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DOI | 10.1126/science.aaf2666 |
An anatomic transcriptional atlas of human glioblastoma | |
Puchalski, Ralph B.1,2; Shah, Nameeta1,2,3; Miller, Jeremy1; Dalley, Rachel1; Nomura, Steve R.2; Yoon, Jae-Guen2; Smith, Kimberly A.1; Lankerovich, Michael2; Bertagnolli, Darren1; Bickley, Kris1; Boe, Andrew F.1; Brouner, Krissy1; Butler, Stephanie1; Caldejon, Shiella1; Chapin, Mike1; Datta, Suvro1; Dee, Nick1; Desta, Tsega1; Dolbeare, Tim1; Dotson, Nadezhda1; Ebbert, Amanda1; Feng, David1; Feng, Xu4; Fisher, Michael1; Gee, Garrett1; Goldy, Jeff1; Gourley, Lindsey1; Gregor, Benjamin W.1; Gu, Guangyu1; Hejazinia, Nika1; Hohmann, John1; Hothi, Parvinder2; Howard, Robert1; Joines, Kevin1; Kriedberg, Ali1; Kuan, Leonard1; Lau, Chris1; Lee, Felix1; Lee, Hwahyung2; Lemon, Tracy1; Long, Fuhui1; Mastan, Naveed1; Mott, Erika1; Murthy, Chantal2; Ngo, Kiet1; Olson, Eric1; Reding, Melissa1; Riley, Zack1; Rosen, David1; Sandman, David1; Shapovalova, Nadiya1; Slaughterbeck, Clifford R.1; Sodt, Andrew1; Stockdale, Graham1; Szafer, Aaron1; Wakeman, Wayne1; Wohnoutka, Paul E.1; White, Steven J.5; Marsh, Don5; Rostomily, Robert C.6,7; Ng, Lydia1; Dang, Chinh1; Jones, Allan1; Keogh, Bart4; Gittleman, Haley R.8; Barnholtz-Sloan, Jill S.8; Cimino, Patrick J.9; Uppin, Megha S.10; Keene, C. Dirk9; Farrokhi, Farrokh R.11; Lathia, Justin D.12; Berens, Michael E.13; Iavarone, Antonio14,15,16; Bernard, Amy1; Lein, Ed1; Phillips, John W.1; Rostad, Steven W.2,17; Cobbs, Charles2; Hawrylycz, Michael J.1; Foltz, Greg D.2 | |
2018-05-11 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6389页码:660-663 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; India |
英文摘要 | Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431790900047 |
WOS关键词 | HETEROGENEITY ; EXPRESSION ; SUBTYPES ; TUMORS ; CELLS ; TEMOZOLOMIDE ; MULTIFORME ; MUTATIONS ; INVASION ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198632 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Allen Inst Brain Sci, Seattle, WA 98109 USA; 2.Swedish Neurosci Inst, Ben & Catherine Ivy Ctr Adv Brain Tumor Treatment, Seattle, WA 98122 USA; 3.Mazumdar Shaw Ctr Translat Res, Bangalore 560099, Karnataka, India; 4.Radia Inc, Lynnwood, WA 98036 USA; 5.White Marsh Forests, Seattle, WA 98119 USA; 6.Univ Washington, Sch Med, Dept Neurosurg, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA; 7.Houston Methodist Hosp & Res Inst, Dept Neurol Surg, Houston, TX 77030 USA; 8.Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA; 9.Univ Washington, Sch Med, Dept Pathol, Div Neuropathol, Seattle, WA 98104 USA; 10.Nizams Inst Med Sci, Hyderabad 500082, Andhra Prades, India; 11.Virginia Mason Med Ctr, Seattle, WA 98101 USA; 12.Cleveland Clin, Dept Cellular & Mol Med, Cleveland, OH 44195 USA; 13.TGen, Translat Genom Res Inst, Phoenix, AZ 85004 USA; 14.Columbia Univ, Inst Canc Genet, New York, NY 10032 USA; 15.Columbia Univ, Dept Neurol, New York, NY 10032 USA; 16.Columbia Univ, Dept Pathol, New York, NY 10032 USA; 17.CellNetix, Seattle, WA 98122 USA |
推荐引用方式 GB/T 7714 | Puchalski, Ralph B.,Shah, Nameeta,Miller, Jeremy,et al. An anatomic transcriptional atlas of human glioblastoma[J]. SCIENCE,2018,360(6389):660-663. |
APA | Puchalski, Ralph B..,Shah, Nameeta.,Miller, Jeremy.,Dalley, Rachel.,Nomura, Steve R..,...&Foltz, Greg D..(2018).An anatomic transcriptional atlas of human glioblastoma.SCIENCE,360(6389),660-663. |
MLA | Puchalski, Ralph B.,et al."An anatomic transcriptional atlas of human glioblastoma".SCIENCE 360.6389(2018):660-663. |
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