PIRs mediate innate myeloid cell memory to nonself MHC molecules

doi:10.1126/science.aax4040

GSTDTAP > 气候变化

DOI	10.1126/science.aax4040
	PIRs mediate innate myeloid cell memory to nonself MHC molecules
	Hehua Dai; Peixiang Lan; Daqiang Zhao; Khodor Abou-Daya; Wentao Liu; Wenhao Chen; Andrew J. Friday; Amanda L. Williams; Tao Sun; Jianjiao Chen; Wei Chen; Steven Mortin-Toth; Jayne S. Danska; Chris Wiebe; Peter Nickerson; Tengfang Li; Lisa R. Mathews; Hêth R. Turnquist; Matthew L. Nicotra; Sebastien Gingras; Eiji Takayama; Hiromi Kubagawa; Mark J. Shlomchik; Martin H. Oberbarnscheidt; Xian C. Li; Fadi G. Lakkis
	2020-06-05
发表期刊	Science
出版年	2020
英文摘要	Immunological memory is a phenomenon by which immune cells can quickly recognize an antigen that the host has previously encountered. Certain cells of the innate immune system exhibit memory-like responses know as trained immunity. Rapid, antigen-specific secondary (anamnestic) responses were long thought to be the domain of B and T cells. However, Dai et al. report that monocytes and macrophages can acquire memory specific for particular major histocompatibility complex I antigens using paired A-type immunoglobulin-like receptors (PIR-As) (see the Perspective by Dominguez-Andrés and Netea). This pathway contributes to recognition and rejection of allograft-transplanted tissue from a donor of the same species. Genetic depletion or blockade of PIR-As in mice diminished the rejection of kidney and heart allografts. This work, which expands immunological memory to include myeloid cells, points to targets that may improve organ transplantation outcomes in the future. Science , this issue p. [1122][1]; see also p. [1052][2] Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes. [1]: /lookup/doi/10.1126/science.aax4040 [2]: /lookup/doi/10.1126/science.abc2660
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/273446
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Hehua Dai,Peixiang Lan,Daqiang Zhao,et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules[J]. Science,2020.
APA	Hehua Dai.,Peixiang Lan.,Daqiang Zhao.,Khodor Abou-Daya.,Wentao Liu.,...&Fadi G. Lakkis.(2020).PIRs mediate innate myeloid cell memory to nonself MHC molecules.Science.
MLA	Hehua Dai,et al."PIRs mediate innate myeloid cell memory to nonself MHC molecules".Science (2020).