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Accurate prediction of protein structures and interactions using a three-track neural network 期刊论文
Science, 2021
作者:  Minkyung Baek;  Frank DiMaio;  Ivan Anishchenko;  Justas Dauparas;  Sergey Ovchinnikov;  Gyu Rie Lee;  Jue Wang;  Qian Cong;  Lisa N. Kinch;  R. Dustin Schaeffer;  Claudia Millán;  Hahnbeom Park;  Carson Adams;  Caleb R. Glassman;  Andy DeGiovanni;  Jose H. Pereira;  Andria V. Rodrigues;  Alberdina A. van Dijk;  Ana C. Ebrecht;  Diederik J. Opperman;  Theo Sagmeister;  Christoph Buhlheller;  Tea Pavkov-Keller;  Manoj K. Rathinaswamy;  Udit Dalwadi;  Calvin K. Yip;  John E. Burke;  K. Christopher Garcia;  Nick V. Grishin;  Paul D. Adams;  Randy J. Read;  David Baker
收藏  |  浏览/下载:18/0  |  提交时间:2021/08/25
Transporter characterisation reveals aminoethylphosphonate mineralisation as a key step in the marine phosphorus redox cycle 期刊论文
Nature Communications, 2021
作者:  Murphy, Andrew R. J.;  Scanlan, David J.;  Chen, Yin;  Adams, Nathan B. P.;  Cadman, William A.;  Bottrill, Andrew;  Bending, Gary;  Hammond, John P.;  Hitchcock, Andrew;  Wellington, Elizabeth M. H.;  Lidbury, Ian D. E. A.
收藏  |  浏览/下载:12/0  |  提交时间:2021/08/10
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events 期刊论文
Science, 2021
作者:  Jacob E. Lemieux;  Katherine J. Siddle;  Bennett M. Shaw;  Christine Loreth;  Stephen F. Schaffner;  Adrianne Gladden-Young;  Gordon Adams;  Timelia Fink;  Christopher H. Tomkins-Tinch;  Lydia A. Krasilnikova;  Katherine C. DeRuff;  Melissa Rudy;  Matthew R. Bauer;  Kim A. Lagerborg;  Erica Normandin;  Sinéad B. Chapman;  Steven K. Reilly;  Melis N. Anahtar;  Aaron E. Lin;  Amber Carter;  Cameron Myhrvold;  Molly E. Kemball;  Sushma Chaluvadi;  Caroline Cusick;  Katelyn Flowers;  Anna Neumann;  Felecia Cerrato;  Maha Farhat;  Damien Slater;  Jason B. Harris;  John A. Branda;  David Hooper;  Jessie M. Gaeta;  Travis P. Baggett;  James O’Connell;  Andreas Gnirke;  Tami D. Lieberman;  Anthony Philippakis;  Meagan Burns;  Catherine M. Brown;  Jeremy Luban;  Edward T. Ryan;  Sarah E. Turbett;  Regina C. LaRocque;  William P. Hanage;  Glen R. Gallagher;  Lawrence C. Madoff;  Sandra Smole;  Virginia M. Pierce;  Eric Rosenberg;  Pardis C. Sabeti;  Daniel J. Park;  Bronwyn L. MacInnis
收藏  |  浏览/下载:18/0  |  提交时间:2021/02/17
A triple-star system with a misaligned and warped circumstellar disk shaped by disk tearing 期刊论文
Science, 2020
作者:  Stefan Kraus;  Alexander Kreplin;  Alison K. Young;  Matthew R. Bate;  John D. Monnier;  Tim J. Harries;  Henning Avenhaus;  Jacques Kluska;  Anna S. E. Laws;  Evan A. Rich;  Matthew Willson;  Alicia N. Aarnio;  Fred C. Adams;  Sean M. Andrews;  Narsireddy Anugu;  Jaehan Bae;  Theo ten Brummelaar;  Nuria Calvet;  Michel Curé;  Claire L. Davies;  Jacob Ennis;  Catherine Espaillat;  Tyler Gardner;  Lee Hartmann;  Sasha Hinkley;  Aaron Labdon;  Cyprien Lanthermann;  Jean-Baptiste LeBouquin;  Gail H. Schaefer;  Benjamin R. Setterholm;  David Wilner;  Zhaohuan Zhu
收藏  |  浏览/下载:8/0  |  提交时间:2020/09/08
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Blake, Kimbria J.;  Baral, Pankaj;  Voisin, Tiphaine;  Lubkin, Ashira;  Pinho-Ribeiro, Felipe Almeida;  Adams, Kelsey L.;  Roberson, David P.;  Ma, Yuxin C.;  Otto, Michael;  Woolf, Clifford J.;  Torres, Victor J.;  Chiu, Isaac M.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Wang, Yidong;  Wu, Bingruo;  Lu, Pengfei;  Zhang, Donghong;  Wu, Brian;  Varshney, Shweta;  del Monte-Nieto, Gonzalo;  Zhuang, Zhenwu;  Charafeddine, Rabab;  Kramer, Adam H.;  Sibinga, Nicolas E.;  Frangogiannis, Nikolaos G.;  Kitsis, Richard N.;  Adams, Ralf H.;  Alitalo, Kari;  Sharp, David J.;  Harvey, Richard P.;  Stanley, Pamela;  Zhou, Bin
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Drought supersedes warming in determining volatile and tissue defenses of pinon pine (Pinus edulis) 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (6)
作者:  Trowbridge, Amy M.;  Stoy, Paul C.;  Adams, Henry D.;  Law, Darin J.;  Breshears, David D.;  Helmig, Detlev;  Monson, Russell K.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
drought  heat stress  monoterpenes  Pinus edulis  plant defense  secondary metabolites  volatile organic compounds  
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Rashid, Mamunur;  van der Horst, Michiel;  Mentzel, Thomas;  Butera, Francesca;  Ferreira, Ingrid;  Pance, Alena;  Rutten, Arno;  Luzar, Bostjan;  Marusic, Zlatko;  Aubain, Nicolas de Saint;  Ko, Jennifer S.;  Billings, Steven D.;  Chen, Sofia;  Daoud, Marie Abi;  Hewinson, James;  Louzada, Sandra;  Harms, Paul W.;  Cerretelli, Guia;  Robles-Espinoza, Carla Daniela;  Patel, Rajiv M.;  van der Weyden, Louise;  Bakal, Chris;  Hornick, Jason L.;  Arends, Mark J.;  Brenn, Thomas;  Adams, David J.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Integrated biostratigraphy and carbon isotope stratigraphy for the Upper Cretaceous Kanguk Formation of the High Arctic Sverdrup Basin, Canada 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2018, 130: 1540-1561
作者:  Davies, Marissa A.;  Schroder-Adams, Claudia J.;  Herrle, Jens O.;  Hulse, Peter;  Schneider, Simon;  Quesnel, Alex;  Harwood, David M.
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09