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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling 期刊论文
Science, 2021
作者:  Evan W. Weber;  Kevin R. Parker;  Elena Sotillo;  Rachel C. Lynn;  Hima Anbunathan;  John Lattin;  Zinaida Good;  Julia A. Belk;  Bence Daniel;  Dorota Klysz;  Meena Malipatlolla;  Peng Xu;  Malek Bashti;  Sabine Heitzeneder;  Louai Labanieh;  Panayiotis Vandris;  Robbie G. Majzner;  Yanyan Qi;  Katalin Sandor;  Ling-Chun Chen;  Snehit Prabhu;  Andrew J. Gentles;  Thomas J. Wandless;  Ansuman T. Satpathy;  Howard Y. Chang;  Crystal L. Mackall
收藏  |  浏览/下载:16/0  |  提交时间:2021/04/06
Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy 期刊论文
Science, 2020
作者:  Boyang Qin;  Chenyi Fei;  Andrew A. Bridges;  Ameya A. Mashruwala;  Howard A. Stone;  Ned S. Wingreen;  Bonnie L. Bassler
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/06
Monumental architecture at Aguada Fenix and the rise of Maya civilization 期刊论文
NATURE, 2020
作者:  Bedding, Timothy R.;  Murphy, Simon J.;  Hey, Daniel R.;  Huber, Daniel;  Li, Tanda;  Smalley, Barry;  Stello, Dennis;  White, Timothy R.;  Ball, Warrick H.;  Chaplin, William J.;  Colman, Isabel L.;  Fuller, Jim;  Gaidos, Eric;  Harbeck, Daniel R.;  Hermes, J. J.;  Holdsworth, Daniel L.;  Li, Gang;  Li, Yaguang;  Mann, Andrew W.;  Reese, Daniel R.;  Sekaran, Sanjay;  Yu, Jie;  Antoci, Victoria;  Bergmann, Christoph;  Brown, Timothy M.;  Howard, Andrew W.;  Ireland, Michael J.;  Isaacson, Howard;  Jenkins, Jon M.;  Kjeldsen, Hans;  McCully, Curtis;  Rabus, Markus;  Rains, Adam D.;  Ricker, George R.;  Tinney, Christopher G.;  Vanderspek, Roland K.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

Archaeologists have traditionally thought that the development of Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclassic period (1000-350 bc  dates are calibrated throughout) along with the use of ceramics and the adoption of sedentism(1). Recent finds of early ceremonial complexes are beginning to challenge this model. Here we describe an airborne lidar survey and excavations of the previously unknown site of Aguada Fenix (Tabasco, Mexico) with an artificial plateau, which measures 1,400 m in length and 10 to 15 m in height and has 9 causeways radiating out from it. We dated this construction to between 1000 and 800 bc using a Bayesian analysis of radiocarbon dates. To our knowledge, this is the oldest monumental construction ever found in the Maya area and the largest in the entire pre-Hispanic history of the region. Although the site exhibits some similarities to the earlier Olmec centre of San Lorenzo, the community of Aguada Fenix probably did not have marked social inequality comparable to that of San Lorenzo. Aguada Fenix and other ceremonial complexes of the same period suggest the importance of communal work in the initial development of Maya civilization.


Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fenix, which dates to around 1000-800 bc and points to the role of communal construction in the development of Maya civilization.


  
Complexity revealed in the greening of the Arctic 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (2) : 106-117
作者:  Myers-Smith, Isla H.;  Kerby, Jeffrey T.;  Phoenix, Gareth K.;  Bjerke, Jarle W.;  Epstein, Howard E.;  Assmann, Jakob J.;  John, Christian;  Andreu-Hayles, Laia;  Angers-Blondin, Sandra;  Beck, Pieter S. A.;  Berner, Logan T.;  Bhatt, Uma S.;  Bjorkman, Anne D.;  Blok, Daan;  Bryn, Anders;  Christiansen, Casper T.;  Cornelissen, J. Hans C.;  Cunliffe, Andrew M.;  Elmendorf, Sarah C.;  Forbes, Bruce C.;  Goetz, Scott J.;  Hollister, Robert D.;  de Jong, Rogier;  Loranty, Michael M.;  Macias-Fauria, Marc;  Maseyk, Kadmiel;  Normand, Signe;  Olofsson, Johan;  Parker, Thomas C.;  Parmentier, Frans-Jan W.;  Post, Eric;  Schaepman-Strub, Gabriela;  Stordal, Frode;  Sullivan, Patrick F.;  Thomas, Haydn J. D.;  Tommervik, Hans;  Treharne, Rachael;  Tweedie, Craig E.;  Walker, Donald A.;  Wilmking, Martin;  Wipf, Sonja
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/13
Double counting and the Paris Agreement rulebook 期刊论文
SCIENCE, 2019, 366 (6462) : 180-183
作者:  Schneider, Lambert;  Duan, Maosheng;  Stavins, Robert;  Kizzier, Kelley;  Broekhoff, Derik;  Jotzo, Frank;  Winkler, Harald;  Lazarus, Michael;  Howard, Andrew;  Hood, Christina
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis 期刊论文
SCIENCE, 2019, 365 (6451) : 386-+
作者:  Chaurasia, Bhagirath;  Tippetts, Trevor S.;  Monibas, Rafael Mayoral;  Liu, Jinqi;  Li, Ying;  Wang, Liping;  Wilkerson, Joseph L.;  Sweeney, C. Rufus;  Pereira, Renato Felipe;  Sumida, Doris Hissako;  Maschek, J. Alan;  Cox, James E.;  Kaddai, Vincent;  Lancaster, Graeme Iain;  Siddique, Monowarul Mobin;  Poss, Annelise;  Pearson, Mackenzie;  Satapati, Santhosh;  Zhou, Heather;  McLaren, David G.;  Previs, Stephen F.;  Chen, Ying;  Qian, Ying;  Petrov, Aleksandr;  Wu, Margaret;  Shen, Xiaolan;  Yao, Jun;  Nunes, Christian N.;  Howard, Andrew D.;  Wang, Liangsu;  Erion, Mark D.;  Rutter, Jared;  Holland, William L.;  Kelley, David E.;  Summers, Scott A.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Numerical ordering of zero in honey bees 期刊论文
SCIENCE, 2018, 360 (6393) : 1124-+
作者:  Howard, Scarlett R.;  Avargues-Weber, Aurore;  Garcia, Jair E.;  Greentree, Andrew D.;  Dyer, Adrian G.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
An anatomic transcriptional atlas of human glioblastoma 期刊论文
SCIENCE, 2018, 360 (6389) : 660-663
作者:  Puchalski, Ralph B.;  Shah, Nameeta;  Miller, Jeremy;  Dalley, Rachel;  Nomura, Steve R.;  Yoon, Jae-Guen;  Smith, Kimberly A.;  Lankerovich, Michael;  Bertagnolli, Darren;  Bickley, Kris;  Boe, Andrew F.;  Brouner, Krissy;  Butler, Stephanie;  Caldejon, Shiella;  Chapin, Mike;  Datta, Suvro;  Dee, Nick;  Desta, Tsega;  Dolbeare, Tim;  Dotson, Nadezhda;  Ebbert, Amanda;  Feng, David;  Feng, Xu;  Fisher, Michael;  Gee, Garrett;  Goldy, Jeff;  Gourley, Lindsey;  Gregor, Benjamin W.;  Gu, Guangyu;  Hejazinia, Nika;  Hohmann, John;  Hothi, Parvinder;  Howard, Robert;  Joines, Kevin;  Kriedberg, Ali;  Kuan, Leonard;  Lau, Chris;  Lee, Felix;  Lee, Hwahyung;  Lemon, Tracy;  Long, Fuhui;  Mastan, Naveed;  Mott, Erika;  Murthy, Chantal;  Ngo, Kiet;  Olson, Eric;  Reding, Melissa;  Riley, Zack;  Rosen, David;  Sandman, David;  Shapovalova, Nadiya;  Slaughterbeck, Clifford R.;  Sodt, Andrew;  Stockdale, Graham;  Szafer, Aaron;  Wakeman, Wayne;  Wohnoutka, Paul E.;  White, Steven J.;  Marsh, Don;  Rostomily, Robert C.;  Ng, Lydia;  Dang, Chinh;  Jones, Allan;  Keogh, Bart;  Gittleman, Haley R.;  Barnholtz-Sloan, Jill S.;  Cimino, Patrick J.;  Uppin, Megha S.;  Keene, C. Dirk;  Farrokhi, Farrokh R.;  Lathia, Justin D.;  Berens, Michael E.;  Iavarone, Antonio;  Bernard, Amy;  Lein, Ed;  Phillips, John W.;  Rostad, Steven W.;  Cobbs, Charles;  Hawrylycz, Michael J.;  Foltz, Greg D.
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
Climate change is predicted to alter the current pest status of Globodera pallida and G.rostochiensis in the United Kingdom 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Jones, Laura M.;  Koehler, Ann-Kristin;  Trnka, Mirek;  Balek, Jan;  Challinor, Andrew J.;  Atkinson, Howard J.;  Urwin, Peter E.
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
climate change  Globodera pallida  Globodera rostochiensis  plant pathogens  potato cyst nematode  soil temperature simulations  soil-borne pests  
Time-series Analysis of Heat Waves and Emergency Department Visits in Atlanta, 1993 to 2012 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2017, 125 (5)
作者:  Chen, Tianqi;  Sarnat, Stefanie E.;  Grundstein, Andrew J.;  Winquist, Andrea;  Chang, Howard H.
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09