Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1073/pnas.1909306116 |
GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean | |
Zhirui Zeng; Xiao-Lei Liu; Kristen R. Farley; Jeremy H. Wei; William W. Metcalf; Roger E. Summons; and Paula V. Welander | |
2019 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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出版年 | 2019 |
卷号 | 116期号:45页码:22505-22511 |
英文摘要 | AbstractGlycerol dibiphytanyl glycerol tetraethers (GDGTs) are distinctive archaeal membrane-spanning lipids with up to eight cyclopentane rings and/or one cyclohexane ring. The number of rings added to the GDGT core structure can vary as a function of environmental conditions, such as changes in growth temperature. This physiological response enables cyclic GDGTs preserved in sediments to be employed as proxies for reconstructing past global and regional temperatures and to provide fundamental insights into ancient climate variability. Yet, confidence in GDGT-based paleotemperature proxies is hindered by uncertainty concerning the archaeal communities contributing to GDGT pools in modern environments and ambiguity in the environmental and physiological factors that affect GDGT cyclization in extant archaea. To properly constrain these uncertainties, a comprehensive understanding of GDGT biosynthesis is required. Here, we identify 2 GDGT ring synthases, GrsA and GrsB, essential for GDGT ring formation in Sulfolobus acidocaldarius. Both proteins are radical S-adenosylmethionine proteins, indicating that GDGT cyclization occurs through a free radical mechanism. In addition, we demonstrate that GrsA introduces rings specifically at the C-7 position of the core GDGT lipid, while GrsB cyclizes at the C-3 position, suggesting that cyclization patterns are differentially controlled by 2 separate enzymes and potentially influenced by distinct environmental factors. Finally, phylogenetic analyses of the Grs proteins reveal that marine Thaumarchaeota, and not Euryarchaeota, are the dominant source of cyclized GDGTs in open ocean settings, addressing a major source of uncertainty in GDGT-based paleotemperature proxy applications. |
英文关键词 | GDGT radical SAM paleotemperature proxies |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/205201 |
专题 | 地球科学 资源环境科学 气候变化 |
推荐引用方式 GB/T 7714 | Zhirui Zeng,Xiao-Lei Liu,Kristen R. Farley,et al. GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(45):22505-22511. |
APA | Zhirui Zeng.,Xiao-Lei Liu.,Kristen R. Farley.,Jeremy H. Wei.,William W. Metcalf.,...&and Paula V. Welander.(2019).GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(45),22505-22511. |
MLA | Zhirui Zeng,et al."GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.45(2019):22505-22511. |
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