Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP7961 |
Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study | |
Michael Leung; Marianthi-Anna Kioumourtzoglou; Raanan Raz; Marc G. Weisskopf | |
2021-04-01 | |
发表期刊 | Environmental Health Perspectives
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出版年 | 2021 |
英文摘要 | AbstractBackground:Studies of the effects of prenatal environmental exposures on postnatal outcomes are particularly vulnerable to live birth bias; i.e., the bias that arises from the necessary restriction of the analysis to live births when that is influenced by both the exposure under study and unmeasured factors that also affect the outcome. Objectives:In the context of a recent publication of nitrogen dioxide () and autism spectrum disorder (ASD) that found an odds ratio (OR) of 0.77 per during pregnancy, we aimed to examine what parameters would be needed to account for this protective association through live birth bias. Methods:We simulated the magnitude of bias under two selection mechanisms and when both mechanisms co-occur, assuming a true null effect. Simulation input parameters were based on characteristics of the original study and a range of plausible values for the prevalence of unmeasured factor and the ORs for the selection effects (i.e., the effects of and on loss and of on ASD). Each scenario was simulated 1,000 times. Results:We found that the magnitude of bias was small when and independently influenced pregnancy loss (collider-stratification without interaction), was stronger when loss preferentially occurred in (depletion of susceptibles), and was strongest when both mechanisms worked together. For example, ORs of 3.0 for , -loss, -ASD, and U yielded ORs per of 0.95, 0.89, and 0.75 for the three scenarios, respectively. The bias is amplified with multiple , yielding ORs as low as 0.51. Discussion:Our simulations illustrate that live birth bias may lead to exposure–outcome associations that are biased downward, where the extent of the bias depends on the fetal selection mechanism, the strength of that selection, and the prevalence of U. https://doi.org/10.1289/EHP7961 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/320897 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Michael Leung,Marianthi-Anna Kioumourtzoglou,Raanan Raz,et al. Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study[J]. Environmental Health Perspectives,2021. |
APA | Michael Leung,Marianthi-Anna Kioumourtzoglou,Raanan Raz,&Marc G. Weisskopf.(2021).Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study.Environmental Health Perspectives. |
MLA | Michael Leung,et al."Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study".Environmental Health Perspectives (2021). |
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