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Limited and localized magmatism in the Central Atlantic Magmatic Province 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Marzen, R. E.;  Shillington, D. J.;  Lizarralde, D.;  Knapp, J. H.;  Heffner, D. M.;  Davis, J. K.;  Harder, S. H.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/09
Disturbance refugia within mosaics of forest fire, drought, and insect outbreaks 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2020, 18 (5) : 235-244
作者:  Krawchuk, Meg A.;  Meigs, Garrett W.;  Cartwright, Jennifer M.;  Coop, Jonathan D.;  Davis, Raymond;  Holz, Andres;  Kolden, Crystal;  Meddens, Arjan J. H.
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/09
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Agricultural risks from changing snowmelt 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (5) : 459-+
作者:  Qin, Yue;  Abatzoglou, John T.;  Siebert, Stefan;  Huning, Laurie S.;  AghaKouchak, Amir;  Mankin, Justin S.;  Hong, Chaopeng;  Tong, Dan;  Davis, Steven J.;  Mueller, Nathaniel D.
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
Introduced herbivores restore Late Pleistocene ecological functions 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (14) : 7871-7878
作者:  Lundgren, Erick J.;  Ramp, Daniel;  Rowan, John;  Middleton, Owen;  Schowanek, Simon D.;  Sanisidro, Oscar;  Carroll, Scott P.;  Davis, Matt;  Sandom, Christopher J.;  Svenning, Jens-Christian;  Wallach, Arian D.
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
megafauna  novel ecosystems  functional ecology  restoration ecology  invasion  
Observations of Greenhouse Gas Changes Across Summer Frontal Boundaries in the Eastern United States 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (5)
作者:  Pal, Sandip;  Davis, Kenneth J.;  Lauvaux, Thomas;  Browell, Edward, V;  Gaudet, Brian J.;  Stauffer, David R.;  Obland, Michael D.;  Choi, Yonghoon;  DiGangi, Josh P.;  Feng, Sha;  Lin, Bing;  Miles, Natasha L.;  Pauly, Rebecca M.;  Richardson, Scott J.;  Zhang, Fuqing
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/02
atmospheric boundary layer  airborne atmospheric measurements  cold front  free troposphere  greenhouse gases  midlatitude cyclone  
Climate adaptation by crop migration 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Sloat, Lindsey L.;  Davis, Steven J.;  Gerber, James S.;  Moore, Frances C.;  Ray, Deepak K.;  West, Paul C.;  Mueller, Nathaniel D.
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
Water scarcity and fish imperilment driven by beef production 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (4) : 319-328
作者:  Richter, Brian D.;  Bartak, Dominique;  Caldwell, Peter;  Davis, Kyle Frankel;  Debaere, Peter;  Hoekstra, Arjen Y.;  Li, Tianshu;  Marston, Landon;  McManamay, Ryan;  Mekonnen, Mesfin M.;  Ruddell, Benjamin L.;  Rushforth, Richard R.;  Troy, Tara J.
收藏  |  浏览/下载：12/0  |  提交时间：2020/05/13
Early atmospheric contamination on the top of the Himalayas since the onset of the European Industrial Revolution 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (8) : 3967-3973
作者:  Gabrielli, Paolo;  Wegner, Anna;  Sierra-Hernandez, M. Roxana;  Beaudon, Emilie;  Davis, Mary;  Barker, Joel D.;  Thompson, Lonnie G.
收藏  |  浏览/下载：8/0  |  提交时间：2020/05/13
ice cores  trace metals  paleoenvironment  monsoon  North Atlantic Oscillation  
Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data 期刊论文
NATURE GEOSCIENCE, 2020, 13 (3) : 213-+
作者:  Lognonne, P.;  Banerdt, W. B.;  Pike, W. T.;  Giardini, D.;  Christensen, U.;  Garcia, R. F.;  Kawamura, T.;  Kedar, S.;  Knapmeyer-Endrun, B.;  Margerin, L.;  Nimmo, F.;  Panning, M.;  Tauzin, B.;  Scholz, J. -R.;  Antonangeli, D.;  Barkaoui, S.;  Beucler, E.;  Bissig, F.;  Brinkman, N.;  Calvet, M.;  Ceylan, S.;  Charalambous, C.;  Davis, P.;  Van Driel, M.;  Drilleau, M.;  Fayon, L.;  Joshi, R.;  Kenda, B.;  Khan, A.;  Knapmeyer, M.;  Lekic, V.;  McClean, J.;  Mimoun, D.;  Murdoch, N.;  Pan, L.;  Perrin, C.;  Pinot, B.;  Pou, L.;  Menina, S.;  Rodriguez, S.;  Schmelzbach, C.;  Schmerr, N.;  Sollberger, D.;  Spiga, A.;  Staehler, S.;  Stott, A.;  Stutzmann, E.;  Tharimena, S.;  Widmer-Schnidrig, R.;  Andersson, F.;  Ansan, V.;  Beghein, C.;  Boese, M.;  Bozdag, E.;  Clinton, J.;  Daubar, I.;  Delage, P.;  Fuji, N.;  Golombek, M.;  Grott, M.;  Horleston, A.;  Hurst, K.;  Irving, J.;  Jacob, A.;  Knollenberg, J.;  Krasner, S.;  Krause, C.;  Lorenz, R.;  Michaut, C.;  Myhill, R.;  Nissen-Meyer, T.;  Ten Pierick, J.;  Plesa, A. -C.;  Quantin-Nataf, C.;  Robertsson, J.;  Rochas, L.;  Schimmel, M.;  Smrekar, S.;  Spohn, T.;  Teanby, N.;  Tromp, J.;  Vallade, J.;  Verdier, N.;  Vrettos, C.;  Weber, R.;  Banfield, D.;  Barrett, E.;  Bierwirth, M.;  Calcutt, S.;  Compaire, N.;  Johnson, C. L.;  Mance, D.;  Euchner, F.;  Kerjean, L.;  Mainsant, G.;  Mocquet, A.;  Rodriguez Manfredi, J. A.;  Pont, G.;  Laudet, P.;  Nebut, T.;  De Raucourt, S.;  Robert, O.;  Russell, C. T.;  Sylvestre-Baron, A.;  Tillier, S.;  Warren, T.;  Wieczorek, M.;  Yana, C.;  Zweifel, P.
收藏  |  浏览/下载：20/0  |  提交时间：2020/05/13