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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants 期刊论文
Science, 2021
作者:  Meng Yuan;  Deli Huang;  Chang-Chun D. Lee;  Nicholas C. Wu;  Abigail M. Jackson;  Xueyong Zhu;  Hejun Liu;  Linghang Peng;  Marit J. van Gils;  Rogier W. Sanders;  Dennis R. Burton;  S. Momsen Reincke;  Harald Prüss;  Jakob Kreye;  David Nemazee;  Andrew B. Ward;  Ian A. Wilson
收藏  |  浏览/下载:11/0  |  提交时间:2021/08/17
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape 期刊论文
Science, 2021
作者:  Paul-Albert Koenig;  Hrishikesh Das;  Hejun Liu;  Beate M. Kümmerer;  Florian N. Gohr;  Lea-Marie Jenster;  Lisa D. J. Schiffelers;  Yonas M. Tesfamariam;  Miki Uchima;  Jennifer D. Wuerth;  Karl Gatterdam;  Natalia Ruetalo;  Maria H. Christensen;  Caroline I. Fandrey;  Sabine Normann;  Jan M. P. Tödtmann;  Steffen Pritzl;  Leo Hanke;  Jannik Boos;  Meng Yuan;  Xueyong Zhu;  Jonathan L. Schmid-Burgk;  Hiroki Kato;  Michael Schindler;  Ian A. Wilson;  Matthias Geyer;  Kerstin U. Ludwig;  B. Martin Hällberg;  Nicholas C. Wu;  Florian I. Schmidt
收藏  |  浏览/下载:19/0  |  提交时间:2021/02/17
Structural basis of a shared antibody response to SARS-CoV-2 期刊论文
Science, 2020
作者:  Meng Yuan;  Hejun Liu;  Nicholas C. Wu;  Chang-Chun D. Lee;  Xueyong Zhu;  Fangzhu Zhao;  Deli Huang;  Wenli Yu;  Yuanzi Hua;  Henry Tien;  Thomas F. Rogers;  Elise Landais;  Devin Sok;  Joseph G. Jardine;  Dennis R. Burton;  Ian A. Wilson
收藏  |  浏览/下载:11/0  |  提交时间:2020/09/08
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model 期刊论文
Science, 2020
作者:  Thomas F. Rogers;  Fangzhu Zhao;  Deli Huang;  Nathan Beutler;  Alison Burns;  Wan-ting He;  Oliver Limbo;  Chloe Smith;  Ge Song;  Jordan Woehl;  Linlin Yang;  Robert K. Abbott;  Sean Callaghan;  Elijah Garcia;  Jonathan Hurtado;  Mara Parren;  Linghang Peng;  Sydney Ramirez;  James Ricketts;  Michael J. Ricciardi;  Stephen A. Rawlings;  Nicholas C. Wu;  Meng Yuan;  Davey M. Smith;  David Nemazee;  John R. Teijaro;  James E. Voss;  Ian A. Wilson;  Raiees Andrabi;  Bryan Briney;  Elise Landais;  Devin Sok;  Joseph G. Jardine;  Dennis R. Burton
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
New Guinea has the world鈥檚 richest island flora 期刊论文
Nature, 2020
作者:  Rodrigo Cá;  mara-Leret;  David G. Frodin;  Frits Adema;  Christiane Anderson;  Marc S. Appelhans;  George Argent;  Susana Arias Guerrero;  Peter Ashton;  William J. Baker;  Anders S. Barfod;  David Barrington;  Renata Borosova;  Gemma L. C. Bramley;  Marie Briggs;  Sven Buerki;  Daniel Cahen;  Martin W. Callmander;  Martin Cheek;  Cheng-Wei Chen;  Barry J. Conn;  Mark J. E. Coode;  Iain Darbyshire;  Sally Dawson;  John Dransfield;  Clare Drinkell;  Brigitta Duyfjes;  Atsushi Ebihara;  Zacky Ezedin;  Long-Fei Fu;  Osia Gideon;  Deden Girmansyah;  Rafaë;  l Govaerts;  Helen Fortune-Hopkins;  Gustavo Hassemer;  Alistair Hay;  Charlie D. Heatubun;  D. J. Nicholas Hind;  Peter Hoch;  Peter Homot;  Peter Hovenkamp;  Mark Hughes;  Matthew Jebb;  Laura Jennings;  Tiberius Jimbo;  Michael Kessler;  Ruth Kiew;  Sandra Knapp;  Penniel Lamei;  Marcus Lehnert;  Gwilym P. Lewis;  Hans Peter Linder;  Stuart Lindsay;  Yee Wen Low;  Eve Lucas;  Jeffrey P. Mancera;  Alexandre K. Monro;  Alison Moore;  David J. Middleton;  Hidetoshi Nagamasu;  Mark F. Newman;  Eimear Nic Lughadha;  Pablo H. A. Melo;  Daniel J. Ohlsen;  Caroline M. Pannell;  Barbara Parris;  Laura Pearce;  Darin S. Penneys;  Leon R. Perrie;  Peter Petoe;  Axel Dalberg Poulsen;  Ghillean T. Prance;  J. Peter Quakenbush;  Niels Raes;  Michele Rodda;  Zachary S. Rogers;  André;  Schuiteman;  Pedro Schwartsburd;  Robert W. Scotland;  Mark P. Simmons;  David A. Simpson;  Peter Stevens;  Michael Sundue;  Weston Testo;  Anna Trias-Blasi;  Ian Turner;  Timothy Utteridge;  Lesley Walsingham;  Bruce L. Webber;  Ran Wei;  George D. Weiblen;  Maximilian Weigend;  Peter Weston;  Willem de Wilde;  Peter Wilkie;  Christine M. Wilmot-Dear;  Hannah P. Wilson;  John R. I. Wood;  Li-Bing Zhang;  Peter C. van Welzen
收藏  |  浏览/下载:31/0  |  提交时间:2020/08/18
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses 期刊论文
Science, 2020
作者:  Nicholas C. Wu;  Andrew J. Thompson;  Juhye M. Lee;  Wen Su;  Britni M. Arlian;  Jia Xie;  Richard A. Lerner;  Hui-Ling Yen;  Jesse D. Bloom;  Ian A. Wilson
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/22
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
Science, 2020
作者:  Meng Yuan;  Nicholas C. Wu;  Xueyong Zhu;  Chang-Chun D. Lee;  Ray T. Y. So;  Huibin Lv;  Chris K. P. Mok;  Ian A. Wilson
收藏  |  浏览/下载:15/0  |  提交时间:2020/05/13
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses 期刊论文
SCIENCE, 2019, 366 (6470) : 1216-+
作者:  Steichen, Jon M.;  Lin, Ying-Cing;  Havenar-Daughton, Colin;  Pecetta, Simone;  Ozorowski, Gabriel;  Willis, Jordan R.;  Toy, Laura;  Sok, Devin;  Liguori, Alessia;  Kratochvil, Sven;  Torres, Jonathan L.;  Kalyuzhniy, Oleksandr;  Melzi, Eleonora;  Kulp, Daniel W.;  Raemisch, Sebastian;  Hu, Xiaozhen;  Bernard, Steffen M.;  Georgeson, Erik;  Phelps, Nicole;  Adachi, Yumiko;  Kubitz, Michael;  Landais, Elise;  Umotoy, Jeffrey;  Robinson, Amanda;  Briney, Bryan;  Wilson, Ian A.;  Burton, Dennis R.;  Ward, Andrew B.;  Crotty, Shane;  Batista, Facundo D.;  Schief, William R.
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17
Broadly protective human antibodies that target the active site of influenza virus neuraminidase 期刊论文
SCIENCE, 2019, 366 (6464) : 499-+
作者:  Stadlbauer, Daniel;  Zhu, Xueyong;  McMahon, Meagan;  Turner, Jackson S.;  Wohlbold, Teddy J.;  Schmitz, Aaron J.;  Strohmeier, Shirin;  Yu, Wenli;  Nachbagauer, Raffael;  Mudd, Philip A.;  Wilson, Ian A.;  Ellebedy, Ali H.;  Krammer, Florian
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27