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Fine root dynamics across pantropical rainforest ecosystems 期刊论文
Global Change Biology, 2021
作者:  Walter Huaraca Huasco;  Terhi Riutta;  Cé;  cile A. J. Girardin;  Fernando Hancco Pacha;  Beisit L. Puma Vilca;  Sam Moore;  Sami W. Rifai;  Jhon del Aguila-Pasquel;  Alejandro Araujo Murakami;  Renata Freitag;  Alexandra C. Morel;  Sheleme Demissie;  Christopher E. Doughty;  Imma Oliveras;  Darcy F. Galiano Cabrera;  Liliana Durand Baca;  Filio Farfá;  n Amé;  zquita;  Javier E. Silva Espejo;  Antonio C.L. da Costa;  Erick Oblitas Mendoza;  Carlos Alberto Quesada;  Fidele Evouna Ondo;  Josué;  Edzang Ndong;  Kathryn J. Jeffery;  Vianet Mihindou;  Lee J. T. White;  Natacha N'ssi Bengone;  Forzia Ibrahim;  Shalom D. Addo-Danso;  Akwasi Duah-Gyamfi;  Gloria Djaney Djagbletey;  Kennedy Owusu-Afriyie;  Lucy Amissah;  Armel T. Mbou;  Toby R. Marthews;  Daniel B. Metcalfe;  Luiz E. O. Aragã;  o;  Ben H. Marimon-Junior;  Beatriz S. Marimon;  Noreen Majalap;  Stephen Adu-Bredu;  Katharine A. Abernethy;  Miles Silman;  Robert M. Ewers;  Patrick Meir;  Yadvinder Malhi
收藏  |  浏览/下载：18/0  |  提交时间：2021/06/15
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Global gene flow releases invasive plants from environmental constraints on genetic diversity 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (8) : 4218-4227
作者:  Smith, Annabel L.;  Hodkinson, Trevor R.;  Villellas, Jesus;  Catford, Jane A.;  Csergo, Anna Maria;  Blomberg, Simone P.;  Crone, Elizabeth E.;  Ehrlen, Johan;  Garcia, Maria B.;  Laine, Anna-Liisa;  Roach, Deborah A.;  Salguero-Gomez, Roberto;  Wardle, Glenda M.;  Childs, Dylan Z.;  Elderd, Bret D.;  Finn, Alain;  Munne-Bosch, Sergi;  Baudraz, Maude E. A.;  Bodis, Judit;  Brearley, Francis Q.;  Bucharova, Anna;  Caruso, Christina M.;  Duncan, Richard P.;  Dwyerh, Johnm.;  Gooden, Ben;  Groenteman, Ronny;  Hamre, Liv Norunn;  Helm, Aveliina;  Kelly, Ruth;  Laanisto, Lauri;  Lonati, Michele;  Moore, Joslin L.;  Morales, Melanie;  Olsen, Siri Lie;  Partel, Meelis;  Petry, William K.;  Ramula, Satu;  Rasmussen, Pil U.;  Enri, Simone Ravetto;  Roeder, Anna;  Roscher, Christiane;  Saastamoinen, Marjo;  Tack, Ayco J. M.;  Topper, Joachim Paul;  Vose, Gregory E.;  Wandrag, Elizabeth M.;  Wingler, Astrid;  Buckley, Yvonne M.
收藏  |  浏览/下载：5/0  |  提交时间：2020/05/13
plant invasion  adaptation  global change  population genetics  demography  
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载：10/0  |  提交时间：2020/02/17
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution 期刊论文
NATURE, 2017, 545 (7655) : 446-+
作者:  Abbosh, Christopher;  Birkbak, Nicolai J.;  Wilson, Gareth A.;  Jamal-Hanjani, Mariam;  Constantin, Tudor;  Salari, Raheleh;  Le Quesne, John;  Moore, David A.;  Veeriah, Selvaraju;  Rosenthal, Rachel;  Marafioti, Teresa;  Kirkizlar, Eser;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Ward, Sophia;  Martinson, Luke;  Riley, Joan;  Fraioli, Francesco;  Al Bakir, Maise;  Gronroos, Eva;  Zambrana, Francisco;  Endozo, Raymondo;  Bi, Wenya Linda;  Fennessy, Fiona M.;  Sponer, Nicole;  Johnson, Diana;  Laycock, Joanne;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Rowan, Andrew;  Chambers, Tim;  Matthews, Nik;  Turajlic, Samra;  Hiley, Crispin;  Lee, Siow Ming;  Forster, Martin D.;  Ahmad, Tanya;  Falzon, Mary;  Borg, Elaine;  Lawrence, David;  Hayward, Martin;  Kolvekar, Shyam;  Panagiotopoulos, Nikolaos;  Janes, Sam M.;  Thakrar, Ricky;  Ahmed, Asia;  Blackhall, Fiona;  Summers, Yvonne;  Hafez, Dina;  Naik, Ashwini;  Ganguly, Apratim;  Kareht, Stephanie;  Shah, Rajesh;  Joseph, Leena;  Quinn, Anne Marie;  Crosbie, Phil A.;  Naidu, Babu;  Middleton, Gary;  Langman, Gerald;  Trotter, Simon;  Nicolson, Marianne;  Remmen, Hardy;  Kerr, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Fennell, Dean A.;  Nakas, Apostolos;  Rathinam, Sridhar;  Anand, Girija;  Khan, Sajid;  Russell, Peter;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Lester, Jason F.;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Adams, Haydn;  Davies, Helen;  Oukrif, Dahmane;  Akarca, Ayse U.;  Hartley, John A.;  Lowe, Helen L.;  Lock, Sara;  Iles, Natasha;  Bell, Harriet;  Ngai, Yenting;  Elgar, Greg;  Szallasi, Zoltan;  Schwarz, Roland F.;  Herrero, Javier;  Stewart, Aengus;  Quezada, Sergio A.;  Peggs, Karl S.;  Van Loo, Peter;  Dive, Caroline;  Lin, C. Jimmy;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Hackshaw, Allan;  Shaw, Jacqui A.;  Zimmermann, Bernhard G.;  Swanton, Charles;  Jamal-Hanjani, Mariam;  Abbosh, Christopher;  Veeriah, Selvaraju;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Johnson, Diana;  Laycock, Joanne;  Bosshard-Carter, Leticia;  Goh, Gerald;  Rosenthal, Rachel;  Gorman, Pat;  Murugaesu, Nirupa;  Hynds, Robert E.;  Wilson, Gareth A.;  Birkbak, Nicolai J.;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Horswell, Stuart;  Al Bakir, Maise;  Gronroos, Eva;  Mitter, Richard;  Escudero, Mickael;  Stewart, Aengus;  Van Loo, Peter;  Rowan, Andrew;  Xu, Hang;  Turajlic, Samra;  Hiley, Crispin;  Goldman, Jacki;  Stone, Richard Kevin;  Denner, Tamara;  Matthews, Nik;  Elgar, Greg;  Ward, Sophia;  Biggs, Jennifer;  Costa, Marta;  Begum, Sharmin;  Phillimore, Ben;  Chambers, Tim;  Nye, Emma;  Graca, Sofia;  Joshi, Kroopa;  Furness, Andrew;  Ben Aissa, Assma;  Wong, Yien Ning Sophia;  Georgiou, Andy;  Quezada, Sergio A.;  Peggs, Karl S.;  Hartley, John A.;  Lowe, Helen L.;  Herrero, Javier;  Lawrence, David;  Hayward, Martin;  Panagiotopoulos, Nikolaos;  Kolvekar, Shyam;  Falzon, Mary;  Borg, Elaine;  Marafioti, Teresa;  Simeon, Celia;  Hector, Gemma;  Smith, Amy;  Aranda, Marie;  Novelli, Marco;  Oukrif, Dahmane;  Akarca, Ayse U.;  Janes, Sam M.;  Thakrar, Ricky;  Forster, Martin D.;  Ahmad, Tanya;  Lee, Siow Ming;  Papadatos-Pastos, Dionysis;  Carnell, Dawn;  Mendes, Ruheena;  George, Jeremy;  Navani, Neal;  Ahmed, Asia;  Taylor, Magali;  Choudhary, Junaid;  Summers, Yvonne;  Califano, Raffaele;  Taylor, Paul;  Shah, Rajesh;  Krysiak, Piotr;  Rammohan, Kendadai;  Fontaine, Eustace;  Booton, Richard;  Evison, Matthew;  Crosbie, Phil A.;  Moss, Stuart;  Idries, Faiza;  Joseph, Leena;  Bishop, Paul;  Chaturvedi, Anshuman;  Quinn, Anne Marie;  Doran, Helen;  Leek, Angela;  Harrison, Phil;  Moore, Katrina;  Waddington, Rachael;  Novasio, Juliette;  Blackhall, Fiona;  Rogan, Jane;  Smith, Elaine;  Dive, Caroline;  Tugwood, Jonathan;  Brady, Ged;  Rothwell, Dominic G.;  Chemi, Francesca;  Pierce, Jackie;  Gulati, Sakshi;  Naidu, Babu;  Langman, Gerald;  Trotter, Simon;  Bellamy, Mary;  Bancroft, Hollie;  Kerr, Amy;  Kadiri, Salma;  Webb, Joanne;  Middleton, Gary;  Djearaman, Madava;  Fennell, Dean A.;  Shaw, Jacqui A.;  Le Quesne, John;  Moore, David A.;  Thomas, Anne;  Walter, Harriet;  Riley, Joan;  Martinson, Luke;  Nakas, Apostolos;  Rathinam, Sridhar;  Monteiro, William;  Marshall, Hilary;  Nelson, Louise;  Bennett, Jonathan;  Primrose, Lindsay;  Anand, Girija;  Khan, Sajid;  Amadi, Anita;  Nicolson, Marianne;  Kerr, Keith;  Palmer, Shirley;  Remmen, Hardy;  Miller, Joy;  Buchan, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Lester, Jason F.;  Edwards, Alison;  Morgan, Fiona;  Adams, Haydn;  Davies, Helen;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Lock, Sara;  Verjee, Azmina;  MacKenzie, Mairead;  Wilcox, Maggie;  Bell, Harriet;  Iles, Natasha;  Hackshaw, Allan;  Ngai, Yenting;  Smith, Sean;  Gower, Nicole;  Ottensmeier, Christian;  Chee, Serena;  Johnson, Benjamin;  Alzetani, Aiman;  Shaw, Emily;  Lim, Eric;  De Sousa, Paulo;  Barbosa, Monica Tavares;  Bowman, Alex;  Jordan, Simon;  Rice, Alexandra;  Raubenheimer, Hilgardt;  Proli, Chiara;  Cufari, Maria Elena;  Ronquillo, John Carlo;  Kwayie, Angela;  Bhayani, Harshil;  Hamilton, Morag;  Bakar, Yusura;  Mensah, Natalie;  Ambrose, Lyn;  Devaraj, Anand;  Buderi, Silviu;  Finch, Jonathan;  Azcarate, Leire;  Chavan, Hema;  Green, Sophie;  Mashinga, Hillaria;  Nicholson, Andrew G.;  Lau, Kelvin;  Sheaff, Michael;  Schmid, Peter;  Conibear, John;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Russell, Peter;  Light, Teresa;  Horey, Tracey;  Danson, Sarah;  Bury, Jonathan;  Edwards, John;  Hill, Jennifer;  Matthews, Sue;  Kitsanta, Yota;  Suvarna, Kim;  Fisher, Patricia;  Keerio, Allah Dino;  Shackcloth, Michael;  Gosney, John;  Postmus, Pieter;  Feeney, Sarah;  Asante-Siaw, Julius;  Constantin, Tudor;  Salari, Raheleh;  Sponer, Nicole;  Naik, Ashwini;  Zimmermann, Bernhard G.;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Dentro, Stefan;  Dessimoz, Christophe
收藏  |  浏览/下载：24/0  |  提交时间：2019/04/09