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Response to Comment on “Forest microclimate dynamics drive plant responses to warming” 期刊论文
Science, 2020
作者:  Florian Zellweger;  Pieter De Frenne;  Jonathan Lenoir;  Pieter Vangansbeke;  Kris Verheyen;  Markus Bernhardt-Römermann;  Lander Baeten;  Radim Hédl;  Imre Berki;  Jörg Brunet;  Hans Van Calster;  Markéta Chudomelová;  Guillaume Decocq;  Thomas Dirnböck;  Tomasz Durak;  Thilo Heinken;  Bogdan Jaroszewicz;  Martin Kopecký;  František Máliš;  Martin Macek;  Marek Malicki;  Tobias Naaf;  Thomas A. Nagel;  Adrienne Ortmann-Ajkai;  Petr Petřík;  Remigiusz Pielech;  Kamila Reczyńska;  Wolfgang Schmidt;  Tibor Standovár;  Krzysztof Świerkosz;  Balázs Teleki;  Ondřej Vild;  Monika Wulf;  David Coomes
收藏  |  浏览/下载:13/0  |  提交时间:2020/11/30
Climate change facilitates a parasite’s host exploitation via temperature‐mediated immunometabolic processes 期刊论文
Global Change Biology, 2020
作者:  ;  rn P. Scharsack;  Bartholomä;  us Wieczorek;  Alexander Schmidt‐;  Drewello;  Janine Bü;  scher;  Frederik Franke;  Andrew Moore;  Antoine Branca;  Anika Witten;  Monika Stoll;  Erich Bornberg‐;  Bauer;  Susann Wicke;  Joachim Kurtz
收藏  |  浏览/下载:12/0  |  提交时间:2020/11/20
Cartilage-inspired, lipid-based boundary-lubricated hydrogels 期刊论文
Science, 2020
作者:  Weifeng Lin;  Monika Kluzek;  Noa Iuster;  Eyal Shimoni;  Nir Kampf;  Ronit Goldberg;  Jacob Klein
收藏  |  浏览/下载:5/0  |  提交时间:2020/10/20
COSORE: A community database for continuous soil respiration and other soil‐atmosphere greenhouse gas flux data 期刊论文
Global Change Biology, 2020
作者:  Ben Bond‐;  Lamberty;  Danielle S. Christianson;  Avni Malhotra;  Stephanie C. Pennington;  Debjani Sihi;  Amir AghaKouchak;  Hassan Anjileli;  M. Altaf Arain;  Juan J. Armesto;  Samaneh Ashraf;  Mioko Ataka;  Dennis Baldocchi;  Thomas Andrew Black;  Nina Buchmann;  Mariah S. Carbone;  Shih‐;  Chieh Chang;  Patrick Crill;  Peter S. Curtis;  Eric A. Davidson;  Ankur R. Desai;  John E. Drake;  Tarek S. El‐;  Madany;  Michael Gavazzi;  Carolyn‐;  Monika Gö;  rres;  Christopher M. Gough;  Michael Goulden;  Jillian Gregg;  Omar Gutié;  rrez del Arroyo;  Jin‐;  Sheng He;  Takashi Hirano;  Anya Hopple;  Holly Hughes;  ;  rvi Jä;  rveoja;  Rachhpal Jassal;  Jinshi Jian;  Haiming Kan;  Jason Kaye;  Yuji Kominami;  Naishen Liang;  David Lipson;  Catriona A. Macdonald;  Kadmiel Maseyk;  Kayla Mathes;  Marguerite Mauritz;  Melanie A. Mayes;  Steve McNulty;  Guofang Miao;  Mirco Migliavacca;  Scott Miller;  Chelcy F. Miniat;  Jennifer G. Nietz;  Mats B. Nilsson;  Asko Noormets;  Hamidreza Norouzi;  Christine S. O’;  Connell;  Bruce Osborne;  Cecilio Oyonarte;  Zhuo Pang;  Matthias Peichl;  Elise Pendall;  Jorge F. Perez‐;  Quezada;  Claire L. Phillips;  Richard P. Phillips;  James W. Raich;  Alexandre A. Renchon;  Nadine K. Ruehr;  Enrique P. Sá;  nchez‐;  Cañ;  ete;  Matthew Saunders;  Kathleen E. Savage;  Marion Schrumpf;  Russell L. Scott;  Ulli Seibt;  Whendee L. Silver;  Wu Sun;  Daphne Szutu;  Kentaro Takagi;  Masahiro Takagi;  Munemasa Teramoto;  Mark G. Tjoelker;  Susan Trumbore;  Masahito Ueyama;  Rodrigo Vargas;  Ruth K. Varner;  Joseph Verfaillie;  Christoph Vogel;  Jinsong Wang;  Greg Winston;  Tana E. Wood;  Juying Wu;  Thomas Wutzler;  Jiye Zeng;  Tianshan Zha;  Quan Zhang;  Junliang Zou
收藏  |  浏览/下载:14/0  |  提交时间:2020/10/12
Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:40/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Remote sensing reveals Antarctic green snow algae as important terrestrial carbon sink 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Gray, Andrew;  Krolikowski, Monika;  Fretwell, Peter;  Convey, Peter;  Peck, Lloyd S.;  Mendelova, Monika;  Smith, Alison G.;  Davey, Matthew P.
收藏  |  浏览/下载:13/0  |  提交时间:2020/05/25
Forest microclimate dynamics drive plant responses to warming 期刊论文
Science, 2020
作者:  Florian Zellweger;  Pieter De Frenne;  Jonathan Lenoir;  Pieter Vangansbeke;  Kris Verheyen;  Markus Bernhardt-Römermann;  Lander Baeten;  Radim Hédl;  Imre Berki;  Jörg Brunet;  Hans Van Calster;  Markéta Chudomelová;  Guillaume Decocq;  Thomas Dirnböck;  Tomasz Durak;  Thilo Heinken;  Bogdan Jaroszewicz;  Martin Kopecký;  František Máliš;  Martin Macek;  Marek Malicki;  Tobias Naaf;  Thomas A. Nagel;  Adrienne Ortmann-Ajkai;  Petr Petřík;  Remigiusz Pielech;  Kamila Reczyńska;  Wolfgang Schmidt;  Tibor Standovár;  Krzysztof Świerkosz;  Balázs Teleki;  Ondřej Vild;  Monika Wulf;  David Coomes
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/20
Late-stage oxidative C(sp(3))-H methylation 期刊论文
NATURE, 2020, 580 (7805) : 621-+
作者:  Fessler, Evelyn;  Eckl, Eva-Maria;  Schmitt, Sabine;  Mancilla, Igor Alves;  Meyer-Bender, Matthias F.;  Hanf, Monika;  Philippou-Massier, Julia;  Krebs, Stefan;  Zischka, Hans;  Jae, Lucas T.
收藏  |  浏览/下载:46/0  |  提交时间:2020/07/03

Frequently referred to as the '  magic methyl effect'  , the installation of methyl groups-especially adjacent (alpha) to heteroatoms-has been shown to dramatically increase the potency of biologically active molecules(1-3). However, existing methylation methods show limited scope and have not been demonstrated in complex settings(1). Here we report a regioselective and chemoselective oxidative C(sp(3))-H methylation method that is compatible with late-stage functionalization of drug scaffolds and natural products. This combines a highly site-selective and chemoselective C-H hydroxylation with a mild, functional-group-tolerant methylation. Using a small-molecule manganese catalyst, Mn(CF3PDP), at low loading (at a substrate/catalyst ratio of 200) affords targeted C-H hydroxylation on heterocyclic cores, while preserving electron-neutral and electron-rich aryls. Fluorine- or Lewis-acid-assisted formation of reactive iminium or oxonium intermediates enables the use of a mildly nucleophilic organoaluminium methylating reagent that preserves other electrophilic functionalities on the substrate. We show this late-stage C(sp(3))-H methylation on 41 substrates housing 16 different medicinally important cores that include electron-rich aryls, heterocycles, carbonyls and amines. Eighteen pharmacologically relevant molecules with competing sites-including drugs (for example, tedizolid) and natural products-are methylated site-selectively at the most electron rich, least sterically hindered position. We demonstrate the syntheses of two magic methyl substrates-an inverse agonist for the nuclear receptor RORc and an antagonist of the sphingosine-1-phosphate receptor-1-via late-stage methylation from the drug or its advanced precursor. We also show a remote methylation of the B-ring carbocycle of an abiraterone analogue. The ability to methylate such complex molecules at late stages will reduce synthetic effort and thereby expedite broader exploration of the magic methyl effect in pursuit of new small-molecule therapeutics and chemical probes.


A manganese-catalysed oxidative C(sp(3))-H methylation method allows a methyl group to be selectively installed into medicinally important heterocycles, providing a way to improve pharmaceuticals and better understand the '  magic methyl effect'  .


  
The ABC exporter IrtAB imports and reduces mycobacterial siderophores 期刊论文
NATURE, 2020, 580 (7803) : 413-+
作者:  Fessler, Evelyn;  Eckl, Eva-Maria;  Schmitt, Sabine;  Mancilla, Igor Alves;  Meyer-Bender, Matthias F.;  Hanf, Monika;  Philippou-Massier, Julia;  Krebs, Stefan;  Zischka, Hans;  Jae, Lucas T.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Intracellular replication of the deadly pathogen Mycobacterium tuberculosis relies on the production of small organic molecules called siderophores that scavenge iron from host proteins(1). M. tuberculosis produces two classes of siderophore, lipid-bound mycobactin and water-soluble carboxymycobactin(2,3). Functional studies have revealed that iron-loaded carboxymycobactin is imported into the cytoplasm by the ATP binding cassette (ABC) transporter IrtAB(4), which features an additional cytoplasmic siderophore interaction domain(5). However, the predicted ABC exporter fold of IrtAB is seemingly contradictory to its import function. Here we show that membrane-reconstituted IrtAB is sufficient to import mycobactins, which are then reduced by the siderophore interaction domain to facilitate iron release. Structure determination by X-ray crystallography and cryo-electron microscopy not only confirms that IrtAB has an ABC exporter fold, but also reveals structural peculiarities at the transmembrane region of IrtAB that result in a partially collapsed inward-facing substrate-binding cavity. The siderophore interaction domain is positioned in close proximity to the inner membrane leaflet, enabling the reduction of membrane-inserted mycobactin. Enzymatic ATPase activity and in vivo growth assays show that IrtAB has a preference for mycobactin over carboxymycobactin as its substrate. Our study provides insights into an unusual ABC exporter that evolved as highly specialized siderophore-import machinery in mycobacteria.