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Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Mei-Fei Yueh;  Feng He;  Chen Chen;  Catherine Vu;  Anupriya Tripathi;  Rob Knight;  Michael Karin;  Shujuan Chen;  Robert H. Tukey
收藏  |  浏览/下载：6/0  |  提交时间：2020/11/30
Can N2O emissions offset the benefits from soil organic carbon storage? 期刊论文
Global Change Biology, 2020
作者:  Bertrand Guenet;  Benoit Gabrielle;  Claire Chenu;  Dominique Arrouays;  Jé;  rô;  me Balesdent;  Martial Bernoux;  Elisa Bruni;  Jean‐;  Pierre Caliman;  Ré;  mi Cardinael;  Songchao Chen;  Philippe Ciais;  Dominique Desbois;  Julien Fouche;  Stefan Frank;  Catherine Henault;  Emanuele Lugato;  Victoria Naipal;  Thomas Nesme;  Michael Obersteiner;  Sylvain Pellerin;  David S. Powlson;  Daniel P. Rasse;  Fré;  dé;  ric Rees;  Jean‐;  Franç;  ois Soussana;  Yang Su;  Hanqin Tian;  Hugo Valin;  Feng Zhou
收藏  |  浏览/下载：16/0  |  提交时间：2020/10/12
Response to Comment on “Females engaging in adaptive hybridization prefer high-quality heterospecifics as mates” 期刊论文
Science, 2020
作者:  Catherine Chen;  Karin S. Pfennig
收藏  |  浏览/下载：0/0  |  提交时间：2020/10/12
DNA vaccine protection against SARS-CoV-2 in rhesus macaques 期刊论文
Science, 2020
作者:  Jingyou Yu;  Lisa H. Tostanoski;  Lauren Peter;  Noe B. Mercado;  Katherine McMahan;  Shant H. Mahrokhian;  Joseph P. Nkolola;  Jinyan Liu;  Zhenfeng Li;  Abishek Chandrashekar;  David R. Martinez;  Carolin Loos;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Yuezhou Chen;  Adam Zuiani;  Felipe J. N. Lelis;  Meghan Travers;  Shaghayegh Habibi;  Laurent Pessaint;  Alex Van Ry;  Kelvin Blade;  Renita Brown;  Anthony Cook;  Brad Finneyfrock;  Alan Dodson;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Marinela Kirilova;  Nicole Kordana;  Zijin Lin;  Lori F. Maxfield;  Felix Nampanya;  Ramya Nityanandam;  John D. Ventura;  Huahua Wan;  Yongfei Cai;  Bing Chen;  Aaron G. Schmidt;  Duane R. Wesemann;  Ralph S. Baric;  Galit Alter;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载：18/0  |  提交时间：2020/08/18
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator 期刊论文
SCIENCE, 2018, 362 (6421) : 1375-+
作者:  Guo, Ang;  Wang, Yihui;  Chen, Biyi;  Wang, Yunhao;  Yuan, Jinxiang;  Zhang, Liyang;  Hall, Duane;  Wu, Jennifer;  Shi, Yun;  Thu, Qi;  Chen, Cheng;  Thiel, William H.;  Than, Xin;  Weiss, Robert M.;  Zhan, Fenghuang;  Musselman, Catherine A.;  Pufall, Miles;  Zhu, Weizhong;  Au, Kin Fai;  Hong, Jiang;  Anderson, Mark E.;  Grueter, Chad E.;  Song, Long-Sheng
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2018, 126 (6)
作者:  Li, Jun;  Zhu, Xiaoyan;  Yu, Kuai;  Jiang, Haijing;  Zhang, Yizhi;  Wang, Biqi;  Liu, Xuezhen;  Deng, Siyun;  Hu, Jie;  Deng, Qifei;  Sun, Huizhen;  Guo, Huan;  Zhang, Xiaomin;  Chen, Weihong;  Yuan, Jing;  He, Meian;  Bai, Yansen;  Han, Xu;  Liu, Bing;  Liu, Chuanyao;  Guo, Yanjun;  Zhang, Bing;  Zhang, Zhihong;  Hu, Frank B.;  Gao, Wenjing;  Li, Liming;  Lathrop, Mark;  Laprise, Catherine;  Liang, Liming;  Wu, Tanchun
收藏  |  浏览/下载：22/0  |  提交时间：2019/04/09
Regional contribution to variability and trends of global gross primary productivity 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2017, 12 (10)
作者:  Chen, Min;  Rafique, Rashid;  Asrar, Ghassem R.;  Bond-Lamberty, Ben;  Ciais, Philippe;  Zhao, Fang;  Reyer, Christopher P. O.;  Ostberg, Sebastian;  Chang, Jinfeng;  Ito, Akihiko;  Yang, Jia;  Zeng, Ning;  Kalnay, Eugenia;  West, Tristram;  Leng, Guoyong;  Francois, Louis;  Munhoven, Guy;  Henrot, Alexandra;  Tian, Hanqin;  Pan, Shufen;  Nishina, Kazuya;  Viovy, Nicolas;  Morfopoulos, Catherine;  Betts, Richard;  Schaphoff, Sibyll;  Steinkamp, Joerg;  Hickler, Thomas
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/09
gross primary productivity  terrestrial ecosystems  inter-annual variability  seasonal variability  
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Xiao, Shuo;  Coppeta, Jonathan R.;  Rogers, Hunter B.;  Isenberg, Brett C.;  Zhu, Jie;  Olalekan, Susan A.;  McKinnon, Kelly E.;  Dokic, Danijela;  Rashedi, Alexandra S.;  Haisenleder, Daniel J.;  Malpani, Saurabh S.;  Arnold-Murray, Chanel A.;  Chen, Kuanwei;  Jiang, Mingyang;  Bai, Lu;  Nguyen, Catherine T.;  Zhang, Jiyang;  Laronda, Monica M.;  Hope, Thomas J.;  Maniar, Kruti P.;  Pavone, Mary Ellen;  Avram, Michael J.;  Sefton, Elizabeth C.;  Getsios, Spiro;  Burdette, Joanna E.;  Kim, J. Julie;  Borenstein, Jeffrey T.;  Woodruff, Teresa K.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27