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Population sequencing data reveal a compendium of mutational processes in the human germ line 期刊论文
Science, 2021
作者:  Vladimir B. Seplyarskiy;  Ruslan A. Soldatov;  Evan Koch;  Ryan J. McGinty;  Jakob M. Goldmann;  Ryan D. Hernandez;  Kathleen Barnes;  Adolfo Correa;  Esteban G. Burchard;  Patrick T. Ellinor;  Stephen T. McGarvey;  Braxton D. Mitchell;  Ramachandran S. Vasan;  Susan Redline;  Edwin Silverman;  Scott T. Weiss;  Donna K. Arnett;  John Blangero;  Eric Boerwinkle;  Jiang He;  Courtney Montgomery;  D. C. Rao;  Jerome I. Rotter;  Kent D. Taylor;  Jennifer A. Brody;  Yii-Der Ida Chen;  Lisa de las Fuentes;  Chii-Min Hwu;  Stephen S. Rich;  Ani W. Manichaikul;  Josyf C. Mychaleckyj;  Nicholette D. Palmer;  Jennifer A. Smith;  Sharon L. R. Kardia;  Patricia A. Peyser;  Lawrence F. Bielak;  Timothy D. O’Connor;  Leslie S. Emery;  NHLBI Trans-Omics for Precision Medicine Consortium‡;  TOPMed Population Genetics Working Group;  Christian Gilissen;  Wendy S. W. Wong;  Peter V. Kharchenko;  Shamil Sunyaev
收藏  |  浏览/下载:13/0  |  提交时间:2021/08/30
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2 期刊论文
Science, 2021
作者:  Nir Drayman;  Jennifer K. DeMarco;  Krysten A. Jones;  Saara-Anne Azizi;  Heather M. Froggatt;  Kemin Tan;  Natalia Ivanovna Maltseva;  Siquan Chen;  Vlad Nicolaescu;  Steve Dvorkin;  Kevin Furlong;  Rahul S. Kathayat;  Mason R. Firpo;  Vincent Mastrodomenico;  Emily A. Bruce;  Madaline M. Schmidt;  Robert Jedrzejczak;  Miguel Á. Muñoz-Alía;  Brooke Schuster;  Vishnu Nair;  Kyu-yeon Han;  Amornrat O’Brien;  Anastasia Tomatsidou;  Bjoern Meyer;  Marco Vignuzzi;  Dominique Missiakas;  Jason W. Botten;  Christopher B. Brooke;  Hyun Lee;  Susan C. Baker;  Bryan C. Mounce;  Nicholas S. Heaton;  William E. Severson;  Kenneth E. Palmer;  Bryan C. Dickinson;  Andrzej Joachimiak;  Glenn Randall;  Savaş Tay
收藏  |  浏览/下载:13/0  |  提交时间:2021/08/25
Core commitments for field trials of gene drive organisms 期刊论文
Science, 2020
作者:  Kanya C. Long;  Luke Alphey;  George J. Annas;  Cinnamon S. Bloss;  Karl J. Campbell;  Jackson Champer;  Chun-Hong Chen;  Amit Choudhary;  George M. Church;  James P. Collins;  Kimberly L. Cooper;  Jason A. Delborne;  Owain R. Edwards;  Claudia I. Emerson;  Kevin Esvelt;  Sam Weiss Evans;  Robert M. Friedman;  Valentino M. Gantz;  Fred Gould;  Sarah Hartley;  Elizabeth Heitman;  Janet Hemingway;  Hirotaka Kanuka;  Jennifer Kuzma;  James V. Lavery;  Yoosook Lee;  Marce Lorenzen;  Jeantine E. Lunshof;  John M. Marshall;  Philipp W. Messer;  Craig Montell;  Kenneth A. Oye;  Megan J. Palmer;  Philippos Aris Papathanos;  Prasad N. Paradkar;  Antoinette J. Piaggio;  Jason L. Rasgon;  Gordana Rašić;  Larisa Rudenko;  J. Royden Saah;  Maxwell J. Scott;  Jolene T. Sutton;  Adam E. Vorsino;  Omar S. Akbari
收藏  |  浏览/下载:23/0  |  提交时间:2020/12/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:25/0  |  提交时间:2020/12/07
Determinants of telomere length across human tissues 期刊论文
Science, 2020
作者:  Kathryn Demanelis;  Farzana Jasmine;  Lin S. Chen;  Meytal Chernoff;  Lin Tong;  Dayana Delgado;  Chenan Zhang;  Justin Shinkle;  Mekala Sabarinathan;  Hannah Lin;  Eduardo Ramirez;  Meritxell Oliva;  Sarah Kim-Hellmuth;  Barbara E. Stranger;  Tsung-Po Lai;  Abraham Aviv;  Kristin G. Ardlie;  François Aguet;  Habibul Ahsan;  GTEx Consortium*;  Jennifer A. Doherty;  Muhammad G. Kibriya;  Brandon L. Pierce
收藏  |  浏览/下载:10/0  |  提交时间:2020/09/14
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Megahertz serial crystallography 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Wiedorn, Max O.;  Oberthuer, Dominik;  Bean, Richard;  Schubert, Robin;  Werner, Nadine;  Abbey, Brian;  Aepfelbacher, Martin;  Adriano, Luigi;  Allahgholi, Aschkan;  Al-Qudami, Nasser;  Andreasson, Jakob;  Aplin, Steve;  Awel, Salah;  Ayyer, Kartik;  Bajt, Sasa;  Barak, Imrich;  Bari, Sadia;  Bielecki, Johan;  Botha, Sabine;  Boukhelef, Djelloul;  Brehm, Wolfgang;  Brockhauser, Sandor;  Cheviakov, Igor;  Coleman, Matthew A.;  Cruz-Mazo, Francisco;  Danilevski, Cyril;  Darmanin, Connie;  Doak, R. Bruce;  Domaracky, Martin;  Doerner, Katerina;  Du, Yang;  Fangohr, Hans;  Fleckenstein, Holger;  Frank, Matthias;  Fromme, Petra;  Ganan-Calvo, Alfonso M.;  Gevorkov, Yaroslav;  Giewekemeyer, Klaus;  Ginn, Helen Mary;  Graafsma, Heinz;  Graceffa, Rita;  Greiffenberg, Dominic;  Gumprecht, Lars;  Goettlicher, Peter;  Hajdu, Janos;  Hauf, Steffen;  Heymann, Michael;  Holmes, Susannah;  Horke, Daniel A.;  Hunter, Mark S.;  Imlau, Siegfried;  Kaukher, Alexander;  Kim, Yoonhee;  Klyuev, Alexander;  Knoska, Juraj;  Kobe, Bostjan;  Kuhn, Manuela;  Kupitz, Christopher;  Kuepper, Jochen;  Lahey-Rudolph, Janine Mia;  Laurus, Torsten;  Le Cong, Karoline;  Letrun, Romain;  Xavier, P. Lourdu;  Maia, Luis;  Maia, Filipe R. N. C.;  Mariani, Valerio;  Messerschmidt, Marc;  Metz, Markus;  Mezza, Davide;  Michelat, Thomas;  Mills, Grant;  Monteiro, Diana C. F.;  Morgan, Andrew;  Muhlig, Kerstin;  Munke, Anna;  Muennich, Astrid;  Nette, Julia;  Nugent, Keith A.;  Nuguid, Theresa;  Orville, Allen M.;  Pandey, Suraj;  Pena, Gisel;  Villanueva-Perez, Pablo;  Poehlsen, Jennifer;  Previtali, Gianpietro;  Redecke, Lars;  Riekehr, Winnie Maria;  Rohde, Holger;  Round, Adam;  Safenreiter, Tatiana;  Sarrou, Iosifina;  Sato, Tokushi;  Schmidt, Marius;  Schmitt, Bernd;  Schoenherr, Robert;  Schulz, Joachim;  Sellberg, Jonas A.;  Seibert, M. Marvin;  Seuring, Carolin;  Shelby, Megan L.;  Shoeman, Robert L.;  Sikorski, Marcin;  Silenzi, Alessandro;  Stan, Claudiu A.;  Shi, Xintian;  Stern, Stephan;  Sztuk-Dambietz, Jola;  Szuba, Janusz;  Tolstikova, Aleksandra;  Trebbin, Martin;  Trunk, Ulrich;  Vagovic, Patrik;  Ve, Thomas;  Weinhausen, Britta;  White, Thomas A.;  Wrona, Krzysztof;  Xu, Chen;  Yefanov, Oleksandr;  Zatsepin, Nadia;  Zhang, Jiaguo;  Perbandt, Markus;  Mancuso, Adrian P.;  Betzel, Christian;  Chapman, Henry;  Barty, Anton
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27
Identification of a T follicular helper cell subset that drives anaphylactic IgE 期刊论文
SCIENCE, 2019, 365 (6456) : 883-+
作者:  Gowthaman, Uthaman;  Chen, Jennifer S.;  Zhang, Biyan;  Flynn, William F.;  Lu, Yisi;  Song, Wenzhi;  Joseph, Julie;  Gertie, Jake A.;  Xu, Lan;  Collet, Magalie A.;  Grassmann, Jessica D. S.;  Simoneau, Tregony;  Chiang, David;  Berin, M. Cecilia;  Craft, Joseph E.;  Weinstein, Jason S.;  Williams, Adam;  Eisenbarth, Stephanie C.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Rashid, Mamunur;  van der Horst, Michiel;  Mentzel, Thomas;  Butera, Francesca;  Ferreira, Ingrid;  Pance, Alena;  Rutten, Arno;  Luzar, Bostjan;  Marusic, Zlatko;  Aubain, Nicolas de Saint;  Ko, Jennifer S.;  Billings, Steven D.;  Chen, Sofia;  Daoud, Marie Abi;  Hewinson, James;  Louzada, Sandra;  Harms, Paul W.;  Cerretelli, Guia;  Robles-Espinoza, Carla Daniela;  Patel, Rajiv M.;  van der Weyden, Louise;  Bakal, Chris;  Hornick, Jason L.;  Arends, Mark J.;  Brenn, Thomas;  Adams, David J.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes 期刊论文
SCIENCE, 2018, 362 (6416) : 839-+
作者:  Harrington, Lucas B.;  Burstein, David;  Chen, Janice S.;  Paez-Espino, David;  Ma, Enbo;  Witte, Isaac P.;  Cofsky, Joshua C.;  Kyrpides, Nikos C.;  Banfield, Jillian F.;  Doudna, Jennifer A.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27