Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

doi:10.1126/science.aax0701

GSTDTAP > 气候变化

DOI	10.1126/science.aax0701
	Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage
	Aurélie Fluckiger; Romain Daillère; Mohamed Sassi; Barbara Susanne Sixt; Peng Liu; Friedemann Loos; Corentin Richard; Catherine Rabu; Maryam Tidjani Alou; Anne-Gaëlle Goubet; Fabien Lemaitre; Gladys Ferrere; Lisa Derosa; Connie P. M. Duong; Meriem Messaoudene; Andréanne Gagné; Philippe Joubert; Luisa De Sordi; Laurent Debarbieux; Sylvain Simon; Clara-Maria Scarlata; Maha Ayyoub; Belinda Palermo; Francesco Facciolo; Romain Boidot; Richard Wheeler; Ivo Gomperts Boneca; Zsofia Sztupinszki; Krisztian Papp; Istvan Csabai; Edoardo Pasolli; Nicola Segata; Carlos Lopez-Otin; Zoltan Szallasi; Fabrice Andre; Valerio Iebba; Valentin Quiniou; David Klatzmann; Jacques Boukhalil; Saber Khelaifia; Didier Raoult; Laurence Albiges; Bernard Escudier; Alexander Eggermont; Fathia Mami-Chouaib; Paola Nistico; François Ghiringhelli; Bertrand Routy; Nathalie Labarrière; Vincent Cattoir; Guido Kroemer; Laurence Zitvogel
	2020-08-21
发表期刊	Science
出版年	2020
英文摘要	Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger et al. report microbial antigens that might cross-react with antigens associated with tumor cells. They found that a type of intestinal bacteria called enterococci harbor a bacteriophage that modulates immune responses. In mouse models, administration of enterococci containing the bacteriophage boosted T cell responses after treatment with chemotherapy or programmed cell death protein 1 (PD-1) blockade. In humans, the presence of the bacteriophage was associated with improved survival after PD-1 immunotherapy. A fraction of human T cells specific for naturally processed melanoma epitopes appeared to be able to recognize microbial peptides. This “molecular mimicry” may represent cross-reactivity between tumors and microbial antigens. Science , this issue p. [936][1] Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I–binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae . Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb–restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti–PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP–cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected. [1]: /lookup/doi/10.1126/science.aax0701
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/291212
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Aurélie Fluckiger,Romain Daillère,Mohamed Sassi,等. Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage[J]. Science,2020.
APA	Aurélie Fluckiger.,Romain Daillère.,Mohamed Sassi.,Barbara Susanne Sixt.,Peng Liu.,...&Laurence Zitvogel.(2020).Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage.Science.
MLA	Aurélie Fluckiger,et al."Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage".Science (2020).