Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2773 |
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging | |
Li, Jun1,2,3,4; Zhu, Xiaoyan1,2,5; Yu, Kuai1,2; Jiang, Haijing1,2; Zhang, Yizhi1,2; Wang, Biqi6,7; Liu, Xuezhen1,2; Deng, Siyun1,2; Hu, Jie1,2; Deng, Qifei1,2; Sun, Huizhen1,2; Guo, Huan1,2; Zhang, Xiaomin1,2; Chen, Weihong1,2; Yuan, Jing1,2; He, Meian1,2; Bai, Yansen1,2; Han, Xu1,2; Liu, Bing1,2; Liu, Chuanyao1,2; Guo, Yanjun1,2; Zhang, Bing1,2; Zhang, Zhihong1,2; Hu, Frank B.3,4,8,9; Gao, Wenjing6; Li, Liming; Lathrop, Mark10,11; Laprise, Catherine12,13; Liang, Liming4,14; Wu, Tanchun1,2 | |
2018-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA; Canada |
英文摘要 | BACKGROUND: Aging is related to an increased risk of morbidity and mortality and is affected by environmental factors. Exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse health outcomes; but the association of such exposure with DNA methylation aging, a novel aging marker, is unclear. OBJECTIVES: Our aim was to investigate the association of PAH exposure with methylation aging. METHODS: We trained and validated a methylation age predictor suitable for Chinese populations using whole blood methylation data in 989 Chinese and 160 Caucasians. We defined two aging indicators: Delta age, as methylation age minus chronological age; and aging rate, the ratio of methylation to chronological age. The association of PAH exposure with aging indicators was evaluated using linear regressions in three panels of healthy Chinese participants (N = 539, among the aforementioned 989 Chinese participants) whose exposure levels were assessed by 10 urinary monohydroxy-PAH metabolites. RESULTS: We developed a methylation age predictor providing accurate predictions in both Chinese individuals and Caucasian persons (R = 0.94-0.96, RMSE = 3.8-4.3). Among the 10 urinary metabolites that we measured, 1-hydroxypyrene and 9-hydroxyphenanthrene were associated with methylation aging independently of other OH-PAHs and risk factors; 1-unit increase in 1-hydroxypyrene was associated with a 0.53-y increase in Delta age [95% confidence interval (CI): 0.18, 0.88; false discovery rate (FDR) FDR = 0.004] and 1.17% increase in aging rate (95% CT 0.36, 1.98; EDR = 0.02), whereas for 9-hydroxyphenanthrene, the increase was 0.54-y for Delta age (95% CI: 0.17, 0.91; FDR = 0.004), and 1.15% for aging rate (95% CI: 0.31, 1.99; FDR = 0.02). The association direction was consistent across the three Chinese panels with the association magnitude correlating with the panels' exposure levels; the association was validated by methylation data of purified leukocytes. Several cytosine-phosphoguanines, including those located on FHL2 and ELOVL2, were found associated with both aging indicators and monohydroxy-PAH CONCLUSIONS: We developed a methylation age predictor specific for Chinese populations but also accurate for Caucasian populations. Our findings suggest that exposure to PAHs may he associated with an adverse impact on human aging and epigenetic alterations in Chinese populations. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438820100009 |
WOS关键词 | GENOME-WIDE ANALYSIS ; OXIDATIVE STRESS ; EPIGENETIC CLOCK ; TELOMERE LENGTH ; AGE ; RACE/ETHNICITY ; PIPELINE ; SMOKING ; TARGETS ; CANCER |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23236 |
专题 | 资源环境科学 |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China; 3.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; 4.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 5.Suzhou Ctr Dis Prevent & Control, Suzhou, Jiangshu, Peoples R China; 6.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China; 7.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA; 8.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA; 9.Harvard Med Sch, Boston, MA USA; 10.McGill Univ, Dept Human Genet, Montreal, PQ, Canada; 11.Genome Innovat Ctr, Montreal, PQ, Canada; 12.Univ Quebec Chicoutimi, Dept Fundamental Sci, Chicoutimi, PQ, Canada; 13.Ctr Integre Univ Sante & Serv Sociaux Saguenay La, Saguenay, PQ, Canada; 14.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA |
推荐引用方式 GB/T 7714 | Li, Jun,Zhu, Xiaoyan,Yu, Kuai,et al. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(6). |
APA | Li, Jun.,Zhu, Xiaoyan.,Yu, Kuai.,Jiang, Haijing.,Zhang, Yizhi.,...&Wu, Tanchun.(2018).Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging.ENVIRONMENTAL HEALTH PERSPECTIVES,126(6). |
MLA | Li, Jun,et al."Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging".ENVIRONMENTAL HEALTH PERSPECTIVES 126.6(2018). |
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