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DOI | 10.1038/ncomms14865 |
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24 | |
Yu, Tao1,2,9; Gan, Shucheng1,2,9; Zhu, Qingchen1,2,9; Dai, Dongfang3; Li, Ni1,2,4; Wang, Hui5; Chen, Xiaosong5; Hou, Dan1,2; Wang, Yan1,2; Pan, Qiang1,2,4; Xu, Jing1,2; Zhang, Xingli1,2; Liu, Junli1,2; Pei, Siyu1,2; Peng, Chao6; Wu, Ping6; Romano, Simona7; Mao, Chaoming3; Huang, Mingzhu8; Zhu, Xiaodong8; Shen, Kunwei; Qin, Jun1,2,4; Xiao, Yichuan1,2 | |
2019-09-25 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; Italy |
英文摘要 | Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 polarization. Mechanistically, Trim24, a CBP-associated E3 ligase, promotes Stat6 acetylation by catalyzing CBP ubiquitination at Lys119 to facilitate the recruitment of CBP to Stat6. Loss of Trim24 inhibits Stat6 acetylation and thus promotes M2 polarization in both mouse and human macrophages, potentially compromising antitumor immune responses. By contrast, Stat6 mediates the suppression of TRIM24 expression in M2 macrophages to contribute to the induction of an immunosuppressive tumor niche. Taken together, our findings establish Stat6 acetylation as an essential negative regulatory mechanism that curtails macrophage M2 polarization. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000487585600014 |
WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; TRANSCRIPTION FACTOR ; FAMILY PROTEINS ; DNA-BINDING ; ACETYLATION ; RECEPTOR ; ACTIVATION ; EXPRESSION ; RECOGNITION ; IMMUNITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203263 |
专题 | 资源环境科学 |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 3.Jiangsu Univ, Affiliated Hosp, Inst Oncol, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China; 4.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Comprehens Breast Hlth Ctr, Shanghai 200025, Peoples R China; 7.Shanghai Zhangjiang Lab, Natl Facil Prot Sci, Shanghai 201210, Peoples R China; 8.Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy; 9.Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Tao,Gan, Shucheng,Zhu, Qingchen,et al. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Yu, Tao.,Gan, Shucheng.,Zhu, Qingchen.,Dai, Dongfang.,Li, Ni.,...&Xiao, Yichuan.(2019).Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.NATURE COMMUNICATIONS,10. |
MLA | Yu, Tao,et al."Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24".NATURE COMMUNICATIONS 10(2019). |
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