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DOI | 10.1126/science.aaw2922 |
STRUCTURAL BIOLOGY eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response | |
Kenner, Lillian R.1; Anand, Aditya A.1,2; Nguyen, Henry C.1; Myasnikov, Alexander G.1,3; Klose, Carolin J.1,2; McGeever, Lea A.1,2; Tsai, Jordan C.1,2; Miller-Vedam, Lakshmi E.1; Walter, Peter1,2; Frost, Adam1,4 | |
2019-05-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:491-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France |
英文摘要 | The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine triphosphatase that becomes activated by eIF2B, a two-fold symmetric and heterodecameric complex that functions as eIF2's dedicated nucleotide exchange factor. Phosphorylation converts eIF2 from a substrate into an inhibitor of eIF2B. We report cryo-electron microscopy structures of eIF2 bound to eIF2B in the dephosphorylated state. The structures reveal that the eIF2B decamer is a static platform upon which one or two flexible eIF2 trimers bind and align with eIF2B's bipartite catalytic centers to catalyze nucleotide exchange. Phosphorylation refolds eIF2 alpha, allowing it to contact eIF2B at a different interface and, we surmise, thereby sequestering it into a nonproductive complex. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600035 |
WOS关键词 | INITIATION-FACTOR 2B ; CRYSTAL-STRUCTURE ; ALPHA-SUBUNIT ; FACTOR EIF2B ; TRANSLATION ; BINDING ; EIF2-ALPHA ; INHIBITION ; RNA ; PHOSPHORYLATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201346 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA; 2.Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA; 3.Univ Strasbourg, CNRS, IGBMC, Ctr Integrat Biol,Dept Integrated Struct Biol, F-67404 Illkirch Graffenstaden, France; 4.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA |
推荐引用方式 GB/T 7714 | Kenner, Lillian R.,Anand, Aditya A.,Nguyen, Henry C.,et al. STRUCTURAL BIOLOGY eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response[J]. SCIENCE,2019,364(6439):491-+. |
APA | Kenner, Lillian R..,Anand, Aditya A..,Nguyen, Henry C..,Myasnikov, Alexander G..,Klose, Carolin J..,...&Frost, Adam.(2019).STRUCTURAL BIOLOGY eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.SCIENCE,364(6439),491-+. |
MLA | Kenner, Lillian R.,et al."STRUCTURAL BIOLOGY eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response".SCIENCE 364.6439(2019):491-+. |
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