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groundwater along a stream network affects the source composition of discharge 期刊论文
Water Resources Research, 2021
作者:  Zhi-Yuan Zhang;  Christian Schmidt;  Erik Nixdorf;  Xingxing Kuang;  Jan H. Fleckenstein
收藏  |  浏览/下载:25/0  |  提交时间:2021/07/27
Phosphorus addition decreases microbial residual contribution to soil organic carbon pool in a tropical coastal forest 期刊论文
Global Change Biology, 2020
作者:  Ye Yuan;  Yue Li;  Zhijian Mou;  Luhui Kuang;  Wenjia Wu;  Jing Zhang;  Faming Wang;  Dafeng Hui;  Josep Peñ;  uelas;  Jordi Sardans;  Hans Lambers;  Jun Wang;  Yuanwen Kuang;  Zhi’;  an Li;  Zhanfeng Liu
收藏  |  浏览/下载:7/0  |  提交时间:2020/11/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Emissions and health impacts from global shipping embodied in US-China bilateral trade 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (11) : 1027-1033
作者:  Liu, Huan;  Meng, Zhi-Hang;  Lv, Zhao-Feng;  Wang, Xiao-Tong;  Deng, Fan-Yuan;  Liu, Yang;  Zhang, Yan-Ni;  Shi, Meng-Shuang;  Zhang, Qiang;  He, Ke-Bin
收藏  |  浏览/下载:16/0  |  提交时间:2020/02/16
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Heterozygous diploid and interspecies SCRaMbLEing 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Shen, Michael J.;  Wu, Yi;  Yang, Kun;  Li, Yunxiang;  Xu, Hui;  Zhang, Haoran;  Li, Bing-Zhi;  Li, Xia;  Xiao, Wen-Hai;  Zhou, Xiao;  Mitchell, Leslie A.;  Bader, Joel S.;  Yuan, Yingjin;  Boeke, Jef D.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Room-temperature chiral charge pumping in Dirac semimetals 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Zhang, Cheng;  Zhang, Enze;  Wang, Weiyi;  Liu, Yanwen;  Chen, Zhi-Gang;  Lu, Shiheng;  Liang, Sihang;  Cao, Junzhi;  Yuan, Xiang;  Tang, Lei;  Li, Qian;  Zhou, Chao;  Gu, Teng;  Wu, Yizheng;  Zou, Jin;  Xiu, Faxian
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Effects of tree size heterogeneity on carbon sink in old forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 432: 637-648
作者:  Shu, Shu-miao;  Zhu, Wan-ze;  Wang, Wen-zhi;  Jia, Min;  Zhang, Yuan-yuan;  Sheng, Zhe-liang
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Carbon sink  Carbon use efficiency  Carbon neutral hypothesis  Old forest  Individual size  Subalpine fir forest  
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27