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The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning 期刊论文
Environmental Health Perspectives, 2021
作者:  Skylar W. Marvel;  John S. House;  Matthew Wheeler;  Kuncheng Song;  Yi-Hui Zhou;  Fred A. Wright;  Weihsueh A. Chiu;  Ivan Rusyn;  Alison Motsinger-Reif;  David M. Reif
收藏  |  浏览/下载:6/0  |  提交时间:2021/01/15
Mapping carbon accumulation potential from global natural forest regrowth 期刊论文
Nature, 2020
作者:  Susan C. Cook-Patton;  Sara M. Leavitt;  David Gibbs;  Nancy L. Harris;  Kristine Lister;  Kristina J. Anderson-Teixeira;  Russell D. Briggs;  Robin L. Chazdon;  Thomas W. Crowther;  Peter W. Ellis;  Heather P. Griscom;  Valentine Herrmann;  Karen D. Holl;  Richard A. Houghton;  Cecilia Larrosa;  Guy Lomax;  Richard Lucas;  Palle Madsen;  Yadvinder Malhi;  Alain Paquette;  John D. Parker;  Keryn Paul;  Devin Routh;  Stephen Roxburgh;  Sassan Saatchi;  Johan van den Hoogen;  Wayne S. Walker;  Charlotte E. Wheeler;  Stephen A. Wood;  Liang Xu;  Bronson W. Griscom
收藏  |  浏览/下载:11/0  |  提交时间:2020/09/30
Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage 期刊论文
Science, 2020
作者:  Aurélie Fluckiger;  Romain Daillère;  Mohamed Sassi;  Barbara Susanne Sixt;  Peng Liu;  Friedemann Loos;  Corentin Richard;  Catherine Rabu;  Maryam Tidjani Alou;  Anne-Gaëlle Goubet;  Fabien Lemaitre;  Gladys Ferrere;  Lisa Derosa;  Connie P. M. Duong;  Meriem Messaoudene;  Andréanne Gagné;  Philippe Joubert;  Luisa De Sordi;  Laurent Debarbieux;  Sylvain Simon;  Clara-Maria Scarlata;  Maha Ayyoub;  Belinda Palermo;  Francesco Facciolo;  Romain Boidot;  Richard Wheeler;  Ivo Gomperts Boneca;  Zsofia Sztupinszki;  Krisztian Papp;  Istvan Csabai;  Edoardo Pasolli;  Nicola Segata;  Carlos Lopez-Otin;  Zoltan Szallasi;  Fabrice Andre;  Valerio Iebba;  Valentin Quiniou;  David Klatzmann;  Jacques Boukhalil;  Saber Khelaifia;  Didier Raoult;  Laurence Albiges;  Bernard Escudier;  Alexander Eggermont;  Fathia Mami-Chouaib;  Paola Nistico;  François Ghiringhelli;  Bertrand Routy;  Nathalie Labarrière;  Vincent Cattoir;  Guido Kroemer;  Laurence Zitvogel
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/25
Active restoration accelerates the carbon recovery of human-modified tropical forests 期刊论文
Science, 2020
作者:  Christopher D. Philipson;  Mark E. J. Cutler;  Philip G. Brodrick;  Gregory P. Asner;  Doreen S. Boyd;  Pedro Moura Costa;  Joel Fiddes;  Giles M. Foody;  Geertje M. F. van der Heijden;  Alicia Ledo;  Philippa R. Lincoln;  James A. Margrove;  Roberta E. Martin;  Sol Milne;  Michelle A. Pinard;  Glen Reynolds;  Martijn Snoep;  Hamzah Tangki;  Yap Sau Wai;  Charlotte E. Wheeler;  David F. R. P. Burslem
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/18
Flash droughts present a new challenge for subseasonal-to-seasonal prediction 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (3) : 191-199
作者:  Pendergrass, Angeline G.;  Meehl, Gerald A.;  Pulwarty, Roger;  Hobbins, Mike;  Hoell, Andrew;  AghaKouchak, Amir;  Bonfils, Celine J. W.;  Gallant, Ailie J. E.;  Hoerling, Martin;  Hoffmann, David;  Kaatz, Laurna;  Lehner, Flavio;  Llewellyn, Dagmar;  Mote, Philip;  Neale, Richard B.;  Overpeck, Jonathan T.;  Sheffield, Amanda;  Stahl, Kerstin;  Svoboda, Mark;  Wheeler, Matthew C.;  Wood, Andrew W.;  Woodhouse, Connie A.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
Ice front blocking of ocean heat transport to an Antarctic ice shelf 期刊论文
NATURE, 2020, 578 (7796) : 568-+
作者:  Alexandrov, Ludmil B.;  Kim, Jaegil;  Haradhvala, Nicholas J.;  Huang, Mi Ni;  Ng, Alvin Wei Tian;  Wu, Yang;  Boot, Arnoud;  Covington, Kyle R.;  Gordenin, Dmitry A.;  Bergstrom, Erik N.;  Islam, S. M. Ashiqul;  Lopez-Bigas, Nuria;  Klimczak, Leszek J.;  McPherson, John R.;  Morganella, Sandro;  Sabarinathan, Radhakrishnan;  Wheeler, David A.;  Mustonen, Ville;  Getz, Gad;  Rozen, Steven G.;  Stratton, Michael R.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13

The front of the Getz Ice Shelf in West Antarctica creates an abrupt topographic step that deflects ocean currents, suppressing 70% of the heat delivery to the ice sheet.


Mass loss from the Antarctic Ice Sheet to the ocean has increased in recent decades, largely because the thinning of its floating ice shelves has allowed the outflow of grounded ice to accelerate(1,2). Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), motivating a recent focus on the processes that control ocean heat transport onto and across the seabed of the Antarctic continental shelf towards the ice(4-6). However, the shoreward heat flux typically far exceeds that required to match observed melt rates(2,7,8), suggesting that other critical controls exist. Here we show that the depth-independent (barotropic) component of the heat flow towards an ice shelf is blocked by the marked step shape of the ice front, and that only the depth-varying (baroclinic) component, which is typically much smaller, can enter the sub-ice cavity. Our results arise from direct observations of the Getz Ice Shelf system and laboratory experiments on a rotating platform. A similar blocking of the barotropic component may occur in other areas with comparable ice-bathymetry configurations, which may explain why changes in the density structure of the water column have been found to be a better indicator of basal melt rate variability than the heat transported onto the continental shelf(9). Representing the step topography of the ice front accurately in models is thus important for simulating ocean heat fluxes and induced melt rates.


  
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Anisotropic diffusion creep in postperovskite provides a new model for deformation at the core−mantle boundary 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (52) : 26389-26393
作者:  David P. Dobson;  Alexander Lindsay-Scott;  Simon A. Hunt;  Edward Bailey;  Ian G. Wood;  John P. Brodholt;  Lidunka Vocadlo;  John Wheeler
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/18
postperovskite  D”  diffusion creep  anisotropy  
Anisotropic diffusion creep in postperovskite provides a new model for deformation at the core−mantle boundary 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (52) : 26389-26393
作者:  David P. Dobson;  Alexander Lindsay-Scott;  Simon A. Hunt;  Edward Bailey;  Ian G. Wood;  John P. Brodholt;  Lidunka Vocadlo;  and John Wheeler
收藏  |  浏览/下载:6/0  |  提交时间:2020/04/16
postperovskite  D”  diffusion creep  anisotropy  
The Impact of Aquatic Salinization on Fish Habitats and Poor Communities in a Changing Climate: Evidence from Southwest Coastal Bangladesh 期刊论文
ECOLOGICAL ECONOMICS, 2017, 139
作者:  Dasgupta, Susmita;  Huq, Mainul;  Mustafa, Md. Golam;  Sobhan, Md. Istiak;  Wheeler, David
收藏  |  浏览/下载:0/0  |  提交时间:2019/04/09
Climate change  Aquatic salinization  Fish habitats  Poverty  Bangladesh