Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

doi:10.1038/s41467-017-02504-1

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-017-02504-1
	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
	Shungin, Dmitry 1,2; Hawort, Simon 3,4; Divaris, Kimon 5,6; Agler, Cary S.7; Kamatani, Yoichiro 8; Lee, Myoung Keun 9; Grinde, Kelsey 10; Hindy, George 11; Alaraudanjoki, Viivi 12; Pesonen, Paula 13; Teumer, Alexander 14; Holtfreter, Birte 15; Sakaue, Saori 16; Hirata, Jun 16; Yu, Yau-Hua 17,18; Ridker, Paul M.17,19; Giulianini, Franco 17; Chasman, Daniel, I 17,19; Magnusson, Patrik K. E.20; Sudo, Takeaki 21; Okada, Yukinori 16; Voelker, Uwe 22; Kocher, Thomas 15; Anttonen, Vuokko 12,23,24; Laitala, Marja-Liisa 12; Orho-Melander, Marju 11; Sofer, Tamar 19,25; Shaffer, John R.9,26,27; Vieira, Alexandre 27; Marazita, Mary L.9,26,27; Kubo, Michiaki 8; Furuichi, Yasushi 28; North, Kari E.29; Offenbacher, Steve 30; Ingelsson, Erik 31,32,33; FrankS, Paul W.34,35,36; Timpson, Nicholas J.3; Johansson, Ingegerd 1
	2019-06-24
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	Sweden; USA; England; Japan; Finland; Germany
英文摘要	Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000472598400005
WOS关键词	LD SCORE REGRESSION ; ASSOCIATION METAANALYSIS ; MENDELIAN RANDOMIZATION ; GENETIC-BASIS ; HERITABILITY ; DISEASES ; GWAS ; POPULATION ; EXPRESSION ; INSIGHTS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203616
专题	资源环境科学
作者单位	1.Umea Univ, Dept Odontol, SE-90185 Umea, Sweden; 2.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 3.Univ Bristol Sch Med, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England; 4.Bristol Dent Sch, Bristol BS1 2LY, Avon, England; 5.Univ N Carolina, Sch Dent, Dept Pediat Dent, Chapel Hill, NC 27599 USA; 6.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA; 7.Univ N Carolina, Dept Oral & Craniofacial Hlth Sci, Chapel Hill, NC 27599 USA; 8.RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan; 9.Univ Pittsburgh, Ctr Craniofacial & Dent Genet, Sch Dent Med, Pittsburgh, PA 15219 USA; 10.Univ Washington, Dept Biostat, Seattle, WA 98195 USA; 11.Lund Univ, SE-22362 Lund, Sweden; 12.Univ Oulu, Res Unit Oral Hlth Sci, FI-90014 Oulu, Finland; 13.Univ Oulu, Fac Med, Infrastruct Populat Studies, FI-90014 Oulu, Finland; 14.Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany; 15.Univ Med Greifswald, Dept Restorat Dent Periodontol Endodontol & Preve, D-17475 Greifswald, Germany; 16.Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Osaka 5650871, Japan; 17.Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA; 18.Tufts Univ, Dept Periodontol, Sch Dent Med, Boston, MA 02111 USA; 19.Harvard Med Sch, Boston, MA 02115 USA; 20.Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden; 21.Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Periodontol, Tokyo 1138510, Japan; 22.Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany; 23.Oulu Univ Hosp, MRC, FI-90014 Oulu, Finland; 24.Univ Oulu, FI-90014 Oulu, Finland; 25.Brigham & Womens Hosp, Dept Sleep Med, Boston, MA 02130 USA; 26.Univ Pittburgh, Dept Human Genet, Pittsburgh, PA 15261 USA; 27.Univ Pittsburgh, Dept Oral Biol, Pittsburgh, PA 15213 USA; 28.Univ Hokkaido, Sch Dent, Dept Oral Rehabil, Hlth Sci,Div Periodontol & Endodontol, Tobetsu, Hokkaido 0610293, Japan; 29.Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27516 USA; 30.Univ N Carolina, Dept Periodontol, Chapel Hill, NC 27599 USA; 31.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA; 32.Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA; 33.Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA; 34.Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-21428 Malmo, Sweden; 35.Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden; 36.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Shungin, Dmitry,Hawort, Simon,Divaris, Kimon,et al. Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data[J]. NATURE COMMUNICATIONS,2019,10.
APA	Shungin, Dmitry.,Hawort, Simon.,Divaris, Kimon.,Agler, Cary S..,Kamatani, Yoichiro.,...&Johansson, Ingegerd.(2019).Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.NATURE COMMUNICATIONS,10.
MLA	Shungin, Dmitry,et al."Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data".NATURE COMMUNICATIONS 10(2019).