GSTDTAP

浏览/检索结果: 共20条,第1-10条 帮助

限定条件                
已选(0)清除 条数/页:   排序方式:
Fluxes, patterns and sources of phosphorus deposition in an urban-rural transition region in Southwest China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Yuanyuan Chen, Jiang Liu, Jiangyou Ran, Rong Huang, Xuesong Gao, Wei Zhou, Ting Lan, Dinghua Ou, Yan He, Yalan Xiong, Ling Luo, Lu Wang, and Ouping Deng
收藏  |  浏览/下载:43/0  |  提交时间:2022/07/08
Measurement report: The importance of biomass burning in light extinction and direct radiative effect of urban aerosol during the COVID-19 lockdown in Xi'an, China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Jie Tian, Qiyuan Wang, Huikun Liu, Yongyong Ma, Suixin Liu, Yong Zhang, Weikang Ran, Yongming Han, and Junji Cao
收藏  |  浏览/下载:13/0  |  提交时间:2022/07/08
Measurement report: Evaluation of sources and mixing state of black carbon aerosol under the background of emission reduction in the North China Plain: implications for radiative effect 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Qiyuan Wang, Li Li, Jiamao Zhou, Jianhuai Ye, Wenting Dai, Huikun Liu, Yong Zhang, Renjian Zhang, Jie Tian, Yang Chen, Yunfei Wu, Weikang Ran, and Junji Cao
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/21
Measurement report: Quantifying source contribution and radiative forcing of fossil fuel and biomass burning black carbon aerosol in the southeastern margin of Tibetan Plateau 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Huikun Liu, Qiyuan Wang, Li Xing, Yong Zhang, Ting Zhang, Weikang Ran, and Junji Cao
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/29
Molecular architecture of lineage allocation and tissue organization in early mouse embryo (vol 572, 528, 2019) 期刊论文
NATURE, 2020, 577 (7791) : E6-E6
作者:  Peng, Guangdun;  Suo, Shengbao;  Cui, Guizhong;  Yu, Fang;  Wang, Ran;  Chen, Jun;  Chen, Shirui;  Liu, Zhiwen;  Chen, Guoyu;  Qian, Yun;  Tam, Patrick P. L.;  Han, Jing-Dong J.;  Jing, Naihe
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03
Significant methane ebullition from alpine permafrost rivers on the East Qinghai-Tibet Plateau 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Zhang, Liwei;  Xia, Xinghui;  Liu, Shaoda;  Zhang, Sibo;  Li, Siling;  Wang, Junfeng;  Wang, Gongqin;  Gao, Hui;  Zhang, Zhenrui;  Wang, Qingrui;  Wen, Wu;  Liu, Ran;  Yang, Zhifeng;  Stanley, Emily H.;  Raymond, Peter A.
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
The wide-binary origin of (2014) MU69-like Kuiper belt contact binaries 期刊论文
NATURE, 2020, 580 (7804) : 463-+
作者:  Jiao, Lin;  Howard, Sean;  Ran, Sheng;  Wang, Zhenyu;  Rodriguez, Jorge Olivares;  Sigrist, Manfred;  Wang, Ziqiang;  Butch, Nicholas P.;  Madhavan, Vidya
收藏  |  浏览/下载:66/0  |  提交时间:2020/07/03

Following its flyby and first imaging of the Pluto-Charon binary, the New Horizons spacecraft visited the Kuiper belt object (KBO) 2014 MU69 (also known as (486958) Arrokoth). The imaging showed MU69 to be a contact binary that rotates at a low spin period (15.92 hours), is made of two individual lobes connected by a narrow neck and has a high obliquity (about 98 degrees)(1), properties that are similar to those of other KBO contact binaries inferred through photometric observations(2). However, all scenarios suggested so far for the origins of such configurations(3-5) have failed to reproduce these properties and their probable frequent occurrence in the Kuiper belt. Here we show that semi-secular perturbations(6,7) operating on only ultrawide KBO binaries close to their stability limit can robustly lead to gentle, slow binary mergers at arbitrarily high obliquities but low rotational velocities, reproducing the characteristics of MU69 and other similar oblique contact binaries. Using N-body simulations, we find that approximately 15 per cent of all ultrawide binaries with a cosine-uniform inclination distribution(5,9) are likely to merge through this process. Moreover, we find that such mergers are sufficiently gentle to deform the shape of the KBO only slightly. The semi-secular contact binary formation channel not only explains the observed properties of MU69, but may also apply to other Kuiper belt or asteroid belt binaries and in the Solar System and extra-solar moon systems.


The high obliquity and low rotation period of the Kuiper belt object (2014) MU69 and other similar contact binaries is successfully reproduced from the collision and post-collision characteristics of initially wide binaries.


  
A self-activating orphan receptor 期刊论文
NATURE, 2020, 579 (7797) : 35-35
作者:  Wang, Lin;  Wu, Juehui;  Li, Jun;  Yang, Hua;  Tang, Tianqi;  Liang, Haijiao;  Zuo, Mianyong;  Wang, Jie;  Liu, Haipeng;  Liu, Feng;  Chen, Jianxia;  Liu, Zhonghua;  Wang, Yang;  Peng, Cheng;  Wu, Xiangyang;  Zheng, Ruijuan;  Huang, Xiaochen;  Ran, Yajun;  Rao, Zihe;  Ge, Baoxue
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics.


  
Natural sea-salt emissions moderate the climate forcing of anthropogenic nitrate 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 771-786
作者:  Chen, Ying;  Cheng, Yafang;  Ma, Nan;  Wei, Chao;  Ran, Liang;  Wolke, Ralf;  Groess, Johannes;  Wang, Qiaoqiao;  Pozzer, Andrea;  van der Gon, Hugo A. C. Denier;  Spindler, Gerald;  Lelieveld, Jos;  Tegen, Ina;  Su, Hang;  Wiedensohler, Alfred
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02