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Automatic precursor recognition and real-time forecasting of sudden explosive volcanic eruptions at Whakaari, New Zealand 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Dempsey, D. E.;  Cronin, S. J.;  Mei, S.;  Kempa-Liehr, A. W.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/21
Improving the prediction of an atmospheric chemistry transport model using gradient-boosted regression trees 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8063-8082
作者:  Ivatt, Peter D.;  Evans, Mathew J.
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/21
Characterizing soundscapes across diverse ecosystems using a universal acoustic feature set 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (29) : 17049-17055
作者:  Sethi, Sarab S.;  Jones, Nick S.;  Fulcher, Ben D.;  Picinali, Lorenzo;  Clink, Dena Jane;  Klinck, Holger;  Orme, C. David L.;  Wrege, Peter H.;  Ewers, Robert M.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/09
machine learning  acoustic  soundscape  monitoring  ecology  
Stable machine-learning parameterization of subgrid processes for climate modeling at a range of resolutions 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Yuval, Janni;  39;Gorman, Paul A.
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/06
Spatio-temporal variation of reference evapotranspiration in northwest China based on CORDEX-EA 期刊论文
ATMOSPHERIC RESEARCH, 2020, 238
作者:  Yang, Linshan;  Feng, Qi;  Adamowski, Jan F.;  Yin, Zhenliang;  Wen, Xiaohu;  Wu, Min;  Jia, Bing;  Hao, Qiang
收藏  |  浏览/下载：14/0  |  提交时间：2020/08/18
CORDEX-EA  Reference evapotranspiration  Machine learning algorithm  Northwest China  
Linking large-scale circulation patterns to low-cloud properties 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7125-7138
作者:  Juliano, Timothy W.;  Lebo, Zachary J.
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/22
Quantifying the drivers and predictability of seasonal changes in African fire 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Yu, Yan;  Mao, Jiafu;  Thornton, Peter E.;  Notaro, Michael;  Wullschleger, Stan D.;  Shi, Xiaoying;  Hoffman, Forrest M.;  Wang, Yaoping
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/16
Dynamic spatial-temporal precipitation distribution models for short-duration rainstorms in Shenzhen, China based on machine learning 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Liu, Yuan-Yuan;  Li, Lei;  Liu, Ye-Sen;  Chan, Pak Wai;  Zhang, Wen-Hai
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/02
Short-duration rainstorm  Machine learning  Locally linear embedding method  Dynamic spatial-temporal distribution  Shenzhen  
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Developing a novel hybrid model for the estimation of surface 8 h ozone (O-3) across the remote Tibetan Plateau during 2005-2018 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 6159-6175
作者:  Li, Rui;  Zhao, Yilong;  Zhou, Wenhui;  Meng, Ya;  Zhang, Ziyu;  Fu, Hongbo
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/01