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The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia 期刊论文
Science, 2021
作者:  Zengzhang Zheng;  Wanyan Deng;  Yang Bai;  Rui Miao;  Shenglin Mei;  Zhibin Zhang;  Youdong Pan;  Yi Wang;  Rui Min;  Fan Deng;  Zeyu Wu;  Wu Li;  Pengcheng Chen;  Tianchi Ma;  Xiwen Lou;  Judy Lieberman;  Xing Liu
收藏  |  浏览/下载：10/0  |  提交时间：2021/07/27
3D genomics across the tree of life reveals condensin II as a determinant of architecture type 期刊论文
Science, 2021
作者:  Claire Hoencamp;  Olga Dudchenko;  Ahmed M. O. Elbatsh;  Sumitabha Brahmachari;  Jonne A. Raaijmakers;  Tom van Schaik;  Ángela Sedeño Cacciatore;  Vinícius G. Contessoto;  Roy G. H. P. van Heesbeen;  Bram van den Broek;  Aditya N. Mhaskar;  Hans Teunissen;  Brian Glenn St Hilaire;  David Weisz;  Arina D. Omer;  Melanie Pham;  Zane Colaric;  Zhenzhen Yang;  Suhas S. P. Rao;  Namita Mitra;  Christopher Lui;  Weijie Yao;  Ruqayya Khan;  Leonid L. Moroz;  Andrea Kohn;  Judy St. Leger;  Alexandria Mena;  Karen Holcroft;  Maria Cristina Gambetta;  Fabian Lim;  Emma Farley;  Nils Stein;  Alexander Haddad;  Daniel Chauss;  Ayse Sena Mutlu;  Meng C. Wang;  Neil D. Young;  Evin Hildebrandt;  Hans H. Cheng;  Christopher J. Knight;  Theresa L. U. Burnham;  Kevin A. Hovel;  Andrew J. Beel;  Pierre-Jean Mattei;  Roger D. Kornberg;  Wesley C. Warren;  Gregory Cary;  José Luis Gómez-Skarmeta;  Veronica Hinman;  Kerstin Lindblad-Toh;  Federica Di Palma;  Kazuhiro Maeshima;  Asha S. Multani;  Sen Pathak;  Liesl Nel-Themaat;  Richard R. Behringer;  Parwinder Kaur;  René H. Medema;  Bas van Steensel;  Elzo de Wit;  José N. Onuchic;  Michele Di Pierro;  Erez Lieberman Aiden;  Benjamin D. Rowland
收藏  |  浏览/下载：12/0  |  提交时间：2021/06/07
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).