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Agricultural breadbaskets shift poleward given adaptive farmer behavior under climate change 期刊论文
Global Change Biology, 2021
作者:  James A. Franke;  Christoph Mü;  ller;  Sara Minoli;  Joshua Elliott;  Christian Folberth;  Charles Gardner;  Tobias Hank;  Roberto Cesar Izaurralde;  Jonas Jä;  germeyr;  Curtis D. Jones;  Wenfeng Liu;  Stefan Olin;  Thomas A.M. Pugh;  Alex C. Ruane;  Haynes Stephens;  Florian Zabel;  Elisabeth J. Moyer
收藏  |  浏览/下载：14/0  |  提交时间：2021/10/22
Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain 期刊论文
Science, 2021
作者:  Ana C. Delgado;  Angel R. Maldonado-Soto;  Violeta Silva-Vargas;  Dogukan Mizrak;  Thomas von Känel;  Kelly R. Tan;  Alex Paul;  Aviv Madar;  Henar Cuervo;  Jan Kitajewski;  Chyuan-Sheng Lin;  Fiona Doetsch
收藏  |  浏览/下载：10/0  |  提交时间：2021/06/15
Disturbance type and species life history predict mammal responses to humans 期刊论文
Global Change Biology, 2021
作者:  Justin P. Suraci;  Kaitlyn M. Gaynor;  Maximilian L. Allen;  Peter Alexander;  Justin S. Brashares;  Sara Cendejas-Zarelli;  Kevin Crooks;  L. Mark Elbroch;  Tavis Forrester;  Austin M. Green;  Jeffrey Haight;  Nyeema C. Harris;  Mark Hebblewhite;  Forest Isbell;  Barbara Johnston;  Roland Kays;  Patrick E. Lendrum;  Jesse S. Lewis;  Alex McInturff;  William McShea;  Thomas W. Murphy;  Meredith S. Palmer;  Arielle Parsons;  Mitchell A. Parsons;  Mary E. Pendergast;  Charles Pekins;  Laura R. Prugh;  Kimberly A. Sager-Fradkin;  Stephanie Schuttler;  Ç;  ağ;  an H. Ş;  ekercioğ;  lu;  Brenda Shepherd;  Laura Whipple;  Jesse Whittington;  George Wittemyer;  Christopher C. Wilmers
收藏  |  浏览/下载：20/0  |  提交时间：2021/06/07
Large potential for crop production adaptation depends on available future varieties 期刊论文
Global Change Biology, 2021
作者:  Florian Zabel;  Christoph Mü;  ller;  Joshua Elliott;  Sara Minoli;  Jonas Jä;  germeyr;  Julia M. Schneider;  James A. Franke;  Elisabeth Moyer;  Marie Dury;  Louis Francois;  Christian Folberth;  Wenfeng Liu;  Thomas A.M. Pugh;  Stefan Olin;  Sam S. Rabin;  Wolfram Mauser;  Tobias Hank;  Alex C. Ruane;  Senthold Asseng
收藏  |  浏览/下载：17/0  |  提交时间：2021/06/07
Mapping out a future for ungulate migrations 期刊论文
Science, 2021
作者:  Matthew J. Kauffman;  Francesca Cagnacci;  Simon Chamaillé-Jammes;  Mark Hebblewhite;  J. Grant C. Hopcraft;  Jerod A. Merkle;  Thomas Mueller;  Atle Mysterud;  Wibke Peters;  Christiane Roettger;  Alethea Steingisser;  James E. Meacham;  Kasahun Abera;  Jan Adamczewski;  Ellen O. Aikens;  Hattie Bartlam-Brooks;  Emily Bennitt;  Joel Berger;  Charlotte Boyd;  Steeve D. Côté;  Lucie Debeffe;  Andrea S. Dekrout;  Nandintsetseg Dejid;  Emiliano Donadio;  Luthando Dziba;  William F. Fagan;  Claude Fischer;  Stefano Focardi;  John M. Fryxell;  Richard W. S. Fynn;  Chris Geremia;  Benito A. González;  Anne Gunn;  Elie Gurarie;  Marco Heurich;  Jodi Hilty;  Mark Hurley;  Aran Johnson;  Kyle Joly;  Petra Kaczensky;  Corinne J. Kendall;  Pavel Kochkarev;  Leonid Kolpaschikov;  Rafał Kowalczyk;  Frank van Langevelde;  Binbin V. Li;  Alex L. Lobora;  Anne Loison;  Tinaapi H. Madiri;  David Mallon;  Pascal Marchand;  Rodrigo A. Medellin;  Erling Meisingset;  Evelyn Merrill;  Arthur D. Middleton;  Kevin L. Monteith;  Malik Morjan;  Thomas A. Morrison;  Steffen Mumme;  Robin Naidoo;  Andres Novaro;  Joseph O. Ogutu;  Kirk A. Olson;  Alfred Oteng-Yeboah;  Ramiro J. A. Ovejero;  Norman Owen-Smith;  Antti Paasivaara;  Craig Packer;  Danila Panchenko;  Luca Pedrotti;  Andrew J. Plumptre;  Christer M. Rolandsen;  Sonia Said;  Albert Salemgareyev;  Aleksandr Savchenko;  Piotr Savchenko;  Hall Sawyer;  Moses Selebatso;  Matthew Skroch;  Erling Solberg;  Jared A. Stabach;  Olav Strand;  Michael J. Suitor;  Yasuyuki Tachiki;  Anne Trainor;  Arnold Tshipa;  Munir Z. Virani;  Carly Vynne;  Stephanie Ward;  George Wittemyer;  Wenjing Xu;  Steffen Zuther
收藏  |  浏览/下载：28/0  |  提交时间：2021/05/14
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 期刊论文
Science, 2020
作者:  Thomas W. Linsky;  Renan Vergara;  Nuria Codina;  Jorgen W. Nelson;  Matthew J. Walker;  Wen Su;  Christopher O. Barnes;  Tien-Ying Hsiang;  Katharina Esser-Nobis;  Kevin Yu;  Z. Beau Reneer;  Yixuan J. Hou;  Tanu Priya;  Masaya Mitsumoto;  Avery Pong;  Uland Y. Lau;  Marsha L. Mason;  Jerry Chen;  Alex Chen;  Tania Berrocal;  Hong Peng;  Nicole S. Clairmont;  Javier Castellanos;  Yu-Ru Lin;  Anna Josephson-Day;  Ralph S. Baric;  Deborah H. Fuller;  Carl D. Walkey;  Ted M. Ross;  Ryan Swanson;  Pamela J. Bjorkman;  Michael Gale;  Luis M. Blancas-Mejia;  Hui-Ling Yen;  Daniel-Adriano Silva
收藏  |  浏览/下载：11/0  |  提交时间：2020/12/07
Extensive heterogeneity in somatic mutation and selection in the human bladder 期刊论文
Science, 2020
作者:  Andrew R. J. Lawson;  Federico Abascal;  Tim H. H. Coorens;  Yvette Hooks;  Laura O’Neill;  Calli Latimer;  Keiran Raine;  Mathijs A. Sanders;  Anne Y. Warren;  Krishnaa T. A. Mahbubani;  Bethany Bareham;  Timothy M. Butler;  Luke M. R. Harvey;  Alex Cagan;  Andrew Menzies;  Luiza Moore;  Alexandra J. Colquhoun;  William Turner;  Benjamin Thomas;  Vincent Gnanapragasam;  Nicholas Williams;  Doris M. Rassl;  Harald Vöhringer;  Sonia Zumalave;  Jyoti Nangalia;  José M. C. Tubío;  Moritz Gerstung;  Kourosh Saeb-Parsy;  Michael R. Stratton;  Peter J. Campbell;  Thomas J. Mitchell;  Iñigo Martincorena
收藏  |  浏览/下载：20/0  |  提交时间：2020/10/12
Modelling climate change impacts on maize yields under low nitrogen input conditions in sub‐Saharan Africa 期刊论文
Global Change Biology, 2020
作者:  Gatien N. Falconnier;  Marc Corbeels;  Kenneth J. Boote;  Franç;  ois Affholder;  Myriam Adam;  Dilys S. MacCarthy;  Alex C. Ruane;  Claas Nendel;  Anthony M. Whitbread;  É;  ric Justes;  Lajpat R. Ahuja;  Folorunso M. Akinseye;  Isaac N. Alou;  Kokou A. Amouzou;  Saseendran S. Anapalli;  Christian Baron;  Bruno Basso;  Fré;  dé;  ric Baudron;  Patrick Bertuzzi;  Andrew J. Challinor;  Yi Chen;  Delphine Deryng;  Maha L. Elsayed;  Babacar Faye;  Thomas Gaiser;  Marcelo Galdos;  Sebastian Gayler;  Edward Gerardeaux;  Michel Giner;  Brian Grant;  Gerrit Hoogenboom;  Esther S. Ibrahim;  Bahareh Kamali;  Kurt Christian Kersebaum;  Soo‐;  Hyung Kim;  Michael van der Laan;  Louise Leroux;  Jon I. Lizaso;  Bernardo Maestrini;  Elizabeth A. Meier;  Fasil Mequanint;  Alain Ndoli;  Cheryl H. Porter;  Eckart Priesack;  Dominique Ripoche;  Tesfaye S. Sida;  Upendra Singh;  Ward N. Smith;  Amit Srivastava;  Sumit Sinha;  Fulu Tao;  Peter J. Thorburn;  Dennis Timlin;  Bouba Traore;  Tracy Twine;  Heidi Webber
收藏  |  浏览/下载：12/0  |  提交时间：2020/08/25
Pervasive ice sheet mass loss reflects competing ocean and atmosphere processes 期刊论文
Science, 2020
作者:  Ben Smith;  Helen A. Fricker;  Alex S. Gardner;  Brooke Medley;  Johan Nilsson;  Fernando S. Paolo;  Nicholas Holschuh;  Susheel Adusumilli;  Kelly Brunt;  Bea Csatho;  Kaitlin Harbeck;  Thorsten Markus;  Thomas Neumann;  Matthew R. Siegfried;  H. Jay Zwally
收藏  |  浏览/下载：13/0  |  提交时间：2020/06/16
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.