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A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Multiple early-formed water reservoirs in the interior of Mars 期刊论文
NATURE GEOSCIENCE, 2020, 13 (4) : 260-+
作者:  Barnes, Jessica J.;  McCubbin, Francis M.;  Santos, Alison R.;  Day, James M. D.;  Boyce, Jeremy W.;  Schwenzer, Susanne P.;  Ott, Ulrich;  Franchi, Ian A.;  Messenger, Scott;  Anand, Mahesh;  Agee, Carl B.
收藏  |  浏览/下载:6/0  |  提交时间:2020/05/13
Comment on "Global pattern of nest predation is disrupted by climate change in shorebirds" 期刊论文
SCIENCE, 2019, 364 (6445) : 1041-+
作者:  Bulla, Martin;  Reneerkens, Jeroen;  Weiser, Emily L.;  Sokolov, Aleksandr;  Taylor, Audrey R.;  Sittler, Benoit;  McCaffery, Brian J.;  Ruthrauff, Dan R.;  Catlin, Daniel H.;  Payer, David C.;  Ward, David H.;  Solovyeva, Diana V.;  Santos, Eduardo S. A.;  Rakhimberdiev, Eldar;  Nol, Erica;  Kwon, Eunbi;  Brown, Glen S.;  Hevia, Glenda D.;  etc
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Observation of two-neutrino double electron capture in Xe-124 with XENON1T 期刊论文
NATURE, 2019, 568 (7753) : 532-+
作者:  Aprile, E.;  Aalbers, J.;  Agostini, F.;  Alfonsi, M.;  Althueser, L.;  Amaro, F. D.;  Anthony, M.;  Antochi, V. C.;  Arneodo, F.;  Baudis, L.;  Bauermeister, B.;  Benabderrahmane, L.;  Berger, T.;  Breur, P. A.;  Brown, A.;  Brown, A.;  Brown, E.;  Bruenner, S.;  Bruno, G.;  Budnik, R.;  Capelli, C.;  Cardoso, J. M. R.;  Cichon, D.;  Coderre, D.;  Colijn, A. P.;  Conrad, J.;  Cussonneau, J. P.;  Decowski, M. P.;  de Perio, P.;  Di Gangi, P.;  Di Giovanni, A.;  Diglio, S.;  Elykov, A.;  Eurin, G.;  Fei, J.;  Ferella, A. D.;  Fieguth, A.;  Fulgione, W.;  Rosso, A. Gallo;  Galloway, M.;  Gao, F.;  Garbini, M.;  Grandi, L.;  Greene, Z.;  Hasterok, C.;  Hogenbirk, E.;  Howlett, J.;  Iacovacci, M.;  Itay, R.;  Joerg, F.;  Kaminsky, B.;  Kazama, S.;  Kish, A.;  Koltman, G.;  Kopec, A.;  Landsman, H.;  Lang, R. F.;  Levinson, L.;  Lin, Q.;  Lindemann, S.;  Lindner, M.;  Lombardi, F.;  Lopes, J. A. M.;  Fune, E. Lopez;  Macolino, C.;  Mahlstedt, J.;  Manfredini, A.;  Marignetti, F.;  Undagoitia, T. Marrodan;  Masbou, J.;  Masson, D.;  Mastroianni, S.;  Messina, M.;  Micheneau, K.;  Miller, K.;  Molinario, A.;  Mora, K.;  Murra, M.;  Naganoma, J.;  Ni, K.;  Oberlack, U.;  Odgers, K.;  Pelssers, B.;  Peres, R.;  Piastra, F.;  Pienaar, J.;  Pizzella, V.;  Plante, G.;  Podviianiuk, R.;  Priel, N.;  Qiu, H.;  Garcia, D. Ramirez;  Reichard, S.;  Riedel, B.;  Rizzo, A.;  Rocchetti, A.;  Rupp, N.;  dos Santos, J. M. F.;  Sartorelli, G.;  Sarcevic, N.;  Scheibelhut, M.;  Schindler, S.;  Schreiner, J.;  Schulte, D.;  Schumann, M.;  Lavina, L. Scotto;  Selvi, M.;  Shagin, P.;  Shockley, E.;  Silva, M.;  Simgen, H.;  Therreau, C.;  Thers, D.;  Toschi, F.;  Trinchero, G.;  Tunnell, C.;  Upole, N.;  Vargas, M.;  Wack, O.;  Wang, H.;  Wang, Z.;  Wei, Y.;  Weinheimer, C.;  Wenz, D.;  Wittweg, C.;  Wulf, J.;  Ye, J.;  Zhang, Y.;  Zhu, T.;  Zopounidis, J. P.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Empowering Latina scientists 期刊论文
SCIENCE, 2019, 363 (6429) : 825-826
作者:  Bernal, Ximena E.;  Rojas, Bibiana;  Pinto-E, Maria Alejandra;  Mendoza-Henao, Angela M.;  Herrera-Montes, Adriana;  Isabel Herrera-Montes, Maria;  Caceres Franco, Andrea del Pilar;  Ceron-Souza, Ivania;  Paz, Andrea;  Vergara, Daniela;  Barragan Contreras, Leidy Alejandra;  Salazar, Camilo;  Bohorquez Alonso, Martha Lucia;  Guarnizo, Carlos E.;  Sanchez, Adriana;  Olaya-Castro, Alexandra;  Urbina-Cardona, Nicolas;  Guayasamin, Juan M.;  Uy, Floria Mora-Kepfer;  Feris, Faride Lamadrid;  Franco-Orozco, Barbara;  Munoz, Martha M.;  Patricia Rincon-Diaz, Martha;  Sanchez Herrera, Melissa;  Betancourth-Cundar, Mileidy;  Tarvin, Rebecca D.;  Marquez, Roberto;  Lopez-Aguirre, Camilo;  Ron, Santiago R.;  Ramirez, Santiago;  Paez-Vacas, Monica;  Gaitan-Espitia, Juan Diego;  Navarrete-Mendez, Maria J.;  Vianna, Juliana A.;  Varela-Jaramillo, Andrea;  Sanchez-Martinez, Paola M.;  Caminer Rodriguez, Marcel Adrian;  Garcia-Robledo, Carlos;  Kuprewicz, Erin K.;  Gomez-Bahamon, Valentina;  Chacon-Vargas, Katherine;  Trillo, Alex;  Ramirez Castaneda, Valeria;  Buenaventura, Eliana;  Carolina Monmany-Garzia, A.;  Carolina Carnaval, Ana;  Dick, Christopher W.;  Jose Andrade-Nunez, Maria;  Carvajal Castro, Juan David;  Marcela Pinto, Diana;  Camargo-Sanabria, Angela A.;  Lips, Karen R.;  Motta-Gonzalez, Diana;  Canedo, Clarissa;  Melissa Diaz, Jhandra;  Navarro-Suarez, Adriana M.;  Corredor, Karen;  Roa-Varon, Adela;  Flechas, Sandra V.;  Andres Martinez-Lanfranco, Juan;  Chiarioni Thome, Maria Tereza;  Caldwell, Michael S.;  Ballestas, Onil;  Mejia M, Carolina;  Chaverri, Gloriana;  Rossi, Alejandra;  Bonaccorso, Elisa;  Pimiento, Catalina;  Guerrero, Rafael F.;  Warkentin, Karen M.;  Montoya-Pachongo, Carolina;  Alvarez, Silvia J.;  Gonzalez-Duran, Gustavo;  Anganoy-Criollo, Marvin;  Martinez-Habibe, Maria Cristina;  Ramirez, Juan P.;  Burrowes, Patricia;  Catenazzi, Alessandro;  Riveros, Andre J.;  Targino, Mariane;  Velez, Alejandro;  Vargas, Oscar M.;  Zapata, Felipe;  Waltrick, Camilla Spengler;  Ceron, Karoline;  Segovia Salcedo, Claudia;  Silva-Velasco, Martha;  Ochoa-Herrera, Valeria;  Medina, Iliana;  Narins, Peter M.;  Alves Saccol, Suelen da Silva;  de Castro Godinho, Marcela Brasil;  Velasquez Escobar, Beatriz Eugenia;  Velasco, Julian A.;  Lomascolo, Silvia;  Hoke, Kim;  Zeidemann, Vivian;  Almeida-Santos, Patricia;  Paola Ferraro, Daiana;  Araujo-Vieira, Katyuscia;  da Rocha, Sabine Borges;  Torres, Maria Fernanda;  Daniel Cadena, Carlos;  Collevatti, Rosane Garcia;  Vasconcellos, Mariana Mira;  Recart, Wilnelia;  Mitchell Aide, T.;  Bacon, Christine;  Jeckel, Adriana Moriguchi;  Diele-Viegas, Luisa Maria;  Calijorne Lourenco, Ana Carolina;  Santos, Danusy Lopes;  Rieder Cholak, Luiza;  Mendes, Roberta Graboski;  Silva, Fernanda Magalhaes;  Guedes, Thais;  Lopez-Perilla, Yeny R.;  Fusinatto, Luciana Ardenghi;  Terra, Juliana de Souza;  Rodriguez Brenes, Sofia;  Narvaez, Andrea E.;  Zina, Juliana;  Calderon-Espinosa, Martha L.;  Pardo-Diaz, Carolina;  Abadie, Michelle;  Maldonado-Chaparro, Adriana;  Cespedes Arias, Laura N.;  Montesinos, Rachel;  Fenker, Jessica;  Brunes, Tuliana Oliveira;  Ferreira Lantyer Silva, Amanda Santiago;  Vallejos, Johana Goyes;  Costa Rodrigues, Ana Paula V.;  Friol, Natalia Rizzo;  Herrera-Alvarez, Santiago;  de Souza, Eletra;  Araujo, Olivia G. S.;  Citeli, Nathalie Q. K.;  Ruggeri, Joice;  Fierro-Calderon, Eliana;  Acevedo-Charry, Orlando;  Barato, Paola;  Campos-Cerqueira, Marconi;  Mazzini, Flavia;  Beltran, Ivan;  Alejandra Meneses-Giorgi, Maria;  Jerez, Adriana;  Clavijo, Andrea P.;  Neira Jimenez, Carolina;  Dantas, Gisele P. M.;  Nascimento, Luciana Barreto;  Caballero, Susana J.;  Henao Sepulveda, A. Carolina;  Wolff, Marta;  Barnabe, Paula Cristina;  Quinones-Lebron, Shakira G.;  Bressan, Raissa Fries;  Gomez-Montoya, Nataly;  Gomez, Camila;  Colon-Pineiro, Zuania;  Esquivel Dobles, Carolina;  Bloch, Natasha;  Stynoski, Jennifer L.;  Arango, Daniel;  Marisol Gonzalez, Tania;  Luque Moreno, Francisco;  Taylor, Ryan;  Lawrence, J. P.;  Briscoe, Adriana Darielle Mejia;  Ortiz-Barrientos, Daniel;  Elena Salerno, Patricia;  Restrepo, Silvia;  Pasukonis, Andrius;  Damasceno, Roberta Pacheco;  Cecilia Dalton, Maria;  Proehl, Heike;  Valdez-Ward, Evelyn;  Andrea Rodriguez, Sabrina;  Marquez Garcia, Marcela;  Bianca Bonaparte, Eugenia;  Molina Escobar, Jorge Alberto;  Brown, Jason L.;  Yeager, Justin;  Kikuchi, David;  Ringler, Max;  Duran, Linda Hernandez;  Schulte, Lisa M.;  Vaira, Marcos;  Pereyra, Laura;  Astudillo Bravo, Diana;  Jose Salica, Maria;  Varga, Sandra;  Eguren, Antonieta;  Grattarola, Florencia;  Bernal, Moises A.;  Soledad Gaston, Maria;  Ortega Chinchilla, Jesus Eduardo;  Burdfield-Steel, Emily;  Valencia, Lina M.;  Ringler, Eva;  Rada, Marco;  Melendez-Ackerman, Elvia;  Botero, Carlos A.;  Estrada-Villegas, Sergio;  Orizaola, German;  Pinto, Brendan J.;  Gonzalez-Bellido, Paloma;  Hunter, Kimberly L.;  Rueda Solano, Luis Alberto;  Gordon, Swanne;  Guerra, Monica A.;  Jose Albo, Maria;  Vega-Frutis, Rocio;  Blundo, Cecilia;  Castaneda-Gomez, Laura;  Donnelly, Maureen A.;  Escobar, Betsabe D. Castro;  Isabel Moreno, Maria;  Crawford, Andrew J.;  Jiggins, Chris D.;  Roessler, Daniela C.;  Bravo Valencia, Laura;  Sarmiento, Carolina;  Munoz, Karen A.;  Galeano, Sandra P.;  del Rosario Castaneda, Maria;  Caro Cardenas, Cindy Jeanet;  Zalamea, Paul-Camilo;  Arias, Monica;  Zank, Caroline;  Suarez-Mayorga, Angela M.;  Colombo, Patrick;  Cuervo, Andres M.;  Coriolano, Iara Reinaldo;  de Melo, Lilian Sayuri Ouchi;  Buitrago Cardona, Alexandra;  Elias, Marianne;  Gonzalez, Mabel;  Maria Aldana, Ana;  Gubert, Carolina;  Luis Parra, Juan;  Contador, Tamara;  Coelho, Lorena;  Trillo, Mariana;  Bordin, Kauane;  Zulian, Viviane;  Moreno Arias, Rafael;  Loretto, Matthias-Claudio;  Alejandra Medina, Claudia;  Lyra, Mariana L.;  Pulido-Santacruz, Paola;  Rosser, Neil;  Waldron, Talia;  Moreno Duran, Carmen Helena;  Pizano, Camila;  Hoedl, Walter;  Fratani, Jessica;  Duport Bru, Ana Sofia;  Grosso, Jimena;  Vera Candioti, Florencia;  Adarve Rengifo, Isabel
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27
The multiple merger assembly of a hyperluminous obscured quasar at redshift 4.6 期刊论文
SCIENCE, 2018, 362 (6418) : 1034-+
作者:  Diaz-Santos, T.;  Assef, R. J.;  Blain, A. W.;  Aravena, M.;  Stern, D.;  Tsai, C. -W.;  Eisenhardt, P.;  Wu, J.;  Jun, H. D.;  Dibert, K.;  Inami, H.;  Lansbury, G.;  Leclercq, F.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Genomic and epidemiological monitoring of yellow fever virus transmission potential 期刊论文
SCIENCE, 2018, 361 (6405) : 894-+
作者:  Faria, N. R.;  Kraemer, M. U. G.;  Hill, S. C.;  de Jesus, J. Goes;  Aguiar, R. S.;  Iani, F. C. M.;  Xavier, J.;  Quick, J.;  du Plessis, L.;  Dellicour, S.;  Theze, J.;  Carvalho, R. D. O.;  Baele, G.;  Wu, C. -H.;  Silveira, P. P.;  Arruda, M. B.;  Pereira, M. A.;  Pereira, G. C.;  Lourenco, J.;  Obolski, U.;  Abade, L.;  Vasylyeva, T. I.;  Giovanetti, M.;  Yi, D.;  Weiss, D. J.;  Wint, G. R. W.;  Shearer, F. M.;  Funk, S.;  Nikolay, B.;  Fonseca, V.;  Adelino, T. E. R.;  Oliveira, M. A. A.;  Silva, M. V. F.;  Sacchetto, L.;  Figueiredo, P. O.;  Rezende, I. M.;  Mello, E. M.;  Said, R. F. C.;  Santos, D. A.;  Ferraz, M. L.;  Brito, M. G.;  Santana, L. F.;  Menezes, M. T.;  Brindeiro, R. M.;  Tanuri, A.;  dos Santos, F. C. P.;  Cunha, M. S.;  Nogueira, J. S.;  Rocco, I. M.;  da Costa, A. C.;  Komninakis, S. C. V.;  Azevedo, V.;  Chieppe, A. O.;  Araujo, E. S. M.;  Mendonca, M. C. L.;  dos Santos, C. C.;  dos Santos, C. D.;  Mares-Guia, A. M.;  Nogueira, R. M. R.;  Sequeira, P. C.;  Abreu, R. G.;  Garcia, M. H. O.;  Abreu, A. L.;  Okumoto, O.;  Kroon, E. G.;  de Albuquerque, C. F. C.;  Lewandowski, K.;  Pullan, S. T.;  Carroll, M.;  de Oliveira, T.;  Sabino, E. C.;  Souza, R. P.;  Suchard, M. A.;  Lemey, P.;  Trindade, G. S.;  Drumond, B. P.;  Filippis, A. M. B.;  Loman, N. J.;  Cauchemez, S.;  Alcantara, L. C. J.;  Pybus, O. G.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Estimating the climate significance of halogen-driven ozone loss in the tropical marine troposphere 期刊论文
Atmospheric Chemistry and Physics, 2012
作者:  A. Saiz-Lopez, J.-F. Lamarque, D. E. Kinnison, S. Tilmes, C. Ordóñez, J. J. Orlando, A. J. Conley, J. M. C. Plane, A. S. Mahajan, G. Sousa Santos, E. L. Atlas, D. R. Blake, S. P. Sander, S. Schauffler, A. M. Thompson, and G. Brasseur
收藏  |  浏览/下载:2/0  |  提交时间:2020/08/18