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Exposure to PM2.5 during Pregnancy and Fetal Growth in Eastern Massachusetts, USA 期刊论文
Environmental Health Perspectives, 2022
作者:  Michael Leung;  Marc G. Weisskopf;  Francine Laden;  Brent A. Coull;  Anna M. Modest;  Michele R. Hacker;  Blair J. Wylie;  Yaguang Wei;  Joel Schwartz;  Stefania Papatheodorou
收藏  |  浏览/下载:18/0  |  提交时间:2022/01/29
Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study 期刊论文
Environmental Health Perspectives, 2021
作者:  Michael Leung;  Marianthi-Anna Kioumourtzoglou;  Raanan Raz;  Marc G. Weisskopf
收藏  |  浏览/下载:8/0  |  提交时间:2021/04/06
Comparison of equilibrium climate sensitivity estimates from slab ocean, 150‐year, and longer simulations 期刊论文
Geophysical Research Letters, 2020
作者:  John P. Dunne;  Michael Winton;  Julio Bacmeister;  Gokhan Danabasoglu;  Andrew Gettelman;  Jean‐;  Christophe Golaz;  Cecile Hannay;  Gavin A. Schmidt;  John P. Krasting;  L. Ruby Leung;  Larissa Nazarenko;  Lori T. Sentman;  Ronald J. Stouffer;  Jonathan D. Wolfe
收藏  |  浏览/下载:17/0  |  提交时间:2020/08/09
Drivers of future alien species impacts: An expert‐based assessment 期刊论文
Global Change Biology, 2020
作者:  Franz Essl;  Bernd Lenzner;  Sven Bacher;  Sarah Bailey;  Cesar Capinha;  Curtis Daehler;  Stefan Dullinger;  Piero Genovesi;  Cang Hui;  Philip E. Hulme;  Jonathan M. Jeschke;  Stelios Katsanevakis;  Ingolf Kü;  hn;  Brian Leung;  Andrew Liebhold;  Chunlong Liu;  Hugh J. MacIsaac;  Laura A. Meyerson;  Martin A. Nuñ;  ez;  Aní;  bal Pauchard;  Petr Pyš;  ek;  Wolfgang Rabitsch;  David M. Richardson;  Helen E. Roy;  Gregory M. Ruiz;  James C. Russell;  Nathan J. Sanders;  Dov F. Sax;  Riccardo Scalera;  Hanno Seebens;  Michael Springborn;  Anna Turbelin;  Mark van Kleunen;  Betsy von Holle;  Marten Winter;  Rafael D. Zenni;  Brady J. Mattsson;  Nuria Roura‐;  Pascual
收藏  |  浏览/下载:12/0  |  提交时间:2020/08/09
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms 期刊论文
NATURE, 2020, 579 (7800) : 603-+
作者:  Xu, Wanghuai;  Zheng, Huanxi;  Liu, Yuan;  Zhou, Xiaofeng;  Zhang, Chao;  Song, Yuxin;  Deng, Xu;  Leung, Michael;  Yang, Zhengbao;  Xu, Ronald X.;  Wang, Zhong Lin;  Zeng, Xiao Cheng;  Wang, Zuankai
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/03

Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption(1). Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers(1,2). Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi anaemia (FA), a disease resulting in failure to produce blood cells and a predisposition to cancer(3,4). The combined inactivation of acetaldehyde detoxification and the FA pathway induces mutation, accelerates malignancies and causes the rapid attrition of blood stem cells(5-7). However, the nature of the DNA damage induced by acetaldehyde and how this is repaired remains a key question. Here we generate acetaldehyde-induced DNA interstrand crosslinks and determine their repair mechanism in Xenopus egg extracts. We find that two replication-coupled pathways repair these lesions. The first is the FA pathway, which operates using excision-analogous to the mechanism used to repair the interstrand crosslinks caused by the chemotherapeutic agent cisplatin. However, the repair of acetaldehyde-induced crosslinks results in increased mutation frequency and an altered mutational spectrum compared with the repair of cisplatin-induced crosslinks. The second repair mechanism requires replication fork convergence, but does not involve DNA incisions-instead the acetaldehyde crosslink itself is broken. The Y-family DNA polymerase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum. These results define the repair pathways of DNA interstrand crosslinks caused by an endogenous and alcohol-derived metabolite, and identify an excision-independent mechanism.


DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.


  
North American extreme precipitation events and related large-scale meteorological patterns: a review of statistical methods, dynamics, modeling, and trends 期刊论文
CLIMATE DYNAMICS, 2019, 53 (11) : 6835-6875
作者:  Barlow, Mathew;  Gutowski, William J.;  Gyakum, John R.;  Katz, Richard W.;  Lim, Young-Kwon;  Schumacher, Russ S.;  Wehner, Michael F.;  Agel, Laurie;  Bosilovich, Michael;  Collow, Allison;  Gershunov, Alexander;  Grotjahn, Richard;  Leung, Ruby;  Milrad, Shawn;  Min, Seung-Ki
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
When pets become pests: the role of the exotic pet trade in producing invasive vertebrate animals 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2019, 17 (6) : 323-330
作者:  Lockwood, Julie L.;  Welbourne, Dustin J.;  Romagosa, Christina M.;  Cassey, Phillip;  Mandrak, Nicholas E.;  Strecker, Angela;  Leung, Brian;  Stringham, Oliver C.;  Udell, Bradley;  Episcopio-Sturgeon, Diane J.;  Tlusty, Michael F.;  Sinclair, James;  Springborn, Michael R.;  Pienaar, Elizabeth F.;  Rhyne, Andrew L.;  Keller, Reuben
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27