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DOI | 10.1038/s41586-019-1728-8 |
Enamel proteome shows that Gigantopithecus was an early diverging pongine | |
Frido Welker; Jazm铆n Ramos-Madrigal; Martin Kuhlwilm; Wei Liao; Petra Gutenbrunner; Marc de Manuel; Diana Samodova; Meaghan Mackie; Morten E. Allentoft; Anne-Marie Bacon; Matthew J. Collins; J眉rgen Cox; Carles Lalueza-Fox; Jesper V. Olsen; Fabrice Demeter; Wei Wang; Tomas Marques-Bonet; Enrico Cappellini | |
2019-11-13 | |
发表期刊 | Nature |
出版年 | 2019 |
卷号 | 575 |
英文摘要 | Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene聽epoch (16鈥?.3 million years ago), remain unclear2,3. Hypotheses regarding the relationships between Gigantopithecus and extinct and extant hominids are wide ranging but difficult to substantiate because of its highly derived dentognathic morphology, the absence of cranial and post-cranial remains1,3,4,5,6, and the lack of independent molecular validation. We retrieved dental enamel proteome sequences from a 1.9-million-year-old G. blacki molar found in Chuifeng Cave, China7,8. The thermal age of these protein sequences is approximately five times greater than that of any previously published mammalian proteome or genome. We demonstrate that Gigantopithecus is a sister clade to orangutans (genus Pongo) with a common ancestor about 12鈥?0聽million years ago, implying that the divergence of Gigantopithecus from Pongo forms part of the Miocene radiation of great apes. In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns that characterize the large molars in Gigantopithecus9,10. The survival of an Early Pleistocene dental enamel proteome in the subtropics further expands the scope of palaeoproteomic analysis into geographical areas and time periods previously considered incompatible with the preservation of substantial amounts of genetic information. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203156 |
专题 | 地球科学 资源环境科学 气候变化 |
推荐引用方式 GB/T 7714 | Frido Welker,Jazm铆n Ramos-Madrigal,Martin Kuhlwilm,et al. Enamel proteome shows that Gigantopithecus was an early diverging pongine[J]. Nature,2019,575. |
APA | Frido Welker.,Jazm铆n Ramos-Madrigal.,Martin Kuhlwilm.,Wei Liao.,Petra Gutenbrunner.,...&Enrico Cappellini.(2019).Enamel proteome shows that Gigantopithecus was an early diverging pongine.Nature,575. |
MLA | Frido Welker,et al."Enamel proteome shows that Gigantopithecus was an early diverging pongine".Nature 575(2019). |
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