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Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Predominance of secondary organic aerosol to particle-bound reactive oxygen species activity in fine ambient aerosol 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 14703-14720
作者:  Zhou, Jun;  Elser, Miriam;  Huang, Ru-Jin;  Krapf, Manuel;  Frohlich, Roman;  Bhattu, Deepika;  Stefenelli, Giulia;  Zotter, Peter;  Bruns, Emily A.;  Pieber, Simone M.;  Ni, Haiyan;  Wang, Qiyuan;  Wang, Yichen;  Zhou, Yaqing;  Chen, Chunying;  Xiao, Mao;  Slowik, Jay G.;  Brown, Samuel;  Cassagnes, Laure-Estelle;  Daellenbach, Kaspar R.;  Nussbaumer, Thomas;  Geiser, Marianne;  Prevot, Andre S. H.;  El-Haddad, Imad;  Cao, Junji;  Baltensperger, Urs;  Dommen, Josef
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex 期刊论文
SCIENCE, 2019, 366 (6468) : 971-+
作者:  Lawrence, Rosalie E.;  Fromm, Simon A.;  Fu, Yangxue;  Yokom, Adam L.;  Kim, Do Jin;  Thelen, Ashley M.;  Young, Lindsey N.;  Lim, Chun-Yan;  Samelson, Avi J.;  Hurley, James H.;  Zoncu, Roberto
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
Australia-Asian monsoon in two versions of the UK Met Office Unified Model and their impacts on tropical-extratropical teleconnections 期刊论文
CLIMATE DYNAMICS, 2019, 53: 4717-4741
作者:  Jin, L.;  Zhang, H.;  Moise, A.;  Martin, G.;  Milton, S.;  Rodriguez, J.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Thermal unequilibrium of strained black CsPbI3 thin films 期刊论文
SCIENCE, 2019, 365 (6454) : 679-+
作者:  Steele, Julian A.;  Jin, Handong;  Dovgaliuk, Iurii;  Berger, Robert F.;  Braeckevelt, Tom;  Yuan, Haifeng;  Martin, Cristina;  Solano, Eduardo;  Lejaeghere, Kurt;  Rogge, Sven M. J.;  Notebaert, Charlotte;  Vandezande, Wouter;  Janssen, Kris P. F.;  Goderis, Bart;  Debroye, Elke;  Wang, Ya-Kun;  Dong, Yitong;  Ma, Dongxin;  Saidaminov, Makhsud;  Tan, Hairen;  Lu, Zhenghong;  Dyadkin, Vadim;  Chernyshov, Dmitry;  Van Speybroeck, Veronique;  Sargent, Edward H.;  Hofkens, Johan;  Roeffaers, Maarten B. J.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Gyrl-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yuan, Hua;  Zhang, Jinru;  Cai, Yujuan;  Wu, Sheng;  Yang, Kui;  Chan, H. C. Stephen;  Huang, Wei;  Jin, Wen-Bing;  Li, Yan;  Yin, Yue;  Igarashi, Yasuhiro;  Yuan, Shuguang;  Zhou, Jiahai;  Tang, Gong-Li
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
LNK suppresses interferon signaling in melanoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ding, Ling-Wen;  Sun, Qiao-Yang;  Edwards, Jarem J.;  Fernandez, Lucia Torres;  Ran, Xue-Bin;  Zhou, Si-Qin;  Scolyer, Richard A.;  Wilmott, James S.;  Thompson, John F.;  Ngan Doan;  Said, Jonathan W.;  Venkatachalam, Nachiyappan;  Xiao, Jin-Fen;  Loh, Xin-Yi;  Pein, Maren;  Xu, Liang;  Mullins, David W.;  Yang, Henry;  Lin, De-Chen;  Koeffler, H. Phillip
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Microwave photons emitted by fractionally charged quasiparticles (vol 10, 1708, 2019) 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Bisognin, R.;  Bartolomei, H.;  Kumar, M.;  Safi, I.;  Berroir, J. -M.;  Bocquillon, E.;  Placais, B.;  Cavanna, A.;  Gennser, U.;  Jin, Y.;  Feve, G.
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
A small-molecule fusion inhibitor of influenza virus is orally active in mice 期刊论文
SCIENCE, 2019, 363 (6431) : 1056-+
作者:  van Dongen, Maria J. P.;  Kadam, Rameshwar U.;  Juraszek, Jarek;  Lawson, Edward;  Brandenburg, Boerries;  Schmitz, Frederike;  Schepens, Wim B. G.;  Stoops, Bart;  van Diepen, Harry A.;  Jongeneelen, Mandy;  Tang, Chan;  Vermond, Jan;  Real, Alida van Eijgen-Obregoso;  Blokland, Sven;  Garg, Divita;  Yu, Wenli;  Goutier, Wouter;  Lanckacker, Ellen;  Klap, Jaco M.;  Peeters, Danielle C. G.;  Wu, Jin;  Buyck, Christophe;  Jonckers, Tim H. M.;  Roymans, Dirk;  Roevens, Peter;  Vogels, Ronald;  Koudstaal, Wouter;  Friesen, Robert H. E.;  Raboisson, Pierre;  Dhanak, Dashyant;  Goudsmit, Jaap;  Wilson, Ian A.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27