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Measurements of the diversity of shape and mixing state for ambient black carbon particles 期刊论文
Geophysical Research Letters, 2021
作者:  Kang Hu;  Dantong Liu;  Ping Tian;  Yangzhou Wu;  Zhaoze Deng;  Yunfei Wu;  Delong Zhao;  Ruijie Li;  Jiujiang Sheng;  Mengyu Huang;  Deping Ding;  Weijun Li;  Yuanyuan Wang;  Yu Wu
收藏  |  浏览/下载：15/0  |  提交时间：2021/08/30
Chemical components and source identification of PM2.5 in non-heating season in Beijing: The influences of biomass burning and dust 期刊论文
Atmospheric Research, 2020
作者:  Yanqin Ren, Jie Wei, Zhenhai Wu, Yuanyuan Ji, ... Hong Li
收藏  |  浏览/下载：11/0  |  提交时间：2020/12/28
Measurement report: Amino acids in fine and coarse atmospheric aerosol: concentrations, compositions, sources and possible bacterial degradation state 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ren-guo Zhu, Hua-Yun Xiao, Li Luo, Hongwei Xiao, Zequn Wen, Yuwen Zhu, Xiaozheng Fang, Yuanyuan Pan, and Zhenping Chen
收藏  |  浏览/下载：12/0  |  提交时间：2020/08/09
Exchange Dynamics of Typical Emerging and Legacy Persistent Organic Pollutants at the Air-Water Interface Over a Strongly Human-Influenced Large River Estuary 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Guo, Tianfeng;  Li, Yuanyuan;  Lin, Tian;  Wu, Zilan;  Jiang, Yuqing;  Guo, Zhigang
收藏  |  浏览/下载：6/0  |  提交时间：2020/08/18
BDE-209  PCB  air-water gas exchange  transport pathway  source-sink fate  
Tracing the evolution of morphology and mixing state of sootparticles along with the movement of an Asian dust storm 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Liang Xu, Satoshi Fukushima, Sophie Sobanska, Kotaro Murata, Ayumi Naganuma, Lei Liu, Yuanyuan Wang, Hongya Niu, Zongbo Shi, Tomoko Kojima, Daizhou Zhang, and Weijun Li
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/06
Significant production of ClNO2 and possible source of Cl-2 from N2O5 uptake at a suburban site in eastern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 6147-6158
作者:  Xia, Men;  Peng, Xiang;  Wang, Weihao;  Yu, Chuan;  Sun, Peng;  Li, Yuanyuan;  Liu, Yuliang;  Xu, Zhengning;  Wang, Zhe;  Xu, Zheng;  Nie, Wei;  Ding, Aijun;  Wang, Tao
收藏  |  浏览/下载：14/0  |  提交时间：2020/06/01
Comparison of forest above‐ground biomass from dynamic global vegetation models with spatially explicit remotely sensed observation‐based estimates 期刊论文
Global Change Biology, 2020
作者:  Hui Yang;  Philippe Ciais;  Maurizio Santoro;  Yuanyuan Huang;  Wei Li;  Yilong Wang;  Ana Bastos;  Daniel Goll;  Almut Arneth;  Peter Anthoni;  Vivek K. Arora;  Pierre Friedlingstein;  Vanessa Harverd;  Emilie Joetzjer;  Markus Kautz;  Sebastian Lienert;  Julia E. M. S. Nabel;  Michael O'Sullivan;  Stephen Sitch;  Nicolas Vuichard;  Andy Wiltshire;  Dan Zhu
收藏  |  浏览/下载：12/0  |  提交时间：2020/05/20
Impact of in-cloud aqueous processes on the chemical compositions and morphology of individual atmospheric aerosols 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Yuzhen Fu, Qinhao Lin, Guohua Zhang, Yuxiang Yang, Yiping Yang, Xiufeng Lian, Long Peng, Feng Jiang, Xinhui Bi, Lei Li, Yuanyuan Wang, Duohong Chen, Jie Ou, Xinming Wang, Ping'an Peng, Jianxi Zhu, and Guoying Sheng
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Reply to Comment by Peng and Bi on "Retrieval of Atmospheric Fine Particulate Density Based on Merging Particle Size Distribution Measurements: Multi-instrument Observation and Quality Control at Shouxian" 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (2)
作者:  Li, Zhengqiang;  Wei, Yuanyuan;  Zhang, Ying
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/02