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DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging 期刊论文
SCIENCE, 2019, 365 (6454) : 699-+
作者:  Abdelfattah, Ahmed S.;  Kawashima, Takashi;  Singh, Amrita;  Novak, Ondrej;  Liu, Hui;  Shuai, Yichun;  Huang, Yi-Chieh;  Campagnola, Luke;  Seeman, Stephanie C.;  Yu, Jianing;  Zheng, Jihong;  Grimm, Jonathan B.;  Patel, Ronak;  Friedrich, Johannes;  Mensh, Brett D.;  Paninski, Liam;  Macklin, John J.;  Murphy, Gabe J.;  Podgorski, Kaspar;  Lin, Bei-Jung;  Chen, Tsai-Wen;  Turner, Glenn C.;  Liu, Zhe;  Koyama, Minoru;  Svoboda, Karel;  Ahrens, Misha B.;  Lavis, Luke D.;  Schreiter, Eric R.
收藏  |  浏览/下载：20/0  |  提交时间：2019/11/27
Amyloid beta oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes 期刊论文
SCIENCE, 2019, 365 (6450) : 250-+
作者:  Nortley, Ross;  Korte, Nils;  Izquierdo, Pablo;  Hirunpattarasilp, Chanawee;  Mishra, Anusha;  Jaunmuktane, Zane;  Kyrargyri, Vasiliki;  Pfeiffer, Thomas;  Khennouf, Lila;  Madry, Christian;  Gong, Hui;  Richard-Loendt, Angela;  Huang, Wenhui;  Saito, Takashi;  Saido, Takaomi C.;  Brandner, Sebastian;  Sethi, Huma;  Attwell, David
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Direct arene C-H fluorination with F-18(-) via organic photoredox catalysis 期刊论文
SCIENCE, 2019, 364 (6446) : 1170-+
作者:  Chen, Wei;  Huang, Zeng;  Tay, Nicholas E. S.;  Giglio, Benjamin;  Wang, Mengzhe;  Wang, Hui;  Wu, Zhanhong;  Nicewicz, David A.;  Li, Zibo
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Double-negative-index ceramic aerogels for thermal superinsulation 期刊论文
SCIENCE, 2019, 363 (6428) : 723-+
作者:  Xu, Xiang;  Zhang, Qiangqiang;  Hao, Menglong;  Hu, Yuan;  Lin, Zhaoyang;  Peng, Lele;  Wang, Tao;  Ren, Xuexin;  Wang, Chen;  Zhao, Zipeng;  Wan, Chengzhang;  Fei, Huilong;  Wang, Lei;  Zhu, Jian;  Sun, Hongtao;  Chen, Wenli;  Du, Tao;  Deng, Biwei;  Cheng, Gary J.;  Shakir, Imran;  Dames, Chris;  Fisher, Timothy S.;  Zhang, Xiang;  Li, Hui;  Huang, Yu;  Duan, Xiangfeng
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Drought losses in China might double between the 1.5 degrees C and 2.0 degrees C warming 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (42) : 10600-10605
作者:  Su, Buda;  Huang, Jinlong;  Fischer, Thomas;  Wang, Yanjun;  Kundzewicz, Zbigniew W.;  Zhai, Jianqing;  Sun, Hemin;  Wang, Anqian;  Zeng, Xiaofan;  Wang, Guojie;  Tao, Hui;  Gemmer, Marco;  Li, Xiucang;  Jiang, Tong
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
drought  drought losses  projections  global warming  China  
Allelic reprogramming of 3D chromatin architecture during early mammalian development 期刊论文
NATURE, 2017, 547 (7662) : 232-+
作者:  Du, Zhenhai;  Zheng, Hui;  Huang, Bo;  Ma, Rui;  Wu, Jingyi;  Zhang, Xianglin;  He, Jing;  Xiang, Yunlong;  Wang, Qiujun;  Li, Yuanyuan;  Ma, Jing;  Zhang, Xu;  Zhang, Ke;  Wang, Yang;  Zhang, Michael Q.;  Gao, Juntao;  Dixon, Jesse R.;  Wang, Xiaowo;  Zeng, Jianyang;  Xie, Wei
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition 期刊论文
SCIENCE, 2017, 355 (6332) : 1428-+
作者:  Hui, Enfu;  Cheung, Jeanne;  Zhu, Jing;  Su, Xiaolei;  Taylor, Marcus J.;  Wallweber, Heidi A.;  Sasmal, Dibyendu K.;  Huang, Jun;  Kim, Jeong M.;  Mellman, Ira;  Vale, Ronald D.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27