Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aai9136 |
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice | |
Zhao, Fei1; Franco, Heather L.1; Rodriguez, Karina F.1; Brown, Paula R.1; Tsai, Ming-Jer2; Tsai, Sophia Y.2; Yao, Humphrey H. -C.1 | |
2017-08-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6352页码:717-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407793600042 |
WOS关键词 | MESENCHYMAL EPITHELIAL INTERACTIONS ; WOLFFIAN DUCT DEVELOPMENT ; PROSTATE-CANCER ; GROWTH-FACTOR ; EXPRESSION ; DIFFERENTIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196697 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIEHS, Reprod Dev Biol Grp, POB 12233, Res Triangle Pk, NC 27709 USA; 2.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Zhao, Fei,Franco, Heather L.,Rodriguez, Karina F.,et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice[J]. SCIENCE,2017,357(6352):717-+. |
APA | Zhao, Fei.,Franco, Heather L..,Rodriguez, Karina F..,Brown, Paula R..,Tsai, Ming-Jer.,...&Yao, Humphrey H. -C..(2017).Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.SCIENCE,357(6352),717-+. |
MLA | Zhao, Fei,et al."Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice".SCIENCE 357.6352(2017):717-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论