniel Wrapp;  Andrew S. Herbert;  Daniel P. Maurer;  Denise Haslwanter;  Mrunal Sakharkar;  Rohit K. Jangra;  M. Eugenia Dieterle;  Asparouh Lilov;  Deli Huang;  Longping V. Tse;  Nicole V. Johnson;  Ching-Lin Hsieh;  Nianshuang Wang;  Juergen H. Nett;  Elizabeth Champney;  Irina Burnina;  Michael Brown;  Shu Lin;  Melanie Sinclair;  Carl Johnson;  Sarat Pudi;  Robert Bortz;  Ariel S. Wirchnianski;  Ethan Laudermilch;  Catalina Florez;  J. Maximilian Fels;  Cecilia M. O’Brien;  Barney S. Graham;  David Nemazee;  Dennis R. Burton;  Ralph S. Baric;  James E. Voss;  Kartik Chandran;  John M. Dye;  Jason S. McLellan;  Laura M. Walker
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/18
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
SYNTHETIC BIOLOGY A compact synthetic pathway rewires cancer signaling to therapeutic effector release 期刊论文
SCIENCE, 2019, 364 (6439) : 451-+
作者:  Chung, Hokyung K.;  Zou, Xinzhi;  Bajar, Bryce T.;  Brand, Veronica R.;  Huo, Yunwen;  Alcudia, Javier F.;  Ferrell, James E., Jr.;  Lin, Michael Z.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder 期刊论文
SCIENCE, 2018, 362 (6420) : 1270-+
作者:  An, Joon-Yong;  Lin, Kevin;  Zhu, Lingxue;  Werling, Donna M.;  Dong, Shan;  Brand, Harrison;  Wang, Harold Z.;  Zhao, Xuefang;  Schwartz, Grace B.;  Collins, Ryan L.;  Currall, Benjamin B.;  Dastmalchi, Claudia;  Dea, Jeanselle;  Duhn, Clif;  Gilson, Michael C.;  Klei, Lambertus;  Liang, Lindsay;  Markenscoff-Papadimitriou, Eirene;  Pochareddy, Sirisha;  Ahituv, Nadav;  Buxbaum, Joseph D.;  Coon, Hilary;  Daly, Mark J.;  Kim, Young Shin;  Marth, Gabor T.;  Neale, Benjamin M.;  Quinlan, Aaron R.;  Rubenstein, John L.;  Sestan, Nenad;  State, Matthew W.;  Willsey, A. Jeremy;  Talkowski, Michael E.;  Devlin, Bernie;  Roeder, Kathryn;  Sanders, Stephan J.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Understanding CRY2 interactions for optical control of intracellular signaling 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Duan, Liting;  Hope, Jen;  Ong, Qunxiang;  Lou, Hsin-Ya;  Kim, Namdoo;  McCarthy, Comfrey;  Acero, Victor;  Lin, Michael Z.;  Cui, Bianxiao
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Optical control of cell signaling by single-chain photoswitchable kinases 期刊论文
SCIENCE, 2017, 355 (6327) : 836-841
作者:  Zhou, Xin X.;  Fan, Linlin Z.;  Li, Pengpeng;  Shen, Kang;  Lin, Michael Z.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27