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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice 期刊论文
Science, 2021
作者:  David R. Martinez;  Alexandra Schäfer;  Sarah R. Leist;  Gabriela De la Cruz;  Ande West;  Elena N. Atochina-Vasserman;  Lisa C. Lindesmith;  Norbert Pardi;  Robert Parks;  Maggie Barr;  Dapeng Li;  Boyd Yount;  Kevin O. Saunders;  Drew Weissman;  Barton F. Haynes;  Stephanie A. Montgomery;  Ralph S. Baric
收藏  |  浏览/下载:39/0  |  提交时间:2021/08/30
Response to Charlier et al.: Climate–Disease Feedbacks Mediated by Livestock Methane Emissions Are Plausible 期刊论文
Trends in Ecology & Evolution\, 2021
作者:  Vanessa O. Ezenwa:David J. Civitello:Aimée T. Classen:Brandon T. Barton:Daniel J. Becker:Maris Brenn-White:Sharon L. Deem:Susan Kutz:Matthew Malishev:Rachel M. Penczykowski:Daniel L. Preston:J. Trevor Vannatta:Amanda M. Koltz
收藏  |  浏览/下载:22/0  |  提交时间:2021/05/21
Increasing aridity will not offset CO2 fertilization in fast‐growing eucalypts with access to deep soil water 期刊论文
Global Change Biology, 2021
作者:  Daniel Nadal‐;  Sala;  Belinda E. Medlyn;  Nadine K. Ruehr;  Craig V. M. Barton;  David S. Ellsworth;  Carles Gracia;  David T. Tissue;  Mark G. Tjoelker;  Santi Sabaté
收藏  |  浏览/下载:20/0  |  提交时间:2021/04/06
Anthropogenic climate change impacts on copepod trait biogeography 期刊论文
Global Change Biology, 2021
作者:  Niall McGinty;  Andrew D. Barton;  Nicholas R. Record;  Zoe V. Finkel;  David G. Johns;  Charles A. Stock;  Andrew J. Irwin
收藏  |  浏览/下载:21/0  |  提交时间:2021/02/17
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth 期刊论文
Science, 2021
作者:  Ryan S. Roark;  Hui Li;  Wilton B. Williams;  Hema Chug;  Rosemarie D. Mason;  Jason Gorman;  Shuyi Wang;  Fang-Hua Lee;  Juliette Rando;  Mattia Bonsignori;  Kwan-Ki Hwang;  Kevin O. Saunders;  Kevin Wiehe;  M. Anthony Moody;  Peter T. Hraber;  Kshitij Wagh;  Elena E. Giorgi;  Ronnie M. Russell;  Frederic Bibollet-Ruche;  Weimin Liu;  Jesse Connell;  Andrew G. Smith;  Julia DeVoto;  Alexander I. Murphy;  Jessica Smith;  Wenge Ding;  Chengyan Zhao;  Neha Chohan;  Maho Okumura;  Christina Rosario;  Yu Ding;  Emily Lindemuth;  Anya M. Bauer;  Katharine J. Bar;  David Ambrozak;  Cara W. Chao;  Gwo-Yu Chuang;  Hui Geng;  Bob C. Lin;  Mark K. Louder;  Richard Nguyen;  Baoshan Zhang;  Mark G. Lewis;  Donald D. Raymond;  Nicole A. Doria-Rose;  Chaim A. Schramm;  Daniel C. Douek;  Mario Roederer;  Thomas B. Kepler;  Garnett Kelsoe;  John R. Mascola;  Peter D. Kwong;  Bette T. Korber;  Stephen C. Harrison;  Barton F. Haynes;  Beatrice H. Hahn;  George M. Shaw
收藏  |  浏览/下载:62/0  |  提交时间:2021/01/15
Infectious Diseases, Livestock, and Climate: A Vicious Cycle? 期刊论文
Trends in Ecology & Evolution\, 2020
作者:  Vanessa O. Ezenwa:David J. Civitello:Brandon T. Barton:Daniel J. Becker:Maris Brenn-White:Aimée T. Classen:Sharon L. Deem:Zoë E. Johnson:Susan Kutz:Matthew Malishev:Rachel M. Penczykowski:Daniel L. Preston:J. Trevor Vannatta:Amanda M. Koltz
收藏  |  浏览/下载:26/0  |  提交时间:2020/10/12
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:75/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Hva innebærer FNs klimapanels spesialrapporter om landarealer, hav og is og Naturpanelets globale rapport for Oslo 科技报告
来源:Center for International Climate Research. 出版年: 2020
作者:  Borgar Aamaas;  Erik Stange;  Solveig Aamodt;  Marit Sandstad;  Clemens Schwingshackl;  Trine Hay Setsås;  David Barton;  Merethe Dotterud Leiren;  Bob van Oort
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation 期刊论文
SCIENCE, 2019, 366 (6470) : 1215-+
作者:  Saunders, Kevin O.;  Wiehe, Kevin;  Tian, Ming;  Acharya, Priyamvada;  Bradley, Todd;  Alam, S. Munir;  Go, Eden P.;  Scearce, Richard;  Sutherland, Laura;  Henderson, Rory;  Hsu, Allen L.;  Borgnia, Mario J.;  Chen, Haiyan;  Lu, Xiaozhi;  Wu, Nelson R.;  Watts, Brian;  Jiang, Chuancang;  Easterhoff, David;  Cheng, Hwei-Ling;  McGovern, Kelly;  Waddicor, Peyton;  Chapdelaine-Williams, Aimee;  Eaton, Amanda;  Zhang, Jinsong;  Rountree, Wes;  Verkoczy, Laurent;  Tomai, Mark;  Lewis, Mark G.;  Desaire, Heather R.;  Edwards, Robert J.;  Cain, Derek W.;  Bonsignori, Mattia;  Montefiori, David;  Alt, Frederick W.;  Haynes, Barton F.
收藏  |  浏览/下载:46/0  |  提交时间:2020/02/17
Archaeological assessment reveals Earth's early transformation through land use 期刊论文
SCIENCE, 2019, 365 (6456) : 897-+
作者:  Stephens, Lucas;  Fuller, Dorian;  Boivin, Nicole;  Rick, Torben;  Gauthier, Nicolas;  Kay, Andrea;  Marwick, Ben;  Armstrong, Chelsey Geralda Denise;  Barton, C. Michael;  Denham, Tim;  Douglass, Kristina;  Driver, Jonathan;  Janz, Lisa;  Roberts, Patrick;  Rogers, J. Daniel;  Thakar, Heather;  Altaweel, Mark;  Johnson, Amber L.;  Sampietro Vattuone, Maria Marta;  Aldenderfer, Mark;  Archila, Sonia;  Artioli, Gilberto;  Bale, Martin T.;  Beach, Timothy;  Borrell, Ferran;  Braje, Todd;  Buckland, Philip I.;  Jimenez Cano, Nayeli Guadalupe;  Capriles, Jose M.;  Diez Castillo, Agustin;  Cilingiroglu, Ciler;  Cleary, Michelle Negus;  Conolly, James;  Coutros, Peter R.;  Covey, R. Alan;  Cremaschi, Mauro;  Crowther, Alison;  Der, Lindsay;  di Lernia, Savino;  Doershuk, John F.;  Doolittle, William E.;  Edwards, Kevin J.;  Erlandson, Jon M.;  Evans, Damian;  Fairbairn, Andrew;  Faulkner, Patrick;  Feinman, Gary;  Fernandes, Ricardo;  Fitzpatrick, Scott M.;  Fyfe, Ralph;  Garcea, Elena;  Goldstein, Steve;  Goodman, Reed Charles;  Guedes, Jade Dalpoim;  Herrmann, Jason;  Hiscock, Peter;  Hommel, Peter;  Horsburgh, K. Ann;  Hritz, Carrie;  Ives, John W.;  Junno, Aripekka;  Kahn, Jennifer G.;  Kaufman, Brett;  Kearns, Catherine;  Kidder, Tristram R.;  Lanoe, Francois;  Lawrence, Dan;  Lee, Gyoung-Ah;  Levin, Maureece J.;  Lindskoug, Henrik B.;  Antonio Lopez-Saez, Jose;  Macrae, Scott;  Marchant, Rob;  Marston, John M.;  McClure, Sarah;  Mccoy, Mark D.;  Miller, Alicia Ventresca;  Morrison, Michael;  Matuzeviciute, Giedre Motuzaite;  Mueller, Johannes;  Nayak, Ayushi;  Noerwidi, Sofwan;  Peres, Tanya M.;  Peterson, Christian E.;  Proctor, Lucas;  Randall, Asa R.;  Renette, Steve;  Schug, Gwen Robbins;  Ryzewski, Krysta;  Saini, Rakesh;  Scheinsohn, Vivian;  Schmidt, Peter;  Sebillaud, Pauline;  Seitsonen, Oula;  Simpson, Ian A.;  Soltysiak, Arkadiusz;  Speakman, Robert J.;  Spengler, Robert N.;  Steffen, Martina L.;  Storozum, Michael J.;  Strickland, Keir M.;  Thompson, Jessica;  Thurston, T. L.;  Ulm, Sean;  Ustunkaya, M. Cemre;  Welker, Martin H.;  West, Catherine;  Williams, Patrick Ryan;  Wright, David K.;  Wright, Nathan;  Zahir, Muhammad;  Zerboni, Andrea;  Beaudoin, Ella;  Garcia, Santiago Munevar;  Powell, Jeremy;  Thornton, Alexa;  Kaplan, Jed O.;  Gaillard, Marie-Jose;  Goldewijk, Kees Klein;  Ellis, Erle
收藏  |  浏览/下载:98/0  |  提交时间:2019/11/27