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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome 期刊论文
SCIENCE, 2019, 366 (6467) : 843-+
作者:  Zhu, Ping Jun;  Khatiwada, Sanjeev;  Cui, Ya;  Reineke, Lucas C.;  Dooling, Sean W.;  Kim, Jean J.;  Li, Wei;  Walter, Peter;  Costa-Mattioli, Mauro
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling 期刊论文
SCIENCE, 2019, 365 (6448) : 47-+
作者:  Abdel-Nour, Mena;  Carneiro, Leticia A. M.;  Downey, Jeffrey;  Tsalikis, Jessica;  Outlioua, Ahmed;  Prescott, Dave;  Da Costa, Leandro Silva;  Hovingh, Elise S.;  Farahvash, Armin;  Gaudet, Ryan G.;  Molinaro, Raphael;  van Dalen, Rob;  Lau, Charles C. Y.;  Azimi, Farshad C.;  Escalante, Nichole K.;  Trotman-Grant, Aaron;  Lee, Jeffrey E.;  Gray-Owen, Scott D.;  Divangahi, Maziar;  Chen, Jane-Jane;  Philpott, Dana J.;  Arnoult, Damien;  Girardin, Stephen E.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
STRUCTURAL BIOLOGY Structural basis for eIF2B inhibition in integrated stress response 期刊论文
SCIENCE, 2019, 364 (6439) : 495-+
作者:  Kashiwagi, Kazuhiro;  Yokoyama, Takeshi;  Nishimoto, Madoka;  Takahashi, Mari;  Sakamoto, Ayako;  Yonemochi, Mayumi;  Shirouzu, Mikako;  Ito, Takuhiro
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
STRUCTURAL BIOLOGY eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response 期刊论文
SCIENCE, 2019, 364 (6439) : 491-+
作者:  Kenner, Lillian R.;  Anand, Aditya A.;  Nguyen, Henry C.;  Myasnikov, Alexander G.;  Klose, Carolin J.;  McGeever, Lea A.;  Tsai, Jordan C.;  Miller-Vedam, Lakshmi E.;  Walter, Peter;  Frost, Adam
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Quantifying the contribution of recessive coding variation to developmental disorders 期刊论文
SCIENCE, 2018, 362 (6419) : 1161-+
作者:  Martin, Hilary C.;  Jones, Wendy D.;  McIntyre, Rebecca;  Sanchez-Andrade, Gabriela;  Sanderson, Mark;  Stephenson, James D.;  Jones, Carla P.;  Handsaker, Juliet;  Gallone, Giuseppe;  Bruntraeger, Michaela;  McRae, Jeremy F.;  Prigmore, Elena;  Short, Patrick;  Niemi, Mari;  Kaplanis, Joanna;  Radford, Elizabeth J.;  Akavvi, Nadia;  Balasubramanian, Meena;  Dean, John;  Horton, Rachel;  Hulbert, Alice;  Johnson, Diana S.;  Johnson, Katie;  Kumar, Dhavendra;  Lynch, Sally Ann;  Mehta, Sarju G.;  Morton, Jenny;  Parker, Michael J.;  Splitt, Miranda;  Turnpenny, Peter D.;  Vasudevan, Pradeep C.;  Wright, Michael;  Bassett, Andrew;  Gerety, Sebastian S.;  Wright, Caroline F.;  FitzPatrick, David R.;  Firth, Helen, V;  Hurles, Matthew E.;  Barrett, Jeffrey C.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells 期刊论文
SCIENCE, 2018, 361 (6399) : 285-+
作者:  Grevet, Jeremy D.;  Lan, Xianjiang;  Hamagami, Nicole;  Edwards, Christopher R.;  Sankaranarayanan, Laavanya;  Ji, Xinjun;  Bhardwaj, Saurabh K.;  Face, Carolyne J.;  Posocco, David F.;  Abdulmalik, Osheiza;  Keller, Cheryl A.;  Giardine, Belinda;  Sidoli, Simone;  Garcia, Ben A.;  Chou, Stella T.;  Liebhaber, Stephen A.;  Hardison, Ross C.;  Shi, Junwei;  Blobel, Gerd A.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule 期刊论文
SCIENCE, 2018, 359 (6383) : 1483-+
作者:  Tsai, Jordan C.;  Miller-Vedam, Lakshmi E.;  Anand, Aditya A.;  Jaishankar, Priyadarshini;  Nguyen, Henry C.;  Renslo, Adam R.;  Frost, Adam;  Walter, Peter
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B 期刊论文
SCIENCE, 2018, 359 (6383) : 1533-1536
作者:  Zyryanova, Alisa F.;  Weis, Felix;  Faille, Alexandre;  Alard, Akeel Abo;  Crespillo-Casado, Ana;  Sekine, Yusuke;  Harding, Heather P.;  Allen, Felicity;  Parts, Leopold;  Fromont, Christophe;  Fischer, Peter M.;  Warren, Alan J.;  Ron, David
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27