Plant “helper” immune receptors are Ca<sup>2+</sup>-permeable nonselective cation channels

doi:10.1126/science.abg7917

GSTDTAP > 气候变化

DOI	10.1126/science.abg7917
	Plant “helper” immune receptors are Ca²⁺-permeable nonselective cation channels
	Pierre Jacob; Nak Hyun Kim; Feihua Wu; Farid El-Kasmi; Yuan Chi; William G. Walton; Oliver J. Furzer; Adam D. Lietzan; Sruthi Sunil; Korina Kempthorn; Matthew R. Redinbo; Zhen-Ming Pei; Li Wan; Jeffery L. Dangl
	2021-07-23
发表期刊	Science
出版年	2021
英文摘要	In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors (known as TNLs) function in plants as immune receptors. These TNLs work together with a dedicated set of helper proteins. Jacob et al. reveal the structure of one of these helpers known as NRG1 (N REQUIREMENT GENE 1). The structure resembles a known animal cation channel. The authors demonstrate that helper NLRs directly control calcium ion influx to initiate host cell death, providing a mechanism for TNL outputs. Science , abg7917, this issue p. [420][1] Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In Arabidopsis , a subfamily of “helper” NLRs is required by many “sensor” NLRs. Active NRG1.1 oligomerized, was enriched in plasma membrane puncta, and conferred cytoplasmic calcium ion (Ca2+) influx in plant and human cells. NRG1.1-dependent Ca2+ influx and cell death were sensitive to Ca2+ channel blockers and were suppressed by mutations affecting oligomerization or plasma membrane enrichment. Ca2+ influx and cell death mediated by NRG1.1 and ACTIVATED DISEASE RESISTANCE 1 (ADR1), another helper NLR, required conserved negatively charged N-terminal residues. Whole-cell voltage-clamp recordings demonstrated that Arabidopsis helper NLRs form Ca2+-permeable cation channels to directly regulate cytoplasmic Ca2+ levels and consequent cell death. Thus, helper NLRs transduce cell death signals directly. [1]: /lookup/doi/10.1126/science.abg7917
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/334481
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Pierre Jacob,Nak Hyun Kim,Feihua Wu,等. Plant “helper” immune receptors are Ca²⁺-permeable nonselective cation channels[J]. Science,2021.
APA	Pierre Jacob.,Nak Hyun Kim.,Feihua Wu.,Farid El-Kasmi.,Yuan Chi.,...&Jeffery L. Dangl.(2021).Plant “helper” immune receptors are Ca²⁺-permeable nonselective cation channels.Science.
MLA	Pierre Jacob,et al."Plant “helper” immune receptors are Ca²⁺-permeable nonselective cation channels".Science (2021).