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Statistical Characteristics in the Spectrum of Whistler Waves near the Diffusion Region of dayside Magnetopause Reconnection 期刊论文
Geophysical Research Letters, 2020
作者:  Y. Ren;  L. Dai;  C.Wang;  W. Li;  X. Tao;  B. Lavraud;  O. Le Contel
收藏  |  浏览/下载:13/0  |  提交时间:2020/12/22
Tectonic transition from oceanic subduction to continental collision: New geochemical evidence from Early-Middle Triassic mafic igneous rocks in southern Liaodong Peninsula, east-central China 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1469-1488
作者:  Fang, Wei;  Dai, Li-Qun;  Zheng, Yong-Fei;  Zhao, Zi-Fu;  Ma, Li-Tao
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
PIRs mediate innate myeloid cell memory to nonself MHC molecules 期刊论文
Science, 2020
作者:  Hehua Dai;  Peixiang Lan;  Daqiang Zhao;  Khodor Abou-Daya;  Wentao Liu;  Wenhao Chen;  Andrew J. Friday;  Amanda L. Williams;  Tao Sun;  Jianjiao Chen;  Wei Chen;  Steven Mortin-Toth;  Jayne S. Danska;  Chris Wiebe;  Peter Nickerson;  Tengfang Li;  Lisa R. Mathews;  Hêth R. Turnquist;  Matthew L. Nicotra;  Sebastien Gingras;  Eiji Takayama;  Hiromi Kubagawa;  Mark J. Shlomchik;  Martin H. Oberbarnscheidt;  Xian C. Li;  Fadi G. Lakkis
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/09
Depth‐dependent soil organic carbon dynamics of croplands across the Chengdu Plain of China from the 1980s to the 2010s 期刊论文
Global Change Biology, 2020
作者:  Qiquan Li;  Aiwen Li;  Tianfei Dai;  Zemeng Fan;  Youlin Luo;  Shan Li;  Dagang Yuan;  Bin Zhao;  Qi Tao;  Changquan Wang;  Bing Li;  Xuesong Gao;  Yiding Li;  Huanxiu Li;  John P. Wilson
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Dissecting primate early post-implantation development using long-term in vitro embryo culture 期刊论文
SCIENCE, 2019, 366 (6467) : 837-+
作者:  Niu, Yuyu;  Sun, Nianqin;  Li, Chang;  Lei, Ying;  Huang, Zhihao;  Wu, Jun;  Si, Chenyang;  Dai, Xi;  Liu, Chuanyu;  Wei, Jingkuan;  Liu, Longqi;  Feng, Su;  Kang, Yu;  Si, Wei;  Wang, Hong;  Zhang, E.;  Zhao, Lu;  Li, Ziwei;  Luo, Xi;  Cui, Guizhong;  Peng, Guangdun;  Belmonte, Juan Carlos Izpisua;  Ji, Weizhi;  Tan, Tao
收藏  |  浏览/下载:17/0  |  提交时间:2020/02/17
Twenty-Five Years of Lower Tropospheric Ozone Observations in Tropical East Asia: The Influence of Emissions and Weather Patterns 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Wang, Tao;  Dai, Jianing;  Lam, Ka Se;  Nan Poon, Chun;  Brasseur, Guy P.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
tropospheric ozone  driving factors  emissions  climate  East Asia  carbon monoxide  
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yu, Tao;  Gan, Shucheng;  Zhu, Qingchen;  Dai, Dongfang;  Li, Ni;  Wang, Hui;  Chen, Xiaosong;  Hou, Dan;  Wang, Yan;  Pan, Qiang;  Xu, Jing;  Zhang, Xingli;  Liu, Junli;  Pei, Siyu;  Peng, Chao;  Wu, Ping;  Romano, Simona;  Mao, Chaoming;  Huang, Mingzhu;  Zhu, Xiaodong;  Shen, Kunwei;  Qin, Jun;  Xiao, Yichuan
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Internal Drainage Has Sustained Low-Relief Tibetan Landscapes Since the Early Miocene 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (15) : 8741-8752
作者:  Han, Zhongpeng;  Sinclair, Hugh D.;  Li, Yalin;  Wang, Chengshan;  Tao, Zui;  Qian, Xinyu;  Ning, Zijie;  Zhang, Jiawei;  Wen, Yixiong;  Lin, Jie;  Zhang, Baosen;  Xu, Ming;  Dai, Jingen;  Zhou, Aorigele;  Liang, Huimin;  Cao, Shuo
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27