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The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia 期刊论文
Science, 2021
作者:  Zengzhang Zheng;  Wanyan Deng;  Yang Bai;  Rui Miao;  Shenglin Mei;  Zhibin Zhang;  Youdong Pan;  Yi Wang;  Rui Min;  Fan Deng;  Zeyu Wu;  Wu Li;  Pengcheng Chen;  Tianchi Ma;  Xiwen Lou;  Judy Lieberman;  Xing Liu
收藏  |  浏览/下载:9/0  |  提交时间:2021/07/27
Application potential of satellite thermal anomaly products in updating industrial emission inventory of China 期刊论文
Geophysical Research Letters, 2021
作者:  Rong Li;  Minghui Tao;  Meigen Zhang;  Liangfu Chen;  Lili Wang;  Yi Wang;  Xinjie He;  Lifei Wei;  Xin Mei;  Jun Wang
收藏  |  浏览/下载:7/0  |  提交时间:2021/04/20
Direct observation of sulfate explosive growth in wet plumes emitted from typical coal‐fired stationary sources 期刊论文
Geophysical Research Letters, 2021
作者:  Xiang Ding;  Qing Li;  Di Wu;  Xiaoyan Wang;  Mei Li;  Tao Wang;  Lin Wang;  Jianmin Chen
收藏  |  浏览/下载:10/0  |  提交时间:2021/03/17
Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
Characteristics and source apportionment of ambient single particles in Tianjin, China: The close association between oxalic acid and biomass burning 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Xu, Jiao;  Tian, Yingze;  Cheng, Chunlei;  Wang, Chuang;  Lin, Qiuju;  Li, Mei;  Wang, Xiaofei;  Shi, Guoliang
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Single particle  Oxalic acid  Biomass burning  Source contribution  PMF  SPAMS  
Sweet spots are in the food system: Structural adjustments to co-control regional pollutants and national GHG emissions in China 期刊论文
ECOLOGICAL ECONOMICS, 2020, 171
作者:  Liu, Li-Jing;  Liang, Qiao-Mei;  Creutzig, Felix;  Ward, Hauke;  Zhang, Kun
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/02
Greenhouse gas  Pollutant  Multi-regional input-output  China  Co-benefits  Elasticity analysis  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Obesogenic environmental factors of adult obesity in China: a nationally representative cross-sectional study 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (4)
作者:  Zhang, Xiao;  Zhang, Mei;  Zhao, Zhenping;  Huang, Zhengjing;  Deng, Qian;  Li, Yichong;  Pan, An;  Li, Chun;  Chen, Zhihua;  Zhou, Maigeng;  Yu, Chao;  Stein, Alfred;  Jia, Peng;  Wang, Limin
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
obesity  adult  physical environment  built environment  food environment  socioeconomic environment  
Ground-Based Cloud Classification Using Task-Based Graph Convolutional Network 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Liu, Shuang;  Li, Mei;  Zhang, Zhong;  Cao, Xiaozhong;  Durrani, Tariq S.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02