Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax7526 |
Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum | |
Haldipur, Parthiv1; Aldinger, Kimberly A.1; Bernardo, Silvia2,3; Deng, Mei4; Timms, Andrew E.1; Overman, Lynne M.5; Winter, Conrad1; Lisgo, Steven N.5; Razavi, Ferechte6; Silvestri, Evelina7; Manganaro, Lucia2,3; Adle-Biasette, Homa8,9; Guilmiot, Fabien10; Russo, Rosa11; Kidron, Debora12,13; Hof, Patrick R.14,15; Gerrelli, Dianne16; Lindsay, Susan J.5; Dobyns, William B.1,4; Glass, Ian A.1,4; Alexandre, Paula16; Millen, Kathleen J.1,4 | |
2019-10-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6464页码:454-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Italy; England; France; Israel |
英文摘要 | We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493177900041 |
WOS关键词 | DANDY-WALKER MALFORMATION ; SONIC HEDGEHOG ; CORTICAL LAYERS ; RHOMBIC LIP ; RADIAL GLIA ; CORTEX ; CELLS ; EXPRESSION ; EVOLUTION ; GROWTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202637 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA 98101 USA; 2.Sapienza Univ Rome, Dept Expt Med, Rome, Italy; 3.Sapienza Univ Rome, Dept Radiol Sci, Rome, Italy; 4.Univ Washington, Dept Pediat, Seattle, WA 98195 USA; 5.Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne, Tyne & Wear, England; 6.Hop Necker Enfants Malad, AP HP, Paris, France; 7.San Camillo Forlanini Hosp, Surg Pathol Unit, Rome, Italy; 8.Hop Lariboisiere, AP HP, Dept Pathol, Paris, France; 9.Univ Paris, INSERM, NeuroDiderot, Paris, France; 10.Hop Robert Debre, INSERM, UMR 1141, Paris, France; 11.Univ Med Hosp, Dept Pathol, Salerno, Italy; 12.Meir Med Ctr, Dept Pathol, Kefar Sava, Israel; 13.Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel; 14.Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA; 15.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA; 16.UCL, Great Ormond St Inst Child Hlth, London, England |
推荐引用方式 GB/T 7714 | Haldipur, Parthiv,Aldinger, Kimberly A.,Bernardo, Silvia,et al. Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum[J]. SCIENCE,2019,366(6464):454-+. |
APA | Haldipur, Parthiv.,Aldinger, Kimberly A..,Bernardo, Silvia.,Deng, Mei.,Timms, Andrew E..,...&Millen, Kathleen J..(2019).Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum.SCIENCE,366(6464),454-+. |
MLA | Haldipur, Parthiv,et al."Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum".SCIENCE 366.6464(2019):454-+. |
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