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Convective isolation of Hadean mantle reservoirs through Archean time 期刊论文
Proceedings of the National Academy of Science, 2021
作者:  Jonas Tusch;  Carsten Münker;  Eric Hasenstab;  Mike Jansen;  Chris S. Marien;  Florian Kurzweil;  Martin J. Van Kranendonk;  Hugh Smithies;  Wolfgang Maier;  Dieter Garbe-Schönberg
收藏  |  浏览/下载:6/0  |  提交时间:2020/12/28
The Aarhus Chamber Campaign on Highly Oxygenated Organic Molecules and Aerosols (ACCHA): particle formation, organic acids, and dimer esters from α-pinene ozonolysis at different temperatures 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Kasper Kristensen, Louise N. Jensen, Lauriane L. J. Quéléver, Sigurd Christiansen, Bernadette Rosati, Jonas Elm, Ricky Teiwes, Henrik B. Pedersen, Marianne Glasius, Mikael Ehn, and Merete Bilde
收藏  |  浏览/下载:7/0  |  提交时间:2020/11/09
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Simultaneous in situ measurements of small-scale structures in neutral, plasma, and atomic oxygen densities during the WADIS sounding rocket project 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (17) : 11443-11460
作者:  Strelnikov, Boris;  Eberhart, Martin;  Friedrich, Martin;  Hedin, Jonas;  Khaplanov, Mikhail;  Baumgarten, Gerd;  Williams, Bifford P.;  Staszak, Tristan;  Asmus, Heiner;  Strelnikova, Irina;  Latteck, Ralph;  Grygalashvyly, Mykhaylo;  Luebken, Franz-Josef;  Hoeffner, Josef;  Woerl, Raimund;  Gumbel, Joerg;  Loehle, Stefan;  Fasoulas, Stefanos;  Rapp, Markus;  Barjatya, Aroh;  Taylor, Michael J.;  Pautet, Pierre-Dominique
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
The formation of human populations in South and Central Asia 期刊论文
SCIENCE, 2019, 365 (6457) : 999-+
作者:  Narasimhan, Vagheesh M.;  Patterson, Nick;  Moorjani, Priya;  Rohland, Nadin;  Bernardos, Rebecca;  Mallick, Swapan;  Lazaridis, Losif;  Nakatsuka, Nathan;  Olalde, Iffigo;  Lipson, Mark;  Kim, Alexander M.;  Olivieri, Luca M.;  Coppa, Alfredo;  Vidale, Massimo;  Mallory, James;  Moiseyev, Vyacheslav;  Kitov, Egor;  Monge, Janet;  Adamski, Nicole;  Alexi, Neel;  Broomandkhoshbacht, Nasreen;  Candilio, Francesca;  Callan, Kimberly;  Cheronet, Olivia;  Culleton, Brendan J.;  Ferry, Matthew;  Fernandes, Daniel;  Freilih, Suzanne;  Gamarra, Beatriz;  Gaudio, Daniel;  Hajdinjak, Mateja;  Harney, Eadaoin;  Harper, Thomas K.;  Keatin, Denise;  Lawson, Ann Marie;  Mah, Matthew;  Mandl, Kirsten;  Michel, Megan;  Novak, Mario;  Oppenheimer, Jonas;  Rai, Niraj;  Sirak, Kendra;  Slon, Viviane;  Stewardson, Kristin;  Zalzala, Fatma;  Zhang, Zhao;  Akhatov, Gaziz;  Bagashev, Anatoly N.;  Bagnera, Alessandra;  Baitanayev, Bauryzhan;  Bendezu-Sarmiento, Julio;  Bissembaev, Arman A.;  Bonora, Gian Luca;  Chargynov, Temirlan T.;  Chikisheva, Tatiana;  Dashkovskiy, Petr K.;  Derevianko, Anatoly;  Dobes, Miroslav;  Douka, Katerina;  Dubova, Nadezhda;  Duisengali, Meiram N.;  Enshin, Dmitry;  Epimakhov, Andrey;  Fribus, Alexey V.;  Fuller, Dorian;  Goryachev, Alexander;  Gromov, Andrey;  Grushin, Sergey P.;  Hanks, Bryan;  Judd, Margaret;  Kazizov, Erlan;  Khokhlov, Aleksander;  Krygin, Aleksander P.;  Kupriyanova, Elena;  Kuznetsov, Pavel;  Luiseli, Donata;  Maksudov, Farhod;  Mamedov, Asian M.;  Mamirov, Talgat B.;  Meiklejohn, Christopher;  Merrett, Deborah C.;  Micheli, Roberto;  Mochalov, Oleg;  Mustafokulov, Samariddin;  Nayak, Ayushi;  Pettener, Davide;  Potts, Richard;  Razhev, Dmitry;  Rykun, Marina;  Sarno, Stefania;  Savenkova, Tatyana M.;  Sikhymbaeva, Kulyan;  Slepchenko, Sergey M.;  Soltobaev, Oroz A.;  Stepanova, Nadezhda;  Svyatko, Svetlana;  Tabaldiev, Kubatbek;  Teschler-Nicola, Maria;  Tishkin, Alexey A.;  Tkachev, Vitaly V.;  Vasilyev, Sergey;  Veleminsky, Petr;  Voyakin, Dmitriy;  Yermolayeva, Antonina;  Zahir, Muhammad;  Zubkov, Valery S.;  Zubova, Alisa;  Shinde, Vasant S.;  Lalueza-Fox, Carles;  Meyer, Matthias;  Anthony, David;  Boivin, Nicole;  Thangaraj, Kumnarasamy;  Kennett, Douglas J.;  Frachetti, Michael;  Pinhasi, Ron;  Reich, David
收藏  |  浏览/下载:23/0  |  提交时间:2019/11/27
Ancient DNA reveals a multistep spread of the first herders into sub-Saharan Africa 期刊论文
SCIENCE, 2019, 365 (6448) : 44-+
作者:  Prendergast, Mary E.;  Lipson, Mark;  Sawchuk, Elizabeth A.;  Olalde, Inigo;  Ogola, Christine A.;  Rohland, Nadin;  Sirak, Kendra A.;  Adamski, Nicole;  Bernardos, Rebecca;  Broomandkhoshbacht, Nasreen;  Callan, Kimberly;  Culleton, Brendan J.;  Eccles, Laurie;  Harper, Thomas K.;  Lawson, Ann Marie;  Mah, Matthew;  Oppenheimer, Jonas;  Stewardson, Kristin;  Zalzala, Fatma;  Ambrose, Stanley H.;  Ayodo, George;  Gates, Henry Louis, Jr.;  Gidna, Agness O.;  Katongo, Maggie;  Kwekason, Amandus;  Mabulla, Audax Z. P.;  Mudenda, George S.;  Ndiema, Emmanuel K.;  Nelson, Charles;  Robertshaw, Peter;  Kennett, Douglas J.;  Manthi, Fredrick K.;  Reich, David
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
The genomic history of the Iberian Peninsula over the past 8000 years 期刊论文
SCIENCE, 2019, 363 (6432) : 1230-+
作者:  Olalde, Inigo;  Mallick, Swapan;  Patterson, Nick;  Rohland, Nadin;  Villalba-Mouco, Vanessa;  Silva, Marina;  Dulias, Katharina;  Edwards, Ceiridwen J.;  Gandini, Francesca;  Pala, Maria;  Soares, Pedro;  Ferrando-Bernal, Manuel;  Adamski, Nicole;  Broomandkhoshbacht, Nasreen;  Cheronet, Olivia;  Culleton, Brendan J.;  Fernandes, Daniel;  Lawson, Ann Marie;  Mah, Matthew;  Oppenheimer, Jonas;  Stewardson, Kristin;  Zhang, Zhao;  Arenas, Juan Manuel Jimenez;  Moyano, Isidro Jorge Toro;  Salazar-Garcia, Domingo C.;  Castanyer, Pere;  Santos, Marta;  Tremoleda, Joaquim;  Lozano, Marina;  Borja, Pablo Garcia;  Fernandez-Eraso, Javier;  Mujika-Alustiza, Jose Antonio;  Barroso, Cecilio;  Bermudez, Francisco J.;  Minguez, Enrique Viguera;  Burch, Josep;  Coromina, Neus;  Vivo, David;  Cebria, Artur;  Fullola, Josep Maria;  Garcia-Puchol, Oreto;  Morales, Juan Ignacio;  Oms, F. Xavier;  Majo, Tona;  Verges, Josep Maria;  Diaz-Carvajal, Antonia;  Ollich-Castanyer, Imma;  Lopez-Cachero, F. Javier;  Silva, Ana Maria;  Alonso-Fernandez, Carmen;  De Castro, German Delibes;  Echevarria, Javier Jimenez;  Moreno-Marquez, Adolfo;  Berlanga, Guillermo Pascual;  Ramos-Garcia, Pablo;  Munoz, Jose Ramos;  Vila, Eduardo Vijande;  Arzo, Gustau Aguilella;  Arroyo, Angel Esparza;  Lillios, Katina T.;  Mack, Jennifer;  Velasco-Vazquez, Javier;  Waterman, Anna;  Enrich, Luis Benitez De Lugo;  Sanchez, Maria Benito;  Agusti, Bibiana;  Codina, Ferran;  De Prado, Gabriel;  Estalrrich, Almudena;  Flores, Alvaro Fernandez;  Finlayson, Clive;  Finlayson, Geraldine;  Finlayson, Stewart;  Giles-Guzman, Francisco;  Rosas, Antonio;  Gonzalez, Virginia Barciela;  Atienzar, Gabriel Garcia;  Perez, Mauro S. Hernandez;  Llanos, Armando;  Marco, Yolanda Carrion;  Beneyto, Isabel Collado;  Lopez-Serrano, David;  Tormo, Mario Sanz;  Valera, Antonio C.;  Blasco, Concepcion;  Liesau, Corina;  Rios, Patricia;  Daura, Joan;  de Pedro Micho, Maria Jesus;  Diez-Castillo, Agustin A.;  Fernandez, Raul Flores;  Farre, Joan Frances;  Garrido-Pena, Rafael;  Goncalves, Victor S.;  Guerra-Doce, Elisa;  Herrero-Corral, Ana Mercedes;  Juan-Cabanilles, Joaquim;  Lopez-Reyes, Daniel;  McClure, Sarah B.;  Perez, Marta Merino;  Foix, Arturo Oliver;  Borras, Montserrat Sanz;  Sousa, Ana Catarina;  Encinas, Julio Manuel Vidal;  Kennett, Douglas J.;  Richards, Martin B.;  Alt, Kurt Werner;  Haak, Wolfgang;  Pinhasi, Ron;  Lalueza-Fox, Carles;  Reich, David
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Deciphering the diagenetic history of the El Abra Formation of eastern Mexico using reordered clumped isotope temperatures and U-Pb dating 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2018, 130: 617-629
作者:  Lawson, Michael;  Shenton, Brock J.;  Stolper, Daniel A.;  Eiler, John M.;  Rasbury, E. Troy;  Becker, Thomas P.;  Phillips-Lander, Charity M.;  Buono, Antonio S.;  Becker, Stephen P.;  Pottorf, Robert;  Gray, Gary G.;  Yurewicz, Don;  Gournay, Jonas
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Petroleum dynamics in the sea and influence of subsea dispersant injection during Deepwater Horizon 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (38) : 10065-10070
作者:  Gros, Jonas;  Socolofsky, Scott A.;  Dissanayake, Anusha L.;  Jun, Inok;  Zhao, Lin;  Boufadel, Michel C.;  Reddy, Christopher M.;  Arey, J. Samuel
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Deepwater Horizon  oil spill  petroleum  offshore drilling  dispersant  
Protecting unauthorized immigrant mothers improves their children's mental health 期刊论文
SCIENCE, 2017, 357 (6355) : 1041-1044
作者:  Hainmueller, Jens;  Lawrence, Duncan;  Marten, Linna;  Black, Bernard;  Figueroa, Lucila;  Hotard, Michael;  Jimenez, Tomas R.;  Mendoza, Fernando;  Rodriguez, Maria I.;  Swartz, Jonas J.;  Laitin, David D.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27