中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共32条，第1-10条 帮助

限定条件                
已选(0)清除 条数/页：   排序方式：
Incorporating of Fish Tolerance to Supersaturated Total Dissolved Gas for Generating Flood Pulse Discharge Patterns Based on a Simulation-Optimization Approach 期刊论文
Water Resources Research, 2021
作者:  H. Wan;  Q. Tan;  R. Li;  Y. Cai;  X. Shen;  Z. Yang;  X. Shen
收藏  |  浏览/下载：19/0  |  提交时间：2021/08/25
A new hydrologic sensitivity framework of unsteady-state responses to climate change and its application to catchments with croplands in Illinois 期刊论文
Water Resources Research, 2021
作者:  Peng-Fei Han;  Erkan Istanbulluoglu;  Li Wan;  Xu-Sheng Wang
收藏  |  浏览/下载：14/0  |  提交时间：2021/08/10
Plant “helper” immune receptors are Ca2+-permeable nonselective cation channels 期刊论文
Science, 2021
作者:  Pierre Jacob;  Nak Hyun Kim;  Feihua Wu;  Farid El-Kasmi;  Yuan Chi;  William G. Walton;  Oliver J. Furzer;  Adam D. Lietzan;  Sruthi Sunil;  Korina Kempthorn;  Matthew R. Redinbo;  Zhen-Ming Pei;  Li Wan;  Jeffery L. Dangl
收藏  |  浏览/下载：15/0  |  提交时间：2021/07/27
Perceptions of the appropriate response to norm violation in 57 societies 期刊论文
Nature Communications, 2021
作者:  Kimmo Eriksson;  Pontus Strimling;  Michele Gelfand;  Junhui Wu;  Jered Abernathy;  Charity S. Akotia;  Alisher Aldashev;  Per A. Andersson;  Giulia Andrighetto;  Adote Anum;  Gizem Arikan;  Zeynep Aycan;  Fatemeh Bagherian;  Davide Barrera;  Dana Basnight-Brown;  Birzhan Batkeyev;  Anabel Belaus;  Elizaveta Berezina;  Marie Bjö;  rnstjerna;  Sheyla Blumen;  Paweł;  Boski;  Fouad Bou Zeineddine;  Inna Bovina;  Bui Thi Thu Huyen;  Juan-Camilo Cardenas;  Đ;  orđ;  e Č;  ekrlija;  Hoon-Seok Choi;  Carlos C. Contreras-Ibá;  ñ;  ez;  Rui Costa-Lopes;  Mí;  cheá;  l de Barra;  Piyanjali de Zoysa;  Angela Dorrough;  Nikolay Dvoryanchikov;  Anja Eller;  Jan B. Engelmann;  Hyun Euh;  Xia Fang;  Susann Fiedler;  Olivia A. Foster-Gimbel;  Má;  rta Fü;  lö;  p;  Ragna B. Gardarsdottir;  C. M. Hew D. Gill;  Andreas Glö;  ckner;  Sylvie Graf;  Ani Grigoryan;  Vladimir Gritskov;  Katarzyna Growiec;  Peter Halama;  Andree Hartanto;  Tim Hopthrow;  Martina Hř;  ebí;  č;  ková;  Dzintra Iliš;  ko;  Hirotaka Imada;  Hansika Kapoor;  Kerry Kawakami;  Narine Khachatryan;  Natalia Kharchenko;  Ninetta Khoury;  Toko Kiyonari;  Michal Kohú;  t;  Lê;  Thuỳ;  Linh;  Lisa M. Leslie;  Yang Li;  Norman P. Li;  Zhuo Li;  Kadi Liik;  Angela T. Maitner;  Bernardo Manhique;  Harry Manley;  Imed Medhioub;  Sari Mentser;  Linda Mohammed;  Pegah Nejat;  Orlando Nipassa;  Ravit Nussinson;  Nneoma G. Onyedire;  Ike E. Onyishi;  Seniha Ö;  zden;  Penny Panagiotopoulou;  Lorena R. Perez-Floriano;  Minna S. Persson;  Mpho Pheko;  Anna-Maija Pirttilä;  -Backman;  Marianna Pogosyan;  Jana Raver;  Cecilia Reyna;  Ricardo Borges Rodrigues;  Sara Romanò;  Pedro P. Romero;  Inari Sakki;  Alvaro San Martin;  Sara Sherbaji;  Hiroshi Shimizu;  Brent Simpson;  Erna Szabo;  Kosuke Takemura;  Hassan Tieffi;  Maria Luisa Mendes Teixeira;  Napoj Thanomkul;  Habib Tiliouine;  Giovanni A. Travaglino;  Yannis Tsirbas;  Richard Wan;  Sita Widodo;  Rizqy Zein;  Qing-peng Zhang;  Lina Zirganou-Kazolea;  Paul A. M. Van Lange
收藏  |  浏览/下载：13/0  |  提交时间：2021/03/12
Black phosphorus composites with engineered interfaces for high-rate high-capacity lithium storage 期刊论文
Science, 2020
作者:  Hongchang Jin;  Sen Xin;  Chenghao Chuang;  Wangda Li;  Haiyun Wang;  Jian Zhu;  Huanyu Xie;  Taiming Zhang;  Yangyang Wan;  Zhikai Qi;  Wensheng Yan;  Ying-Rui Lu;  Ting-Shan Chan;  Xiaojun Wu;  John B. Goodenough;  Hengxing Ji;  Xiangfeng Duan
收藏  |  浏览/下载：14/0  |  提交时间：2020/10/12
Arctic sea-ice loss intensifies aerosol transport to the Tibetan Plateau 期刊论文
Nature, 2020
作者:  Fei Li;  Xin Wan;  Huijun Wang;  Yvan Joseph Orsolini;  Zhiyuan Cong;  Yongqi Gao;  Shichang Kang
收藏  |  浏览/下载：14/0  |  提交时间：2020/09/08
DNA vaccine protection against SARS-CoV-2 in rhesus macaques 期刊论文
Science, 2020
作者:  Jingyou Yu;  Lisa H. Tostanoski;  Lauren Peter;  Noe B. Mercado;  Katherine McMahan;  Shant H. Mahrokhian;  Joseph P. Nkolola;  Jinyan Liu;  Zhenfeng Li;  Abishek Chandrashekar;  David R. Martinez;  Carolin Loos;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Yuezhou Chen;  Adam Zuiani;  Felipe J. N. Lelis;  Meghan Travers;  Shaghayegh Habibi;  Laurent Pessaint;  Alex Van Ry;  Kelvin Blade;  Renita Brown;  Anthony Cook;  Brad Finneyfrock;  Alan Dodson;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Marinela Kirilova;  Nicole Kordana;  Zijin Lin;  Lori F. Maxfield;  Felix Nampanya;  Ramya Nityanandam;  John D. Ventura;  Huahua Wan;  Yongfei Cai;  Bing Chen;  Aaron G. Schmidt;  Duane R. Wesemann;  Ralph S. Baric;  Galit Alter;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载：18/0  |  提交时间：2020/08/18
Impacts of international trade on global sustainable development 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Xu, Zhenci;  Li, Yingjie;  Chau, Sophia N.;  Dietz, Thomas;  Li, Canbing;  Wan, Luwen;  Zhang, Jindong;  Zhang, Liwei;  Li, Yunkai;  Chung, Min Gon;  Liu, Jianguo
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/21
Chloride-mediated selective electrosynthesis of ethylene and propylene oxides at high current density 期刊论文
Science, 2020
作者:  Wan Ru Leow;  Yanwei Lum;  Adnan Ozden;  Yuhang Wang;  Dae-Hyun Nam;  Bin Chen;  Joshua Wicks;  Tao-Tao Zhuang;  Fengwang Li;  David Sinton;  Edward H. Sargent
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/16
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.