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How will baseflow respond to climate change in the Upper Colorado River Basin? 期刊论文
Geophysical Research Letters, 2021
作者:  Olivia L. Miller;  Matthew P. Miller;  Patrick C. Longley;  Jay R. Alder;  Lindsay A. Bearup;  Tom Pruitt;  Daniel K. Jones;  Annie L. Putman;  Christine A. Rumsey;  Tim McKinney
收藏  |  浏览/下载：8/0  |  提交时间：2021/11/15
Rising Debt Burdens, The Impact on Public Spending, and the Coronavirus Crisis 科技报告
来源：Center for Global Development. 出版年： 2020
作者:  Tim Jones
收藏  |  浏览/下载：0/0  |  提交时间：2020/12/22
Honey bee virus causes context-dependent changes in host social behavior 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10406-10413
作者:  Geffre, Amy C.;  Gernat, Tim;  Harwood, Gyan P.;  Jones, Beryl M.;  Gysi, Deisy Morselli;  Hamilton, Adam R.;  Bonning, Bryony C.;  Toth, Amy L.;  Robinson, Gene E.;  Dolezal, Adam G.
收藏  |  浏览/下载：8/0  |  提交时间：2020/05/13
honey bee  virus  host-pathogen evolution  pathogen manipulation  
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载：12/0  |  提交时间：2020/02/17
An anatomic transcriptional atlas of human glioblastoma 期刊论文
SCIENCE, 2018, 360 (6389) : 660-663
作者:  Puchalski, Ralph B.;  Shah, Nameeta;  Miller, Jeremy;  Dalley, Rachel;  Nomura, Steve R.;  Yoon, Jae-Guen;  Smith, Kimberly A.;  Lankerovich, Michael;  Bertagnolli, Darren;  Bickley, Kris;  Boe, Andrew F.;  Brouner, Krissy;  Butler, Stephanie;  Caldejon, Shiella;  Chapin, Mike;  Datta, Suvro;  Dee, Nick;  Desta, Tsega;  Dolbeare, Tim;  Dotson, Nadezhda;  Ebbert, Amanda;  Feng, David;  Feng, Xu;  Fisher, Michael;  Gee, Garrett;  Goldy, Jeff;  Gourley, Lindsey;  Gregor, Benjamin W.;  Gu, Guangyu;  Hejazinia, Nika;  Hohmann, John;  Hothi, Parvinder;  Howard, Robert;  Joines, Kevin;  Kriedberg, Ali;  Kuan, Leonard;  Lau, Chris;  Lee, Felix;  Lee, Hwahyung;  Lemon, Tracy;  Long, Fuhui;  Mastan, Naveed;  Mott, Erika;  Murthy, Chantal;  Ngo, Kiet;  Olson, Eric;  Reding, Melissa;  Riley, Zack;  Rosen, David;  Sandman, David;  Shapovalova, Nadiya;  Slaughterbeck, Clifford R.;  Sodt, Andrew;  Stockdale, Graham;  Szafer, Aaron;  Wakeman, Wayne;  Wohnoutka, Paul E.;  White, Steven J.;  Marsh, Don;  Rostomily, Robert C.;  Ng, Lydia;  Dang, Chinh;  Jones, Allan;  Keogh, Bart;  Gittleman, Haley R.;  Barnholtz-Sloan, Jill S.;  Cimino, Patrick J.;  Uppin, Megha S.;  Keene, C. Dirk;  Farrokhi, Farrokh R.;  Lathia, Justin D.;  Berens, Michael E.;  Iavarone, Antonio;  Bernard, Amy;  Lein, Ed;  Phillips, John W.;  Rostad, Steven W.;  Cobbs, Charles;  Hawrylycz, Michael J.;  Foltz, Greg D.
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/27
A global synthesis of the effects of diversified farming systems on arthropod diversity within fields and across agricultural landscapes 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Lichtenberg, Elinor M.;  Kennedy, Christina M.;  Kremen, Claire;  Batary, Peter;  Berendse, Frank;  Bommarco, Riccardo;  Bosque-Perez, Nilsa A.;  Carvalheiro, Luisa G.;  Snyder, William E.;  Williams, Neal M.;  Winfree, Rachael;  Klatt, Bjoern K.;  Astrom, Sandra;  Benjamin, Faye;  Brittain, Claire;  Chaplin-Kramer, Rebecca;  Clough, Yann;  Danforth, Bryan;  Diekoetter, Tim;  Eigenbrode, Sanford D.;  Ekroos, Johan;  Elle, Elizabeth;  Freitas, Breno M.;  Fukuda, Yuki;  Gaines-Day, Hannah R.;  Grab, Heather;  Gratton, Claudio;  Holzschuh, Andrea;  Isaacs, Rufus;  Isaia, Marco;  Jha, Shalene;  Jonason, Dennis;  Jones, Vincent P.;  Klein, Alexandra-Maria;  Krauss, Jochen;  Letourneau, Deborah K.;  Macfadyen, Sarina;  Mallinger, Rachel E.;  Martin, Emily A.;  Martinez, Eliana;  Memmott, Jane;  Morandin, Lora;  Neame, Lisa;  Otieno, Mark;  Park, Mia G.;  Pfiffner, Lukas;  Pocock, Michael J. O.;  Ponce, Carlos;  Potts, Simon G.;  Poveda, Katja;  Ramos, Mariangie;  Rosenheim, Jay A.;  Rundlof, Maj;  Sardinas, Hillary;  Saunders, Manu E.;  Schon, Nicole L.;  Sciligo, Amber R.;  Sidhu, C. Sheena;  Steffan-Dewenter, Ingolf;  Tscharntke, Teja;  Vesely, Milan;  Weisser, Wolfgang W.;  Wilson, Julianna K.;  Crowder, David W.
收藏  |  浏览/下载：20/0  |  提交时间：2019/04/09
agricultural management schemes  arthropod diversity  biodiversity  evenness  functional groups  landscape complexity  meta-analysis  organic farming  plant diversity  
Assessing mid-latitude dynamics in extreme event attribution systems 期刊论文
CLIMATE DYNAMICS, 2017, 48 (11)
作者:  Mitchell, Daniel;  Davini, Paolo;  Harvey, Ben;  Massey, Neil;  Haustein, Karsten;  Woollings, Tim;  Jones, Richard;  Otto, Fredi;  Guillod, Benoit;  Sparrow, Sarah;  Wallom, David;  Allen, Myles
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Event attribution  Dynamics  Mid-latitudes  Extreme