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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum 期刊论文
SCIENCE, 2019, 366 (6464) : 454-+
作者:  Haldipur, Parthiv;  Aldinger, Kimberly A.;  Bernardo, Silvia;  Deng, Mei;  Timms, Andrew E.;  Overman, Lynne M.;  Winter, Conrad;  Lisgo, Steven N.;  Razavi, Ferechte;  Silvestri, Evelina;  Manganaro, Lucia;  Adle-Biasette, Homa;  Guilmiot, Fabien;  Russo, Rosa;  Kidron, Debora;  Hof, Patrick R.;  Gerrelli, Dianne;  Lindsay, Susan J.;  Dobyns, William B.;  Glass, Ian A.;  Alexandre, Paula;  Millen, Kathleen J.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes 期刊论文
NATURE, 2019, 571 (7763) : 72-+
作者:  Johnson, Eachan O.;  LaVerriere, Emily;  Office, Emma;  Stanley, Mary;  Meyer, Elisabeth;  Kawate, Tomohiko;  Gomez, James E.;  Audette, Rebecca E.;  Bandyopadhyay, Nirmalya;  Betancourt, Natalia;  Delano, Kayla;  Da Silva, Israel;  Davis, Joshua;  Gallo, Christina;  Gardner, Michelle;  Golas, Aaron J.;  Guinn, Kristine M.;  Kennedy, Sofia;  Korn, Rebecca;  McConnell, Jennifer A.;  Moss, Caitlin E.;  Murphy, Kenan C.;  Nietupski, Raymond M.;  Papavinasasundaram, Kadamba G.;  Pinkham, Jessica T.;  Pino, Paula A.;  Proulx, Megan K.;  Ruecker, Nadine;  Song, Naomi;  Thompson, Matthew;  Trujillo, Carolina;  Wakabayashi, Shoko;  Wallach, Joshua B.;  Watson, Christopher;  Ioerger, Thomas R.;  Lander, Eric S.;  Hubbard, Brian K.;  Serrano-Wu, Michael H.;  Ehrt, Sabine;  Fitzgerald, Michael;  Rubin, Eric J.;  Sassetti, Christopher M.;  Schnappinger, Dirk;  Hung, Deborah T.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
A planetesimal orbiting within the debris disc around a white dwarf star 期刊论文
SCIENCE, 2019, 364 (6435) : 66-+
作者:  Manser, Christopher J.;  Gansicke, Boris T.;  Eggl, Siegfried;  Hollands, Mark;  Izquierdo, Paula;  Koester, Detlev;  Landstreet, John D.;  Lyra, Wladimir;  Marsh, Thomas R.;  Meru, Farzana;  Mustill, Alexander J.;  Rodriguez-Gil, Pablo;  Toloza, Odette;  Veras, Dimitri;  Wilson, David J.;  Burleigh, Matthew R.;  Davies, Melvyn B.;  Farihi, Jay;  Fusillo, Nicola Gentile;  de Martino, Domitilla;  Parsons, Steven G.;  Quirrenbach, Andreas;  Raddi, Roberto;  Reffert, Sabine;  Del Santo, Melania;  Schreiber, Matthias R.;  Silvotti, Roberto;  Toonen, Silvia;  Villaver, Eva;  Wyatt, Mark;  Xu, Siyi;  Zwart, Simon Portegies
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Empowering Latina scientists 期刊论文
SCIENCE, 2019, 363 (6429) : 825-826
作者:  Bernal, Ximena E.;  Rojas, Bibiana;  Pinto-E, Maria Alejandra;  Mendoza-Henao, Angela M.;  Herrera-Montes, Adriana;  Isabel Herrera-Montes, Maria;  Caceres Franco, Andrea del Pilar;  Ceron-Souza, Ivania;  Paz, Andrea;  Vergara, Daniela;  Barragan Contreras, Leidy Alejandra;  Salazar, Camilo;  Bohorquez Alonso, Martha Lucia;  Guarnizo, Carlos E.;  Sanchez, Adriana;  Olaya-Castro, Alexandra;  Urbina-Cardona, Nicolas;  Guayasamin, Juan M.;  Uy, Floria Mora-Kepfer;  Feris, Faride Lamadrid;  Franco-Orozco, Barbara;  Munoz, Martha M.;  Patricia Rincon-Diaz, Martha;  Sanchez Herrera, Melissa;  Betancourth-Cundar, Mileidy;  Tarvin, Rebecca D.;  Marquez, Roberto;  Lopez-Aguirre, Camilo;  Ron, Santiago R.;  Ramirez, Santiago;  Paez-Vacas, Monica;  Gaitan-Espitia, Juan Diego;  Navarrete-Mendez, Maria J.;  Vianna, Juliana A.;  Varela-Jaramillo, Andrea;  Sanchez-Martinez, Paola M.;  Caminer Rodriguez, Marcel Adrian;  Garcia-Robledo, Carlos;  Kuprewicz, Erin K.;  Gomez-Bahamon, Valentina;  Chacon-Vargas, Katherine;  Trillo, Alex;  Ramirez Castaneda, Valeria;  Buenaventura, Eliana;  Carolina Monmany-Garzia, A.;  Carolina Carnaval, Ana;  Dick, Christopher W.;  Jose Andrade-Nunez, Maria;  Carvajal Castro, Juan David;  Marcela Pinto, Diana;  Camargo-Sanabria, Angela A.;  Lips, Karen R.;  Motta-Gonzalez, Diana;  Canedo, Clarissa;  Melissa Diaz, Jhandra;  Navarro-Suarez, Adriana M.;  Corredor, Karen;  Roa-Varon, Adela;  Flechas, Sandra V.;  Andres Martinez-Lanfranco, Juan;  Chiarioni Thome, Maria Tereza;  Caldwell, Michael S.;  Ballestas, Onil;  Mejia M, Carolina;  Chaverri, Gloriana;  Rossi, Alejandra;  Bonaccorso, Elisa;  Pimiento, Catalina;  Guerrero, Rafael F.;  Warkentin, Karen M.;  Montoya-Pachongo, Carolina;  Alvarez, Silvia J.;  Gonzalez-Duran, Gustavo;  Anganoy-Criollo, Marvin;  Martinez-Habibe, Maria Cristina;  Ramirez, Juan P.;  Burrowes, Patricia;  Catenazzi, Alessandro;  Riveros, Andre J.;  Targino, Mariane;  Velez, Alejandro;  Vargas, Oscar M.;  Zapata, Felipe;  Waltrick, Camilla Spengler;  Ceron, Karoline;  Segovia Salcedo, Claudia;  Silva-Velasco, Martha;  Ochoa-Herrera, Valeria;  Medina, Iliana;  Narins, Peter M.;  Alves Saccol, Suelen da Silva;  de Castro Godinho, Marcela Brasil;  Velasquez Escobar, Beatriz Eugenia;  Velasco, Julian A.;  Lomascolo, Silvia;  Hoke, Kim;  Zeidemann, Vivian;  Almeida-Santos, Patricia;  Paola Ferraro, Daiana;  Araujo-Vieira, Katyuscia;  da Rocha, Sabine Borges;  Torres, Maria Fernanda;  Daniel Cadena, Carlos;  Collevatti, Rosane Garcia;  Vasconcellos, Mariana Mira;  Recart, Wilnelia;  Mitchell Aide, T.;  Bacon, Christine;  Jeckel, Adriana Moriguchi;  Diele-Viegas, Luisa Maria;  Calijorne Lourenco, Ana Carolina;  Santos, Danusy Lopes;  Rieder Cholak, Luiza;  Mendes, Roberta Graboski;  Silva, Fernanda Magalhaes;  Guedes, Thais;  Lopez-Perilla, Yeny R.;  Fusinatto, Luciana Ardenghi;  Terra, Juliana de Souza;  Rodriguez Brenes, Sofia;  Narvaez, Andrea E.;  Zina, Juliana;  Calderon-Espinosa, Martha L.;  Pardo-Diaz, Carolina;  Abadie, Michelle;  Maldonado-Chaparro, Adriana;  Cespedes Arias, Laura N.;  Montesinos, Rachel;  Fenker, Jessica;  Brunes, Tuliana Oliveira;  Ferreira Lantyer Silva, Amanda Santiago;  Vallejos, Johana Goyes;  Costa Rodrigues, Ana Paula V.;  Friol, Natalia Rizzo;  Herrera-Alvarez, Santiago;  de Souza, Eletra;  Araujo, Olivia G. S.;  Citeli, Nathalie Q. K.;  Ruggeri, Joice;  Fierro-Calderon, Eliana;  Acevedo-Charry, Orlando;  Barato, Paola;  Campos-Cerqueira, Marconi;  Mazzini, Flavia;  Beltran, Ivan;  Alejandra Meneses-Giorgi, Maria;  Jerez, Adriana;  Clavijo, Andrea P.;  Neira Jimenez, Carolina;  Dantas, Gisele P. M.;  Nascimento, Luciana Barreto;  Caballero, Susana J.;  Henao Sepulveda, A. Carolina;  Wolff, Marta;  Barnabe, Paula Cristina;  Quinones-Lebron, Shakira G.;  Bressan, Raissa Fries;  Gomez-Montoya, Nataly;  Gomez, Camila;  Colon-Pineiro, Zuania;  Esquivel Dobles, Carolina;  Bloch, Natasha;  Stynoski, Jennifer L.;  Arango, Daniel;  Marisol Gonzalez, Tania;  Luque Moreno, Francisco;  Taylor, Ryan;  Lawrence, J. P.;  Briscoe, Adriana Darielle Mejia;  Ortiz-Barrientos, Daniel;  Elena Salerno, Patricia;  Restrepo, Silvia;  Pasukonis, Andrius;  Damasceno, Roberta Pacheco;  Cecilia Dalton, Maria;  Proehl, Heike;  Valdez-Ward, Evelyn;  Andrea Rodriguez, Sabrina;  Marquez Garcia, Marcela;  Bianca Bonaparte, Eugenia;  Molina Escobar, Jorge Alberto;  Brown, Jason L.;  Yeager, Justin;  Kikuchi, David;  Ringler, Max;  Duran, Linda Hernandez;  Schulte, Lisa M.;  Vaira, Marcos;  Pereyra, Laura;  Astudillo Bravo, Diana;  Jose Salica, Maria;  Varga, Sandra;  Eguren, Antonieta;  Grattarola, Florencia;  Bernal, Moises A.;  Soledad Gaston, Maria;  Ortega Chinchilla, Jesus Eduardo;  Burdfield-Steel, Emily;  Valencia, Lina M.;  Ringler, Eva;  Rada, Marco;  Melendez-Ackerman, Elvia;  Botero, Carlos A.;  Estrada-Villegas, Sergio;  Orizaola, German;  Pinto, Brendan J.;  Gonzalez-Bellido, Paloma;  Hunter, Kimberly L.;  Rueda Solano, Luis Alberto;  Gordon, Swanne;  Guerra, Monica A.;  Jose Albo, Maria;  Vega-Frutis, Rocio;  Blundo, Cecilia;  Castaneda-Gomez, Laura;  Donnelly, Maureen A.;  Escobar, Betsabe D. Castro;  Isabel Moreno, Maria;  Crawford, Andrew J.;  Jiggins, Chris D.;  Roessler, Daniela C.;  Bravo Valencia, Laura;  Sarmiento, Carolina;  Munoz, Karen A.;  Galeano, Sandra P.;  del Rosario Castaneda, Maria;  Caro Cardenas, Cindy Jeanet;  Zalamea, Paul-Camilo;  Arias, Monica;  Zank, Caroline;  Suarez-Mayorga, Angela M.;  Colombo, Patrick;  Cuervo, Andres M.;  Coriolano, Iara Reinaldo;  de Melo, Lilian Sayuri Ouchi;  Buitrago Cardona, Alexandra;  Elias, Marianne;  Gonzalez, Mabel;  Maria Aldana, Ana;  Gubert, Carolina;  Luis Parra, Juan;  Contador, Tamara;  Coelho, Lorena;  Trillo, Mariana;  Bordin, Kauane;  Zulian, Viviane;  Moreno Arias, Rafael;  Loretto, Matthias-Claudio;  Alejandra Medina, Claudia;  Lyra, Mariana L.;  Pulido-Santacruz, Paola;  Rosser, Neil;  Waldron, Talia;  Moreno Duran, Carmen Helena;  Pizano, Camila;  Hoedl, Walter;  Fratani, Jessica;  Duport Bru, Ana Sofia;  Grosso, Jimena;  Vera Candioti, Florencia;  Adarve Rengifo, Isabel
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity (vol 483, pg 603, 2012) 期刊论文
NATURE, 2019, 565 (7738) : E5-E6
作者:  Barretina, Jordi;  Caponigro, Giordano;  Stransky, Nicolas;  Venkatesan, Kavitha;  Margolin, Adam A.;  Kim, Sungjoon;  Wilson, Christopher J.;  Lehar, Joseph;  Kryukov, Gregory V.;  Sonkin, Dmitriy;  Reddy, Anupama;  Liu, Manway;  Murray, Lauren;  Berger, Michael F.;  Monahan, John E.;  Morais, Paula;  Meltzer, Jodi;  Korejwa, Adam;  Jane-Valbuena, Judit;  Mapa, Felipa A.;  Thibault, Joseph;  Bric-Furlong, Eva;  Raman, Pichai;  Shipway, Aaron;  Engels, Ingo H.;  Cheng, Jill;  Yu, Guoying K.;  Yu, Jianjun;  Aspesi, Peter, Jr.;  de Silva, Melanie;  Jagtap, Kalpana;  Jones, Michael D.;  Wang, Li;  Hatton, Charles;  Palescandolo, Emanuele;  Gupta, Supriya;  Mahan, Scott;  Sougnez, Carrie;  Onofrio, Robert C.;  Liefeld, Ted;  MacConaill, Laura;  Winckler, Wendy;  Reich, Michael;  Li, Nanxin;  Mesirov, Jill P.;  Gabriel, Stacey B.;  Getz, Gad;  Ardlie, Kristin;  Chan, Vivien;  Myer, Vic E.;  Weber, Barbara L.;  Porter, Jeff;  Warmuth, Markus;  Finan, Peter;  Harris, Jennifer L.;  Meyerson, Matthew;  Golub, Todd R.;  Morrissey, Michael P.;  Sellers, William R.;  Schlegel, Robert;  Garraway, Levi A.
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/27
GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (45) : 22505-22511
作者:  Zhirui Zeng;  Xiao-Lei Liu;  Kristen R. Farley;  Jeremy H. Wei;  William W. Metcalf;  Roger E. Summons;  and Paula V. Welander
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
GDGT  radical SAM  paleotemperature proxies  
Protect NIH's DNA advisory committee 期刊论文
SCIENCE, 2018, 362 (6413) : 409-410
作者:  Adelman, Zach N.;  Albritton, Lorraine M.;  Boris-Lawrie, Kathleen;  Buchmeier, Michael J.;  Cannon, Paula;  Cho, Mildred;  DiGiusto, David;  Donahue, J. Kevin;  Federoff, Howard J.;  Hammarskjold, Marie-Louise;  Hardison, Angelica D.;  Hearing, Patrick;  Lee, Benhur;  Lee, Dean Anthony;  Porteus, Matthew H.;  Ross, Lainie Friedman;  Ross, Susan R.;  Wooley, Dawn P.;  Zoloth, Laurie
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice 期刊论文
SCIENCE, 2017, 357 (6352) : 717-+
作者:  Zhao, Fei;  Franco, Heather L.;  Rodriguez, Karina F.;  Brown, Paula R.;  Tsai, Ming-Jer;  Tsai, Sophia Y.;  Yao, Humphrey H. -C.
收藏  |  浏览/下载:3/0  |  提交时间:2019/11/27