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Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni 期刊论文
Science, 2020
作者:  Jipeng Wang;  Carlos Paz;  Gilda Padalino;  Avril Coghlan;  Zhigang Lu;  Irina Gradinaru;  Julie N. R. Collins;  Matthew Berriman;  Karl F. Hoffmann;  James J. Collins
收藏  |  浏览/下载:9/0  |  提交时间:2020/09/30
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Enamel proteome shows that Gigantopithecus was an early diverging pongine 期刊论文
Nature, 2019, 575
作者:  Frido Welker;  Jazm铆n Ramos-Madrigal;  Martin Kuhlwilm;  Wei Liao;  Petra Gutenbrunner;  Marc de Manuel;  Diana Samodova;  Meaghan Mackie;  Morten E. Allentoft;  Anne-Marie Bacon;  Matthew J. Collins;  J眉rgen Cox;  Carles Lalueza-Fox;  Jesper V. Olsen;  Fabrice Demeter;  Wei Wang;  Tomas Marques-Bonet;  Enrico Cappellini
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Alternatives to genetic affinity as a context for within-species response to climate 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (10) : 787-+
作者:  Smith, Adam B.;  Beever, Erik A.;  Kessler, Aimee E.;  Johnston, Aaron N.;  Ray, Chris;  Epps, Clinton W.;  Lanier, Hayley C.;  Klinger, Rob C.;  Rodhouse, Thomas J.;  Varner, Johanna;  Perrine, John D.;  Seglund, Amy;  Hall, L. Embere;  Galbreath, Kurt;  MacGlover, Chris;  Billman, Peter;  Blatz, Gretchen;  Brewer, Jason;  Vardaro, Jessica Castillo;  Chalfoun, Anna D.;  Collins, Gail;  Craighead, April;  Curlis, Chris;  Daly, Christopher;  Doak, Daniel F.;  East, Mitch;  Edwards, Mark;  Erb, Liesl;  Ernest, Kristina A.;  Fauver, Brian;  Foresman, Kerry R.;  Goehring, Ken;  Hagar, Joan;  Hayes, Charles L.;  Henry, Philippe;  Hersey, Kimberly;  Hilty, Shannon L.;  Jacobson, Jim;  Jeffress, Mackenzie R.;  Manning, Tom;  Masching, Amy;  Maxell, Bryce;  McCollough, Rayo;  McFarland, Corrie;  Miskow, Eric;  Morelli, Toni Lyn;  Moyer-Horner, Lucas;  Mueller, Megan;  Nugent, Martin;  Pratt, Beth;  Rasmussen-Flores, Mary;  Rickman, Tom H.;  Robison, Hillary;  Rodriguez, Arthur;  Rowe, Karen;  Rowe, Kevin;  Russello, Michael A.;  Saab, Vicki;  Schmidt, Angie;  Stewart, Joseph A. E.;  Stuart, James N.;  Svancara, Leona K.;  Thompson, Will;  Timmins, Julie;  Treinish, Gregg;  Waterhouse, Matthew D.;  Westover, Marie L.;  Wilkening, Jennifer;  Yandow, Leah
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent 期刊论文
SCIENCE, 2019, 365 (6449) : 173-+
作者:  Verdugo, Marta Pereira;  Mullin, Victoria E.;  Scheu, Amelie;  Mattiangeli, Valeria;  Daly, Kevin G.;  Delser, Pierpaolo Maisano;  Hare, Andrew J.;  Burger, Joachim;  Collins, Matthew J.;  Kehati, Ron;  Hesse, Paula;  Fulton, Deirdre;  Sauer, Eberhard W.;  Mohaseb, Fatemeh A.;  Davoudi, Hossein;  Khazaeli, Roya;  Lhuillier, Johanna;  Rapin, Claude;  Ebrahimi, Saeed;  Khasanov, Mutalib;  Vahidi, S. M. Farhad;  MacHugh, David E.;  Ertugrul, Okan;  Koukouli-Chrysanthaki, Chaido;  Sampson, Adamantios;  Kazantzis, George;  Kontopoulos, Ioannis;  Bulatovic, Jelena;  Stojanovic, Ivana;  Mikdad, Abdesalam;  Benecke, Norbert;  Linstaedter, Joerg;  Sablin, Mikhail;  Bendrey, Robin;  Gourichon, Lionel;  Arbuckle, Benjamin S.;  Mashkour, Marjan;  Orton, David;  Horwitz, Liora Kolska;  Teasdale, Matthew D.;  Bradley, Daniel G.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Integrating Species-Specific Information in Models Improves Regional Projections Under Climate Change 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (12) : 6554-6562
作者:  Remy, Cecile C.;  Krofcheck, Dan J.;  Keyser, Alisa R.;  Litvak, Marcy E.;  Collins, Scott L.;  Hurteau, Matthew D.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/26
LANDIS-II  PnET-succession  eddy-covariance  North America southwest  carbon  climate change  
Global Mean Surface Temperature Response to Large-Scale Patterns of Variability in Observations and CMIP5 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (4) : 2232-2241
作者:  Kajtar, Jules B.;  Collins, Matthew;  Frankcombe, Leela M.;  England, Matthew H.;  Osborn, Timothy J.;  Juniper, Marcus
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry 期刊论文
SCIENCE, 2019, 363 (6429) : 838-+
作者:  Peters, Byron K.;  Rodriguez, Kevin X.;  Reisberg, Solomon H.;  Beil, Sebastian B.;  Hickey, David P.;  Kawamata, Yu;  Collins, Michael;  Starr, Jeremy;  Chen, Longrui;  Udyavara, Sagar;  Klunder, Kevin;  Gorey, Timothy J.;  Anderson, Scott L.;  Neurock, Matthew;  Minteer, Shelley D.;  Baran, Phil S.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder 期刊论文
SCIENCE, 2018, 362 (6420) : 1270-+
作者:  An, Joon-Yong;  Lin, Kevin;  Zhu, Lingxue;  Werling, Donna M.;  Dong, Shan;  Brand, Harrison;  Wang, Harold Z.;  Zhao, Xuefang;  Schwartz, Grace B.;  Collins, Ryan L.;  Currall, Benjamin B.;  Dastmalchi, Claudia;  Dea, Jeanselle;  Duhn, Clif;  Gilson, Michael C.;  Klei, Lambertus;  Liang, Lindsay;  Markenscoff-Papadimitriou, Eirene;  Pochareddy, Sirisha;  Ahituv, Nadav;  Buxbaum, Joseph D.;  Coon, Hilary;  Daly, Mark J.;  Kim, Young Shin;  Marth, Gabor T.;  Neale, Benjamin M.;  Quinlan, Aaron R.;  Rubenstein, John L.;  Sestan, Nenad;  State, Matthew W.;  Willsey, A. Jeremy;  Talkowski, Michael E.;  Devlin, Bernie;  Roeder, Kathryn;  Sanders, Stephan J.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Heat flow and thermal conductivity measurements in the northeastern Pennsylvania Appalachian Basin depocenter 期刊论文
AAPG BULLETIN, 2018, 102 (11) : 2155-2170
作者:  Rauch, Chelsea;  Barrie, Kyle;  Collins, Steven C.;  Hornbach, Matthew J.;  Brokaw, Casey
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09