Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan3303 |
E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator | |
Guo, Ang1; Wang, Yihui1,2; Chen, Biyi1; Wang, Yunhao1; Yuan, Jinxiang1; Zhang, Liyang3; Hall, Duane1; Wu, Jennifer1; Shi, Yun1; Thu, Qi1,4; Chen, Cheng1,2; Thiel, William H.1; Than, Xin1; Weiss, Robert M.1; Zhan, Fenghuang1; Musselman, Catherine A.3; Pufall, Miles3; Zhu, Weizhong4; Au, Kin Fai1,8; Hong, Jiang2; Anderson, Mark E.5; Grueter, Chad E.1,6; Song, Long-Sheng1,6,7 | |
2018-12-21 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6421页码:1375-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 is cleaved by the calcium ion dependent protease calpain, which disrupts the E-C coupling ultrastructural machinery and drives heart failure progression. We found that stress-induced proteolysis of JP2 liberates an N-terminal fragment (JP2NT) that translocates to the nucleus, binds to genomic DNA, and controls expression of a spectrum of genes in cardiomyocytes. Transgenic overexpression of JP2NT in mice modifies the transcriptional profile, resulting in attenuated pathological remodeling in response to cardiac stress. Conversely, loss of nuclear JP2NT function accelerates stress-induced development of hypertrophy and heart failure in mutant mice. These data reveal a self-protective mechanism in failing cardiomyocytes that transduce mechanical information (E-C uncoupling) into salutary transcriptional reprogramming in the stressed heart. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000453845000049 |
WOS关键词 | CARDIAC-HYPERTROPHY ; RYANODINE RECEPTORS ; CALPAIN ; GROWTH ; MEMBRANE ; CHANNELS ; RELEASE ; SIGNALS ; SPARKS ; MEF2 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200379 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Iowa, Carver Coll Med, Abboud Cardiovasc Res Ctr, Dept Internal Med, Iowa City, IA 52242 USA; 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Emergency Med, Shanghai 200080, Peoples R China; 3.Univ Iowa, Carver Coll Med, Dept Biochem, Iowa City, IA 52242 USA; 4.Nantong Univ, Sch Pharm, Dept Pharmacol, Nantong 226001, Jiangsu, Peoples R China; 5.Johns Hopkins Sch Med, Dept Med, Baltimore, MD 21205 USA; 6.Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA; 7.Iowa City Vet Affairs Med Ctr, Iowa City, IA 52242 USA; 8.Ohio State Univ, Dept Biomed Informat, Columbus, OH 43210 USA |
推荐引用方式 GB/T 7714 | Guo, Ang,Wang, Yihui,Chen, Biyi,et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator[J]. SCIENCE,2018,362(6421):1375-+. |
APA | Guo, Ang.,Wang, Yihui.,Chen, Biyi.,Wang, Yunhao.,Yuan, Jinxiang.,...&Song, Long-Sheng.(2018).E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator.SCIENCE,362(6421),1375-+. |
MLA | Guo, Ang,et al."E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator".SCIENCE 362.6421(2018):1375-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论