Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat6982 |
SYNTHETIC BIOLOGY A compact synthetic pathway rewires cancer signaling to therapeutic effector release | |
Chung, Hokyung K.1,2,3; Zou, Xinzhi4; Bajar, Bryce T.3,4; Brand, Veronica R.3,4; Huo, Yunwen2,3,4; Alcudia, Javier F.5; Ferrell, James E., Jr.6; Lin, Michael Z.2,3,4,6 | |
2019-05-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:451-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | An important goal in synthetic biology is to engineer biochemical pathways to address unsolved biomedical problems. One long-standing problem in molecular medicine is the specific identification and ablation of cancer cells. Here, we describe a method, named Rewiring of Aberrant Signaling to Effector Release (RASER), in which oncogenic ErbB receptor activity, instead of being targeted for inhibition as in existing treatments, is co-opted to trigger therapeutic programs. RASER integrates ErbB activity to specifically link oncogenic states to the execution of desired outputs. A complete mathematical model of RASER and modularity in design enable rational optimization and output programming. Using RASER, we induced apoptosis and CRISPR-Cas9-mediated transcription of endogenous genes specifically in ErbB-hyperactive cancer cells. Delivery of apoptotic RASER by adeno-associated virus selectively ablated ErbB-hyperactive cancer cells while sparing ErbB-normal cells. RASER thus provides a new strategy for oncogene-specific cancer detection and treatment. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600023 |
WOS关键词 | GROWTH-FACTOR RECEPTOR ; ERBB RECEPTORS ; GENE CIRCUITS ; LUNG-CANCER ; CELL ; SPECIFICITY ; ACTIVATION ; EXPRESSION ; MECHANISM ; PROTEASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201356 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA; 3.Stanford Univ, Dept Pediat, Stanford, CA 94305 USA; 4.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 5.Stanford Univ, Neurosci Gene Vector & Virus Core, Stanford, CA USA; 6.Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Chung, Hokyung K.,Zou, Xinzhi,Bajar, Bryce T.,et al. SYNTHETIC BIOLOGY A compact synthetic pathway rewires cancer signaling to therapeutic effector release[J]. SCIENCE,2019,364(6439):451-+. |
APA | Chung, Hokyung K..,Zou, Xinzhi.,Bajar, Bryce T..,Brand, Veronica R..,Huo, Yunwen.,...&Lin, Michael Z..(2019).SYNTHETIC BIOLOGY A compact synthetic pathway rewires cancer signaling to therapeutic effector release.SCIENCE,364(6439),451-+. |
MLA | Chung, Hokyung K.,et al."SYNTHETIC BIOLOGY A compact synthetic pathway rewires cancer signaling to therapeutic effector release".SCIENCE 364.6439(2019):451-+. |
条目包含的文件 | 条目无相关文件。 |
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