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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Collaboration across boundaries in the Amazon 期刊论文
SCIENCE, 2019, 366 (6466) : 699-700
作者:  Prist, Paula Ribeiro;  Levin, Noam;  Metzger, Jean Paul;  de Mello, Kaline;  Costa, Micheli Duarte de Paula;  Castagnino, Romi;  Cortes-Ramirez, Javier;  Lin, Da-Li;  Butt, Nathalie;  Lloyd, Thomas J.;  Lopez-Cubillos, Sofia;  Mayfield, Helen J.;  Negret, Pablo Jose;  Oliveira-Bevan, Isabella;  Reside, April E.;  Rhodes, Jonathan R.;  Simmons, B. Alexander;  Suarez-Castro, A. Felipe;  Kark, Salit
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum 期刊论文
SCIENCE, 2019, 366 (6464) : 454-+
作者:  Haldipur, Parthiv;  Aldinger, Kimberly A.;  Bernardo, Silvia;  Deng, Mei;  Timms, Andrew E.;  Overman, Lynne M.;  Winter, Conrad;  Lisgo, Steven N.;  Razavi, Ferechte;  Silvestri, Evelina;  Manganaro, Lucia;  Adle-Biasette, Homa;  Guilmiot, Fabien;  Russo, Rosa;  Kidron, Debora;  Hof, Patrick R.;  Gerrelli, Dianne;  Lindsay, Susan J.;  Dobyns, William B.;  Glass, Ian A.;  Alexandre, Paula;  Millen, Kathleen J.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Maschalidi, Sophia;  Nunes-Hasler, Paula;  Nascimento, Clarissa R.;  Sallent, Ignacio;  Lannoy, Valerie;  Garfa-Traore, Meriem;  Cagnard, Nicolas;  Sepulveda, Fernando E.;  Vargas, Pablo;  Lennon-Dumenil, Ana-Maria;  van Endert, Peter;  Capiod, Thierry;  Demaurex, Nicolas;  Darrasse-Jeze, Guillaume;  Manoury, Benedicte
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes 期刊论文
NATURE, 2019, 571 (7763) : 72-+
作者:  Johnson, Eachan O.;  LaVerriere, Emily;  Office, Emma;  Stanley, Mary;  Meyer, Elisabeth;  Kawate, Tomohiko;  Gomez, James E.;  Audette, Rebecca E.;  Bandyopadhyay, Nirmalya;  Betancourt, Natalia;  Delano, Kayla;  Da Silva, Israel;  Davis, Joshua;  Gallo, Christina;  Gardner, Michelle;  Golas, Aaron J.;  Guinn, Kristine M.;  Kennedy, Sofia;  Korn, Rebecca;  McConnell, Jennifer A.;  Moss, Caitlin E.;  Murphy, Kenan C.;  Nietupski, Raymond M.;  Papavinasasundaram, Kadamba G.;  Pinkham, Jessica T.;  Pino, Paula A.;  Proulx, Megan K.;  Ruecker, Nadine;  Song, Naomi;  Thompson, Matthew;  Trujillo, Carolina;  Wakabayashi, Shoko;  Wallach, Joshua B.;  Watson, Christopher;  Ioerger, Thomas R.;  Lander, Eric S.;  Hubbard, Brian K.;  Serrano-Wu, Michael H.;  Ehrt, Sabine;  Fitzgerald, Michael;  Rubin, Eric J.;  Sassetti, Christopher M.;  Schnappinger, Dirk;  Hung, Deborah T.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Biological control of Gonipterus: Uncovering the associations between eucalypts, weevils and parasitoids in their native range 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 443: 106-116
作者:  Garcia, Andre;  Allen, Geoff R.;  Oberprieler, Rolf G.;  Ramos, Ana Paula;  Valente, Carlos;  Reis, Ana;  Franco, Jose Carlos;  Branco, Manuela
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Eucalyptus  Anaphes inexpectatus  A. nitens  A. tasmaniae  Gonipterus platensis  Host associations  
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Shungin, Dmitry;  Hawort, Simon;  Divaris, Kimon;  Agler, Cary S.;  Kamatani, Yoichiro;  Lee, Myoung Keun;  Grinde, Kelsey;  Hindy, George;  Alaraudanjoki, Viivi;  Pesonen, Paula;  Teumer, Alexander;  Holtfreter, Birte;  Sakaue, Saori;  Hirata, Jun;  Yu, Yau-Hua;  Ridker, Paul M.;  Giulianini, Franco;  Chasman, Daniel, I;  Magnusson, Patrik K. E.;  Sudo, Takeaki;  Okada, Yukinori;  Voelker, Uwe;  Kocher, Thomas;  Anttonen, Vuokko;  Laitala, Marja-Liisa;  Orho-Melander, Marju;  Sofer, Tamar;  Shaffer, John R.;  Vieira, Alexandre;  Marazita, Mary L.;  Kubo, Michiaki;  Furuichi, Yasushi;  North, Kari E.;  Offenbacher, Steve;  Ingelsson, Erik;  FrankS, Paul W.;  Timpson, Nicholas J.;  Johansson, Ingegerd
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
A planetesimal orbiting within the debris disc around a white dwarf star 期刊论文
SCIENCE, 2019, 364 (6435) : 66-+
作者:  Manser, Christopher J.;  Gansicke, Boris T.;  Eggl, Siegfried;  Hollands, Mark;  Izquierdo, Paula;  Koester, Detlev;  Landstreet, John D.;  Lyra, Wladimir;  Marsh, Thomas R.;  Meru, Farzana;  Mustill, Alexander J.;  Rodriguez-Gil, Pablo;  Toloza, Odette;  Veras, Dimitri;  Wilson, David J.;  Burleigh, Matthew R.;  Davies, Melvyn B.;  Farihi, Jay;  Fusillo, Nicola Gentile;  de Martino, Domitilla;  Parsons, Steven G.;  Quirrenbach, Andreas;  Raddi, Roberto;  Reffert, Sabine;  Del Santo, Melania;  Schreiber, Matthias R.;  Silvotti, Roberto;  Toonen, Silvia;  Villaver, Eva;  Wyatt, Mark;  Xu, Siyi;  Zwart, Simon Portegies
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Nitrogen cycling in monospecific and mixed-species plantations of Acacia mangium and Eucalyptus at 4 sites in Brazil 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 436: 56-67
作者:  Voigtlaender, M.;  Brandani, C. B.;  Caldeira, D. R. M.;  Tardy, F.;  Bouillet, J. -P.;  Goncalves, J. L. M.;  Moreira, M. Z.;  Leite, F. P.;  Brunet, D.;  Paula, R. R.;  Laclau, J. -P.
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Organic matter  N-2 fixation  Eucalypt  Litterfall  Nutrition  Tree mixtures  Tropical plantations  
Empowering Latina scientists 期刊论文
SCIENCE, 2019, 363 (6429) : 825-826
作者:  Bernal, Ximena E.;  Rojas, Bibiana;  Pinto-E, Maria Alejandra;  Mendoza-Henao, Angela M.;  Herrera-Montes, Adriana;  Isabel Herrera-Montes, Maria;  Caceres Franco, Andrea del Pilar;  Ceron-Souza, Ivania;  Paz, Andrea;  Vergara, Daniela;  Barragan Contreras, Leidy Alejandra;  Salazar, Camilo;  Bohorquez Alonso, Martha Lucia;  Guarnizo, Carlos E.;  Sanchez, Adriana;  Olaya-Castro, Alexandra;  Urbina-Cardona, Nicolas;  Guayasamin, Juan M.;  Uy, Floria Mora-Kepfer;  Feris, Faride Lamadrid;  Franco-Orozco, Barbara;  Munoz, Martha M.;  Patricia Rincon-Diaz, Martha;  Sanchez Herrera, Melissa;  Betancourth-Cundar, Mileidy;  Tarvin, Rebecca D.;  Marquez, Roberto;  Lopez-Aguirre, Camilo;  Ron, Santiago R.;  Ramirez, Santiago;  Paez-Vacas, Monica;  Gaitan-Espitia, Juan Diego;  Navarrete-Mendez, Maria J.;  Vianna, Juliana A.;  Varela-Jaramillo, Andrea;  Sanchez-Martinez, Paola M.;  Caminer Rodriguez, Marcel Adrian;  Garcia-Robledo, Carlos;  Kuprewicz, Erin K.;  Gomez-Bahamon, Valentina;  Chacon-Vargas, Katherine;  Trillo, Alex;  Ramirez Castaneda, Valeria;  Buenaventura, Eliana;  Carolina Monmany-Garzia, A.;  Carolina Carnaval, Ana;  Dick, Christopher W.;  Jose Andrade-Nunez, Maria;  Carvajal Castro, Juan David;  Marcela Pinto, Diana;  Camargo-Sanabria, Angela A.;  Lips, Karen R.;  Motta-Gonzalez, Diana;  Canedo, Clarissa;  Melissa Diaz, Jhandra;  Navarro-Suarez, Adriana M.;  Corredor, Karen;  Roa-Varon, Adela;  Flechas, Sandra V.;  Andres Martinez-Lanfranco, Juan;  Chiarioni Thome, Maria Tereza;  Caldwell, Michael S.;  Ballestas, Onil;  Mejia M, Carolina;  Chaverri, Gloriana;  Rossi, Alejandra;  Bonaccorso, Elisa;  Pimiento, Catalina;  Guerrero, Rafael F.;  Warkentin, Karen M.;  Montoya-Pachongo, Carolina;  Alvarez, Silvia J.;  Gonzalez-Duran, Gustavo;  Anganoy-Criollo, Marvin;  Martinez-Habibe, Maria Cristina;  Ramirez, Juan P.;  Burrowes, Patricia;  Catenazzi, Alessandro;  Riveros, Andre J.;  Targino, Mariane;  Velez, Alejandro;  Vargas, Oscar M.;  Zapata, Felipe;  Waltrick, Camilla Spengler;  Ceron, Karoline;  Segovia Salcedo, Claudia;  Silva-Velasco, Martha;  Ochoa-Herrera, Valeria;  Medina, Iliana;  Narins, Peter M.;  Alves Saccol, Suelen da Silva;  de Castro Godinho, Marcela Brasil;  Velasquez Escobar, Beatriz Eugenia;  Velasco, Julian A.;  Lomascolo, Silvia;  Hoke, Kim;  Zeidemann, Vivian;  Almeida-Santos, Patricia;  Paola Ferraro, Daiana;  Araujo-Vieira, Katyuscia;  da Rocha, Sabine Borges;  Torres, Maria Fernanda;  Daniel Cadena, Carlos;  Collevatti, Rosane Garcia;  Vasconcellos, Mariana Mira;  Recart, Wilnelia;  Mitchell Aide, T.;  Bacon, Christine;  Jeckel, Adriana Moriguchi;  Diele-Viegas, Luisa Maria;  Calijorne Lourenco, Ana Carolina;  Santos, Danusy Lopes;  Rieder Cholak, Luiza;  Mendes, Roberta Graboski;  Silva, Fernanda Magalhaes;  Guedes, Thais;  Lopez-Perilla, Yeny R.;  Fusinatto, Luciana Ardenghi;  Terra, Juliana de Souza;  Rodriguez Brenes, Sofia;  Narvaez, Andrea E.;  Zina, Juliana;  Calderon-Espinosa, Martha L.;  Pardo-Diaz, Carolina;  Abadie, Michelle;  Maldonado-Chaparro, Adriana;  Cespedes Arias, Laura N.;  Montesinos, Rachel;  Fenker, Jessica;  Brunes, Tuliana Oliveira;  Ferreira Lantyer Silva, Amanda Santiago;  Vallejos, Johana Goyes;  Costa Rodrigues, Ana Paula V.;  Friol, Natalia Rizzo;  Herrera-Alvarez, Santiago;  de Souza, Eletra;  Araujo, Olivia G. S.;  Citeli, Nathalie Q. K.;  Ruggeri, Joice;  Fierro-Calderon, Eliana;  Acevedo-Charry, Orlando;  Barato, Paola;  Campos-Cerqueira, Marconi;  Mazzini, Flavia;  Beltran, Ivan;  Alejandra Meneses-Giorgi, Maria;  Jerez, Adriana;  Clavijo, Andrea P.;  Neira Jimenez, Carolina;  Dantas, Gisele P. M.;  Nascimento, Luciana Barreto;  Caballero, Susana J.;  Henao Sepulveda, A. Carolina;  Wolff, Marta;  Barnabe, Paula Cristina;  Quinones-Lebron, Shakira G.;  Bressan, Raissa Fries;  Gomez-Montoya, Nataly;  Gomez, Camila;  Colon-Pineiro, Zuania;  Esquivel Dobles, Carolina;  Bloch, Natasha;  Stynoski, Jennifer L.;  Arango, Daniel;  Marisol Gonzalez, Tania;  Luque Moreno, Francisco;  Taylor, Ryan;  Lawrence, J. P.;  Briscoe, Adriana Darielle Mejia;  Ortiz-Barrientos, Daniel;  Elena Salerno, Patricia;  Restrepo, Silvia;  Pasukonis, Andrius;  Damasceno, Roberta Pacheco;  Cecilia Dalton, Maria;  Proehl, Heike;  Valdez-Ward, Evelyn;  Andrea Rodriguez, Sabrina;  Marquez Garcia, Marcela;  Bianca Bonaparte, Eugenia;  Molina Escobar, Jorge Alberto;  Brown, Jason L.;  Yeager, Justin;  Kikuchi, David;  Ringler, Max;  Duran, Linda Hernandez;  Schulte, Lisa M.;  Vaira, Marcos;  Pereyra, Laura;  Astudillo Bravo, Diana;  Jose Salica, Maria;  Varga, Sandra;  Eguren, Antonieta;  Grattarola, Florencia;  Bernal, Moises A.;  Soledad Gaston, Maria;  Ortega Chinchilla, Jesus Eduardo;  Burdfield-Steel, Emily;  Valencia, Lina M.;  Ringler, Eva;  Rada, Marco;  Melendez-Ackerman, Elvia;  Botero, Carlos A.;  Estrada-Villegas, Sergio;  Orizaola, German;  Pinto, Brendan J.;  Gonzalez-Bellido, Paloma;  Hunter, Kimberly L.;  Rueda Solano, Luis Alberto;  Gordon, Swanne;  Guerra, Monica A.;  Jose Albo, Maria;  Vega-Frutis, Rocio;  Blundo, Cecilia;  Castaneda-Gomez, Laura;  Donnelly, Maureen A.;  Escobar, Betsabe D. Castro;  Isabel Moreno, Maria;  Crawford, Andrew J.;  Jiggins, Chris D.;  Roessler, Daniela C.;  Bravo Valencia, Laura;  Sarmiento, Carolina;  Munoz, Karen A.;  Galeano, Sandra P.;  del Rosario Castaneda, Maria;  Caro Cardenas, Cindy Jeanet;  Zalamea, Paul-Camilo;  Arias, Monica;  Zank, Caroline;  Suarez-Mayorga, Angela M.;  Colombo, Patrick;  Cuervo, Andres M.;  Coriolano, Iara Reinaldo;  de Melo, Lilian Sayuri Ouchi;  Buitrago Cardona, Alexandra;  Elias, Marianne;  Gonzalez, Mabel;  Maria Aldana, Ana;  Gubert, Carolina;  Luis Parra, Juan;  Contador, Tamara;  Coelho, Lorena;  Trillo, Mariana;  Bordin, Kauane;  Zulian, Viviane;  Moreno Arias, Rafael;  Loretto, Matthias-Claudio;  Alejandra Medina, Claudia;  Lyra, Mariana L.;  Pulido-Santacruz, Paola;  Rosser, Neil;  Waldron, Talia;  Moreno Duran, Carmen Helena;  Pizano, Camila;  Hoedl, Walter;  Fratani, Jessica;  Duport Bru, Ana Sofia;  Grosso, Jimena;  Vera Candioti, Florencia;  Adarve Rengifo, Isabel
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